Nutrition, Metabolism, and Wound Healing in the Elderly

Author(s):  
Danny O. Jacobs ◽  
Tirso Mark Lara
Keyword(s):  
Author(s):  
Jia-Yu Wei ◽  
Shu-Ting Shi ◽  
Dan Sun ◽  
Guo-Zhong Lyu

Abstract Objective Nutritional assessment can early identify patients who are malnourished and at risk of malnutrition. To examine the effect of nutritional status on wound healing in elderly burn patients, we used the MNA-SF to measure the nutritional status of elderly patients. This study aimed to examine the role of MNA-SF in elderly burn patients through the correlation analysis of wound-healing indicators and MNA-SF score. Design Prospective observational and cross-sectional study. Methods This study used the MNA-SF to investigate the elderly burn patients at the department of burn. According to the score, the patients fell into three groups: good nutritional status (more than 12 points), malnutrition risk (8~11 points), and malnutrition (0~7 points). At the same time, we measured and compared the wound-healing indicators among the three groups of patients, and detected the correlation. Results The statistical analysis found gender had a slight influence on the score of nutritional status. While age was negatively correlated with the MNA-SF score and nutrition-related indicators. There was a low positive linear correlation between the wound healing percent area change or wound healing rate of patients and the score of the MNA-SF. Conclusion This study finds malnutrition is common among hospitalized elderly burn patients. The application of the MNA-SF in elderly burn patients is efficient and accurate to identify malnutrition early and prevent further obstruction of the normal wound healing, which can provide reference points for early nutrition intervention programs.


Author(s):  
Christopher G. Engeland ◽  
Praveen K. Gajendrareddy
Keyword(s):  

2010 ◽  
Vol 159 (1) ◽  
pp. 503-508 ◽  
Author(s):  
Jiong Jiong Guo ◽  
Huilin Yang ◽  
Haixin Qian ◽  
Lixin Huang ◽  
Zhongxing Guo ◽  
...  

Author(s):  
Krishna Priya Arjunan ◽  
Gary Friedman ◽  
Alisa Morss Clyne

Angiogenesis, the growth of new blood vessels from existing vessels, plays a key role in growth, and wound healing. Insufficient vascularization contributes to impaired wound healing in diabetic patients and the elderly. Tissue engineering is limited by the inability to adequately vascularize constructs to provide nutrients to the tissue core, thus limiting the size of engineered organs.


2017 ◽  
Vol 15 (3) ◽  
pp. 255-275 ◽  
Author(s):  
Evgenia Makrantonaki ◽  
Meinhard Wlaschek ◽  
Karin Scharffetter-Kochanek
Keyword(s):  

2020 ◽  
Vol 8 (4) ◽  
pp. 369-376
Author(s):  
O.V. Lihonenko ◽  
S.M. Zhdanov ◽  
O.V. Storozhenko ◽  
A.B. Zubaha ◽  
I.A. Shumejko

Wound healing in the elderly and senile is slower than in the young, one explanation for this is a decrease in estrogen levels and poor functioning of cells involved in various phases of the wound process.


1982 ◽  
Vol 36 (5) ◽  
pp. 1046-1059 ◽  
Author(s):  
H H Sandstead ◽  
L K Henriksen ◽  
J L Greger ◽  
A S Prasad ◽  
R A Good

1990 ◽  
Vol 80 (11) ◽  
pp. 577-582 ◽  
Author(s):  
C Muehlman ◽  
F Rahimi

The authors present a concise review of age-related changes that occur in the skin and its derivatives, as they pertain to the podiatric practitioner. A brief discussion of wound healing and several common skin disorders that affect the elderly is also included.


BMC Genomics ◽  
2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Pavel Abaffy ◽  
Silvie Tomankova ◽  
Ravindra Naraine ◽  
Mikael Kubista ◽  
Radek Sindelka

Abstract Background The study of the mechanisms controlling wound healing is an attractive area within the field of biology, with it having a potentially significant impact on the health sector given the current medical burden associated with healing in the elderly population. Healing is a complex process and includes many steps that are regulated by coding and noncoding RNAs, proteins and other molecules. Nitric oxide (NO) is one of these small molecule regulators and its function has already been associated with inflammation and angiogenesis during adult healing. Results Our results showed that NO is also an essential component during embryonic scarless healing and acts via a previously unknown mechanism. NO is mainly produced during the early phase of healing and it is crucial for the expression of genes associated with healing. However, we also observed a late phase of healing, which occurs for several hours after wound closure and takes place under the epidermis and includes tissue remodelling that is dependent on NO. We also found that the NO is associated with multiple cellular metabolic pathways, in particularly the glucose metabolism pathway. This is particular noteworthy as the use of NO donors have already been found to be beneficial for the treatment of chronic healing defects (including those associated with diabetes) and it is possible that its mechanism of action follows those observed during embryonic wound healing. Conclusions Our study describes a new role of NO during healing, which may potentially translate to improved therapeutic treatments, especially for individual suffering with problematic healing.


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