Effect of Ciliary Neurotrophic Factor on β-Amyloid Precursor Protein mRNA Expression

1995 ◽  
pp. 171-175
Author(s):  
Shinji Sudoh ◽  
Hideshi Kawakami ◽  
Yasuyo Mimori ◽  
Mituhiro Ohta ◽  
Shigenobu Nakamura
Keyword(s):  
Amyloid Precursor Protein ◽  
Mrna Expression ◽  
Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor ◽  
Precursor Protein ◽  
Β Amyloid

Restraint stress induces β-amyloid precursor protein mRNA expression in the rat basolateral amygdala

2005 ◽  
Vol 65 (1) ◽  
pp. 69-75 ◽  
Author(s):  
Maria Luiza Nunes Mamede Rosa ◽  
Francisco Silveira Guimarães ◽  
Rubia Maria Welfort de Oliveira ◽  
Cláudia Maria Padovan ◽  
Ronald Carl Alan Pearson ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Mrna Expression ◽  
Restraint Stress ◽  
Basolateral Amygdala ◽  
Precursor Protein ◽  
Β Amyloid

Activity-dependent increase in β-amyloid precursor protein mRNA expression in neurons

Neuroreport ◽  
2004 ◽  
Vol 15 (8) ◽  
pp. 1329-1333 ◽  
Author(s):  
Akiko Tabuchi ◽  
Asami Ishii ◽  
Mamoru Fukuchi ◽  
Sachiyo Kobayashi ◽  
Toshiharu Suzuki ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Mrna Expression ◽  
Precursor Protein ◽  
Β Amyloid ◽  
Activity Dependent

Alzheimer's disease: β-amyloid precursor protein mRNA expression in mononuclear blood cells

1991 ◽  
Vol 132 (1) ◽  
pp. 109-112 ◽  
Author(s):  
John S. Allen ◽  
Greer M. Murphy ◽  
Lawrence F. Eng ◽  
Karen E. Stultz ◽  
Helen D. Davies ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Precursor Protein ◽  
Mrna Expression ◽  
Blood Cells ◽  
Precursor Protein ◽  
Β Amyloid ◽  
Mononuclear Blood Cells

scholarly journals The effect of cannabinoids on APP, BACE1, and ApoE mRNA expression

SURG Journal ◽  
2014 ◽  
Vol 7 (1) ◽  
pp. 47-55
Author(s):  
Navjit Brar
Keyword(s):  
Amyloid Precursor Protein ◽  
Apolipoprotein E ◽  
Mrna Expression ◽  
Cell Line ◽  
Cb1 Receptor ◽  
Precursor Protein ◽  
Mrna Levels ◽  
Β Amyloid ◽  
Apoe Mrna ◽  
The Brain

Alzheimer's disease (AD) is an age-related neurodegenerative condition associated with cognitive decline. The pathological hallmark of this disease is the deposition of β-amyloid protein plaques (Aβ) in the brain, which evoke neuronal cell death and impair inter-neuronal communication. Past studies have suggested that cannabinoids reduce the levels of Aβ in the brain; however, little is known about the mechanisms involved in this process. In this study, the SH-SY5Y cell line was first examined for expression of amyloid precursor protein (APP), beta-site APP cleaving enzyme 1 (BACE1), and apolipoprotein E (ApoE), genes involved in Aβ production and clearance. All three genes were expressed and detected in the cell line. We then observed the effects of the endocannabinoid anandamide, a CB1 receptor agonist, on the mRNA expression of APP, BACE1, and ApoE in SH-SY5Y cells. After 48h exposure to anandamide, mRNA levels of APP and BACE1 significantly decreased, which could contribute to reduced Aβ levels. The mechanism of action by which anandamide reduces mRNA levels of APP and BACE1 should be further investigated. ApoE mRNA levels were not found to be significantly changed, suggesting that anandamide does not affect mRNA expression of this gene. The effects of cannabinoids on ApoE levels should be further studied as the effects may occur at a level different from mRNA expression and may even occur via a pathway unrelated to CB1 receptor activation. Keywords: Alzheimer’s disease; β-amyloid; anandamide; amyloid precursor protein; beta-site APP cleaving enzyme 1; apolipoprotein E

scholarly journals β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

Cell ◽  
1995 ◽  
Vol 81 (4) ◽  
pp. 525-531 ◽  
Author(s):  
Hui Zheng ◽  
Minghao Jiang ◽  
Myrna E. Trumbauer ◽  
Dalip J.S. Sirinathsinghji ◽  
Ruth Hopkins ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Reactive Gliosis ◽  
Β Amyloid ◽  
Deficient Mice
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