Architecture and Hemodynamics of Microvascular Networks

1995 ◽  
pp. 159-176 ◽  
Author(s):  
T. W. Secomb ◽  
A. R. Pries ◽  
P. Gaehtgens
Keyword(s):  
Microvascular Networks

scholarly journals A modular microfluidic system based on a multilayered configuration to generate large-scale perfusable microvascular networks

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Tao Yue ◽  
Da Zhao ◽  
Duc T. T. Phan ◽  
Xiaolin Wang ◽  
Joshua Jonghyun Park ◽  
...  
Keyword(s):  
Large Scale ◽  
Circulatory System ◽  
Vertical Direction ◽  
Microfluidic System ◽  
Vital Role ◽  
Microvascular Networks ◽  
Biological Studies ◽  
Wide Range ◽  
High Flexibility

AbstractThe vascular network of the circulatory system plays a vital role in maintaining homeostasis in the human body. In this paper, a novel modular microfluidic system with a vertical two-layered configuration is developed to generate large-scale perfused microvascular networks in vitro. The two-layer polydimethylsiloxane (PDMS) configuration allows the tissue chambers and medium channels not only to be designed and fabricated independently but also to be aligned and bonded accordingly. This method can produce a modular microfluidic system that has high flexibility and scalability to design an integrated platform with multiple perfused vascularized tissues with high densities. The medium channel was designed with a rhombic shape and fabricated to be semiclosed to form a capillary burst valve in the vertical direction, serving as the interface between the medium channels and tissue chambers. Angiogenesis and anastomosis at the vertical interface were successfully achieved by using different combinations of tissue chambers and medium channels. Various large-scale microvascular networks were generated and quantified in terms of vessel length and density. Minimal leakage of the perfused 70-kDa FITC-dextran confirmed the lumenization of the microvascular networks and the formation of tight vertical interconnections between the microvascular networks and medium channels in different structural layers. This platform enables the culturing of interconnected, large-scale perfused vascularized tissue networks with high density and scalability for a wide range of multiorgan-on-a-chip applications, including basic biological studies and drug screening.

scholarly journals Relationships Between Lymphangiogenesis and Angiogenesis During Inflammation in Rat Mesentery Microvascular Networks

2012 ◽  
Vol 10 (4) ◽  
pp. 198-207 ◽  
Author(s):  
Richard S. Sweat ◽  
Peter C. Stapor ◽  
Walter L. Murfee
Keyword(s):  
Microvascular Networks ◽  
Rat Mesentery

Fluid and protein exchange in microvascular networks: Importance of modelling heterogeneity in geometrical and biophysical properties

2021 ◽  
Author(s):  
Giovanna Guidoboni ◽  
Nicholas M. Marazzi ◽  
Joshua Fraser ◽  
Riccardo Sacco ◽  
Kannappan Palaniappan ◽  
...  
Keyword(s):  
Biophysical Properties ◽  
Microvascular Networks ◽  
Protein Exchange

Engineered 3D Microvascular Networks for the Study of Ultrasound-Microbubble-Mediated Drug Delivery

Langmuir ◽  
2018 ◽  
Vol 35 (31) ◽  
pp. 10128-10138 ◽  
Author(s):  
Eric K. Juang ◽  
Ine De Cock ◽  
Christina Keravnou ◽  
Madison K. Gallagher ◽  
Sara B. Keller ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Microvascular Networks

scholarly journals Microvascular networks with uniform flow

2019 ◽  
Vol 462 ◽  
pp. 48-64 ◽  
Author(s):  
Shyr-Shea Chang ◽  
Marcus Roper
Keyword(s):  
Uniform Flow ◽  
Microvascular Networks

A two-fluid model for hematocrit distribution in microvascular networks

1989 ◽  
Vol 16 (3) ◽  
pp. 319-325 ◽  
Author(s):  
J. E. I. Hokkanen
Keyword(s):  
Fluid Model ◽  
Microvascular Networks ◽  
Two Fluid Model ◽  
Two Fluid
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