Branched Chain Amino Acids in Heart Failure

2014 ◽  
pp. 81-88 ◽  
Author(s):  
Haipeng Sun ◽  
Yibin Wang
Keyword(s):  
Heart Failure ◽  
Amino Acids ◽  
Branched Chain Amino Acids ◽  
Branched Chain

scholarly journals Impact of Melatonin and Branched-Chain Amino Acids Cosupplementation on Quality of Life, Fatigue, and Nutritional Status in Cachectic Heart Failure Patients: A Randomized Controlled Trial

2019 ◽  
pp. 155982761987404 ◽  
Author(s):  
Hamed Jafari-Vayghan ◽  
Jalal Moludi ◽  
Sevda Saleh-Ghadimi ◽  
Elgar Enamzadeh ◽  
Mir Hossein Seyed-Mohammadzad ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Amino Acids ◽  
Placebo Group ◽  
Nutritional Status ◽  
Branched Chain Amino Acids ◽  
Significant Difference ◽  
Branched Chain ◽  
The Impact

Background: Cardiac cachexia (CC) adversely affects the lifestyle of heart failure (HF) patients. The current study examined the impact of melatonin cosupplementation and branched-chain amino acids (BCAAs) on quality of life (QoL), fatigue, and nutritional status in cachectic HF patients. Methods: In this trial, 84 CC patients were randomized to melatonin, BCAAs, or coadministration (both) as intervention groups and a control group over 8 weeks. At baseline and postintervention, QoL, fatigue, and nutritional status were assessed. Results: After intervention, improvement in the overall and physical dimensions of QoL and appetite score were found to be statistically significant in the BCAAs (P < .001) and the melatonin+BCAAs (P < .001) groups compared with the placebo group. The emotional dimension score was significantly lower in the BCAAs group compared with the placebo group (P = .001). There was a statistically significant improvement in fatigue severity in all 3 intervention groups compared with the placebo group. The nutrition risk index (NRI) score increased significantly only in the melatonin group (P = .015), and there was no significant difference between the other groups (P = .804). Conclusions: Cosupplementation with BCAAs and melatonin improved QoL, fatigue status, and appetite in cachectic HF patients but did not affect NRI.

Abstract 86: Catabolic Remodeling of Branched Chain Amino Acids in Heart Failure

2012 ◽  
Vol 111 (suppl_1) ◽  
Author(s):  
Haipeng Sun ◽  
Meiyi Zhou ◽  
Chen Gao ◽  
Kristine Olson ◽  
Ji-Youn Youn ◽  
...  
Keyword(s):  
Heart Failure ◽  
Amino Acids ◽  
Regulatory Protein ◽  
Pressure Overload ◽  
Branched Chain Amino Acids ◽  
Atp Production ◽  
Genetic Ablation ◽  
Catabolic Genes ◽  
Metabolic Remodeling ◽  
Branched Chain

Metabolic remodeling is an integral part of heart failure. Although glucose and fatty acids metabolism have been extensively studied, little is known about the role of amino acids homeostasis in heart physiology and pathology. Branched chain amino acids (BCAAs), including leucine, isoleucine, and valine, are essential amino acids for both protein synthesis and cellular signaling. Elevated levels of BCAAs have been linked with heart failure. However, the underlying regulatory mechanism and functional significance of abnormal BCAA catabolism in heart failure have not been established. We found that genes involved in BCAA catabolism, including a key regulatory protein PP2Cm, are significantly down-regulated at mRNA as well as protein level in pressure-overload induced failing heart in mice. Furthermore, the concentrations of BCAA catabolic products branched-chain keto acids (BCKAs) are also elevated in heart tissues of post TAC mice. Interestingly, the down-regulation of BCAA catabolic genes mimics a similar expression pattern observed in fetal heart, suggesting that decreased BCAA catabolic activity is part of the metabolic remodeling in pathologically stressed heart from an adult to a fetal-like state. Genetic ablation of PP2Cm in mouse leads to defect in BCAA catabolism and accumulation of BCAAs and BCKAs in cardiac tissue and serum. PP2Cm deficient mice had lower cardiac contractility and higher susceptibility to develop heart failure under pressure overload. In addition, BCKAs treatment to isolated mitochondria resulted in lower oxygen consumption rate and ATP production. PP2Cm deficiency as well as BCKAs treatment induced oxidative stress in cardiomyocyte and antioxidant treatment ameliorated the development of heart failure in PP2Cm deficient animals. Together, these data indicated that BCAA catabolic remodeling is likely an integrated component of metabolic remodeling during heart failure. More importantly, mis-regulation of BCAA catabolism in heart promoted heart failure progression, involving direct impact on mitochondrial function and redox homeostasis in cardiomyocytes.

