C-MYC: Oncogene and Tumour Suppressor Gene

Apoptosis ◽  
1994 ◽  
pp. 63-84 ◽  
Author(s):  
Gerard Evan ◽  
Trevor Littlewood ◽  
David Hancock ◽  
Martin Bennett ◽  
Elizabeth Harrington ◽  
...  
Keyword(s):  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Myc Oncogene

scholarly journals TP53 and C-MYC Co-Alterations – A Hallmark of Oral Cancer Progression / SIMULTANA ALTERACIJA TP53 I C-MYC GENA – OBELEŽJE PROGRESIJE ORALNIH KARCINOMA

2013 ◽  
Vol 32 (4) ◽  
pp. 380-388 ◽  
Author(s):  
Nasta Tanić ◽  
Jelena Milašin ◽  
Tatjana Dramićanin ◽  
Maja Bošković ◽  
Miroslav Vukadinović ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Progression ◽  
Squamous Cell ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Pcr Analysis ◽  
Squamous Cell Carci ◽  
Myc Oncogene ◽  
Specific Pcr

Summary Background: Head and neck squamous cell carcinoma, including oral cancer, is the sixth most common cancer worldwide. Despite advances in surgery and treatment, the 5-year survival rate has not improved significantly. There- fore, reliable molecular markers for oral cancer progression are badly needed. Methods: We conducted a copy number analysis to esti- mate amplification status of c-myc, cycD1 and EGFR onco- genes, mutational PCR-SSCP analysis to determine activa- tion of H-ras oncogene and inactivation of TP55 tumour suppressor gene and methylation specific PCR analysis to evaluate hypermethylation of p16 and MGMT genes. Results: c-myc oncogene was amplified in 56.7%, cycD1 in 20% and EGFR in 16.7% of Oral Squamous Cell Carci- noma (OSCC) cases while H-ras was activated in 33.3% of samples. Amplification of c-myc was significantly associat- ed with the tumour grade 2. Interestingly, EGFR and H-ras alterations were mutually exclusive. p16 and MGMT were inactivated by hypermethylation in 30% and 13.3% of cases. Co-alteration of cycD1 and p16 were not observed in any of the analyzed samples. TP53 was inactivated in 56.7% of samples and was significantly associated with progression of OSCC, grade 2 and stage 2. Moreover, TP55 and c-myc oncogene were simultaneously altered in grade 2 OSCC. Conclusions: The most promising marker of OSCC pro- gression remains the TP53 tumour suppressor, which is the most frequently mutated gene in oral cancers. Since there is synergism between TP55 and c-myc, it seems that co- alteration of these two genes could be also a good marker of OSCC progression from gradel to grade 2 tumours.

The tumour suppressor gene and the tobacco industry: research, debate, and conflict of interest

The Lancet ◽  
2005 ◽  
Vol 365 (9458) ◽  
pp. 531-540
Author(s):  
A BITTON ◽  
M NEUMAN ◽  
J BARNOYA ◽  
S GLANTZ
Keyword(s):  
Conflict Of Interest ◽  
Tobacco Industry ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Industry Research

tumour suppressor gene and the tobacco industry

The Lancet ◽  
2005 ◽  
Vol 365 (9464) ◽  
pp. 1026-1027
Author(s):  
A BITTON ◽  
M NEUMAN ◽  
J BARNOYA ◽  
S GLANTZ
Keyword(s):  
Tobacco Industry ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor

FOXL2 in adult‐type granulosa cell tumour of the ovary: oncogene or tumour suppressor gene?

2021 ◽  
Author(s):  
Jessica A. Pilsworth ◽  
Anne‐Laure Todeschini ◽  
Samantha J. Neilson ◽  
Dawn R. Cochrane ◽  
Daniel Lai ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Cell Tumour ◽  
Granulosa Cell Tumour ◽  
Adult Type

scholarly journals The tumour suppressor gene p53 modulates the severity of antigen-induced arthritis and the systemic immune response

2008 ◽  
Vol 152 (2) ◽  
pp. 345-353 ◽  
Author(s):  
M. Leech ◽  
J. R. Xue ◽  
A. Dacumos ◽  
P. Hall ◽  
L. Santos ◽  
...  
Keyword(s):  
Immune Response ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Systemic Immune Response

Mutation of the p53 tumour suppressor gene and overexpression of its protein in 62 Japanese non-Hodgkin’s lymphomas

2007 ◽  
Vol 7 (2) ◽  
pp. 39-46 ◽  
Author(s):  
H. Kamata ◽  
S. Mitani ◽  
M. Fujiwara ◽  
N. Aoki ◽  
S. Okada ◽  
...  
Keyword(s):  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
P53 Tumour Suppressor Gene ◽  
Hodgkin's Lymphomas

scholarly journals PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1

FEBS Letters ◽  
2011 ◽  
Vol 585 (7) ◽  
pp. 1089-1096 ◽  
Author(s):  
Daniel E. Foxler ◽  
Victoria James ◽  
Samuel J. Shelton ◽  
Thomas Q. de A. Vallim ◽  
Peter E. Shaw ◽  
...  
Keyword(s):  
Transcriptional Activator ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor
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