Receptors for Erythropoietin Distribution, Structure, and Role in Receptor-Mediated Endocytosis in Erythroid Cells

1990 ◽  
pp. 365-402 ◽  
Author(s):  
Stephen T. Sawyer
Keyword(s):  
Erythroid Cells ◽  
Receptor Mediated Endocytosis ◽  
Distribution Structure ◽  
In Erythroid Cells

scholarly journals Developmental Expression of Mouse Erythrocyte Protein 4.2 mRNA: Evidence for Specific Expression in Erythroid Cells

Blood ◽  
1998 ◽  
Vol 91 (2) ◽  
pp. 695-705 ◽  
Author(s):  
Lingyun Zhu ◽  
Samir B. Kahwash ◽  
Long-Sheng Chang
Keyword(s):  
Mrna Expression ◽  
Fetal Liver ◽  
Late Gestation ◽  
Developmental Expression ◽  
Erythroid Cells ◽  
Mouse Development ◽  
Specific Expression ◽  
Protein 4.2 ◽  
Specific Regulation ◽  
In Erythroid Cells

Abstract Erythrocyte protein 4.2 (P4.2) is an important component of the erythrocyte membrane skeletal network with an undefined biologic function. Presently, very little is known about the expression of the P4.2 gene during mouse embryonic development and in adult animals. By using the Northern blot and in situ hybridization techniques, we have examined the spatial and temporal expression of the P4.2 gene during mouse development. We show that expression of the mouse P4.2 gene is temporally regulated during embryogenesis and that the P4.2 mRNA expression pattern coincides with the timing of erythropoietic activity in hematopoietic organs. P4.2 transcripts are first detected in embryos on day 7.5 of gestation and are localized exclusively in primitive erythroid cells of yolk sac origin. These erythroid cells remain to be the only source for P4.2 expression until the switch of the hematopoietic producing site to fetal liver. In mid- and late-gestation periods, P4.2 mRNA expression is restricted to the erythroid cells in fetal liver and to circulating erythrocytes. Around and after birth, the site for P4.2 expression is switched from liver to spleen and bone marrow, and P4.2 transcripts are only detected in cells of the erythroid lineage. These results provide the evidence for specific P4.2 expression in erythroid cells. In addition, the timing and pattern of expression of the P4.2 gene suggest the specific regulation of the P4.2 gene.

scholarly journals Palmitoylation of MPP1 (membrane-palmitoylated protein 1)/p55 is crucial for lateral membrane organization in erythroid cells.

2018 ◽  
Vol 293 (8) ◽  
pp. 2786-2786
Author(s):  
Agnieszka Łach ◽  
Michal Grzybek ◽  
Elżbieta Heger ◽  
Justyna Korycka ◽  
Marcin Wolny ◽  
...  
Keyword(s):  
Erythroid Cells ◽  
Membrane Organization ◽  
Lateral Membrane ◽  
In Erythroid Cells

trans-Activation of a globin promoter in nonerythroid cells

1991 ◽  
Vol 11 (2) ◽  
pp. 843-853
Author(s):  
T Evans ◽  
G Felsenfeld
Keyword(s):  
Dna Binding ◽  
Binding Sites ◽  
Gene Activation ◽  
Specific Factor ◽  
Erythroid Cells ◽  
Specific Manner ◽  
Alpha Globin ◽  
A Cell ◽  
Globin Promoter ◽  
In Erythroid Cells

We show that expression in fibroblasts of a single cDNA, encoding the erythroid DNA-binding protein Eryf1 (GF-1, NF-E1), very efficiently activates transcription of a chicken alpha-globin promoter, trans-Activation in these cells occurred when Eryf1 bound to a single site within a minimal globin promoter. In contrast, efficient activation in erythroid cells required multiple Eryf1 binding sites. Our results indicate that mechanisms exist that are capable of modulating the trans-acting capabilities of Eryf1 in a cell-specific manner, without affecting DNA binding. The response of the minimal globin promoter to Eryf1 in fibroblasts was at least as great as for optimal constructions in erythroid cells. Therefore, the assay provides a very simple and sensitive system with which to study gene activation by a tissue-specific factor.

Control of Iron Delivery to Haemoglobin in Erythroid Cells

2008 ◽  
pp. 167-200 ◽  
Author(s):  
Přemysl Poňka ◽  
Jan Neuwirt ◽  
Jitka Borovä ◽  
Ota Fuchs
Keyword(s):  
Erythroid Cells ◽  
Iron Delivery ◽  
In Erythroid Cells
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