Circulating branched‐chain amino acids and incident heart failure in type 2 diabetes: The Hong Kong Diabetes Register

2020 ◽  
Vol 36 (3) ◽  
Author(s):  
Lee‐Ling Lim ◽  
Eric S.H. Lau ◽  
Erik Fung ◽  
Heung‐Man Lee ◽  
Ronald C.W. Ma ◽  
...  
Keyword(s):  
Heart Failure ◽  
Type 2 Diabetes ◽  
Amino Acids ◽  
Hong Kong ◽  
Branched Chain Amino Acids ◽  
Incident Heart Failure ◽  
Branched Chain ◽  
Diabetes Register

Significance of Branched-Chain Amino Acids in Lean Patients With Heart Failure

2016 ◽  
Vol 22 (9) ◽  
pp. S218 ◽  
Author(s):  
Takayuki Namba ◽  
Toyokazu Kimura ◽  
Shunpei Horii ◽  
Risako Yasuda ◽  
Takumi Toya ◽  
...  
Keyword(s):  
Heart Failure ◽  
Amino Acids ◽  
Branched Chain Amino Acids ◽  
Patients With Heart Failure ◽  
Branched Chain

The Branched-Chain Amino Acids Level at Discharge is a Useful Prognostic Biomarker in Patients with Acute Heart Failure

2015 ◽  
Vol 21 (10) ◽  
pp. S173
Author(s):  
Hiroaki Hiraiwa ◽  
Takahiro Okumura ◽  
Toru Kondo ◽  
Soichiro Aoki ◽  
Rinya Kato ◽  
...  
Keyword(s):  
Heart Failure ◽  
Amino Acids ◽  
Acute Heart Failure ◽  
Prognostic Biomarker ◽  
Branched Chain Amino Acids ◽  
Branched Chain

scholarly journals Branched Chain Amino Acids

2019 ◽  
Vol 81 (1) ◽  
pp. 139-164 ◽  
Author(s):  
Michael Neinast ◽  
Danielle Murashige ◽  
Zoltan Arany
Keyword(s):  
Heart Failure ◽  
Amino Acids ◽  
Inborn Errors Of Metabolism ◽  
Deep Understanding ◽  
Building Blocks ◽  
Life Forms ◽  
Branched Chain Amino Acids ◽  
Foreseeable Future ◽  
Inborn Errors ◽  
Branched Chain

Branched chain amino acids (BCAAs) are building blocks for all life-forms. We review here the fundamentals of BCAA metabolism in mammalian physiology. Decades of studies have elicited a deep understanding of biochemical reactions involved in BCAA catabolism. In addition, BCAAs and various catabolic products act as signaling molecules, activating programs ranging from protein synthesis to insulin secretion. How these processes are integrated at an organismal level is less clear. Inborn errors of metabolism highlight the importance of organismal regulation of BCAA physiology. More recently, subtle alterations of BCAA metabolism have been suggested to contribute to numerous prevalent diseases, including diabetes, cancer, and heart failure. Understanding the mechanisms underlying altered BCAA metabolism and how they contribute to disease pathophysiology will keep researchers busy for the foreseeable future.

High Serum Branched-Chain Amino Acids Level Independently Predicts Incident Heart Failure—The Hong Kong Diabetes Register

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 455-P
Author(s):  
LEE-LING LIM ◽  
ERIC S.H. LAU ◽  
ANDREA LUK ◽  
ELAINE CHOW ◽  
HEUNG MAN LEE ◽  
...  
Keyword(s):  
Heart Failure ◽  
Amino Acids ◽  
Hong Kong ◽  
Branched Chain Amino Acids ◽  
High Serum ◽  
Incident Heart Failure ◽  
Branched Chain ◽  
Diabetes Register

scholarly journals Catabolism of Branched-Chain Amino Acids in Heart Failure: Insights from Genetic Models

2011 ◽  
Vol 32 (3) ◽  
pp. 305-310 ◽  
Author(s):  
Haipeng Sun ◽  
Gang Lu ◽  
Shuxun Ren ◽  
Jaunian Chen ◽  
Yibin Wang
Keyword(s):  
Heart Failure ◽  
Amino Acids ◽  
Branched Chain Amino Acids ◽  
Genetic Models ◽  
Branched Chain
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