Plasma Antioxidants and Glutamine Supplementation in HIV

Glutamine depletion is demonstrated to be an independent predictor of hospital mortality in ICU (intensive care unit) patients. Today glutamine supplementation is recommended to ICU patients on parenteral nutrition. In addition to glutamine, glutathione may be a limiting factor in ICU patients with MOF (multiple organ failure). To study the prevalence of glutamine and glutathione depletion an observational study was performed. The results were analysed in relation to mortality and the conventional predictors of mortality outcome, APACHE II (Acute Physiology and Chronic Health Evaluation II) and SOFA (Sequential Organ Failure Assessment). Consecutive patients admitted to the ICU at Karolinska University Hospital Huddinge were studied. Patient admission scoring of APACHE II and SOFA were registered as well as mortality up to 6 months. Plasma glutamine concentration and whole blood glutathione status at admittance were analysed. The admission plasma glutamine concentrations were totally independent of the conventional risk scoring at admittance, and a subnormal concentration was an independent predictor of mortality. In addition, glutathione redox status was also an independent mortality predictor, but here a normal ratio was the risk factor. In both cases the mortality risk was mainly confined to the post-ICU period. A low plasma concentration of glutamine at ICU admission is an independent risk factor for post-ICU mortality. The possible benefit of extending glutamine supplementation post-ICU should be evaluated prospectively.

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Glutamine Supplementation of Enteral Nutrition: Impact on Whole Body Protein Kinetics and Glucose Metabolism in Critically Ill Patients

Journal of Parenteral and Enteral Nutrition ◽

10.1177/0148607195019006470 ◽

1995 ◽

Vol 19 (6) ◽

pp. 470-476 ◽

Cited By ~ 35

Author(s):

Calvin L. Long ◽

Karl M. Nelson ◽

Douglas B. Dirienzo ◽

Jeffery K. Weis ◽

Richard D. Stahl ◽

...

Keyword(s):

Glucose Metabolism ◽

Enteral Nutrition ◽

Critically Ill ◽

Critically Ill Patients ◽

Whole Body ◽

Glutamine Supplementation ◽

Protein Kinetics ◽

Body Protein

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Enteral glutamine supplementation in surgical patients with head and neck malignancy: A randomized controlled trial

Head & Neck ◽

10.1002/hed.23839 ◽

2015 ◽

Vol 37 (12) ◽

pp. 1799-1807 ◽

Cited By ~ 6

Author(s):

Mawaddah Azman ◽

Mohd Razif Mohd Yunus ◽

Suhaina Sulaiman ◽

Syed Nabil Syed Omar

Keyword(s):

Randomized Controlled Trial ◽

Head And Neck ◽

Controlled Trial ◽

Surgical Patients ◽

Glutamine Supplementation ◽

Head And Neck Malignancy ◽

Randomized Controlled ◽

Neck Malignancy

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