Overview of Cell Synchronization

2016 ◽  
pp. 3-27 ◽  
Author(s):  
Gaspar Banfalvi
Keyword(s):  
Cell Synchronization

scholarly journals JunB Breakdown in Mid-/Late G2 Is Required for Down-Regulation of Cyclin A2 Levels and Proper Mitosis

2008 ◽  
Vol 28 (12) ◽  
pp. 4173-4187 ◽  
Author(s):  
Rosa Farràs ◽  
Véronique Baldin ◽  
Sandra Gallach ◽  
Claire Acquaviva ◽  
Guillaume Bossis ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Suppressor ◽  
Genetic Instability ◽  
S Phase ◽  
Subsequent Reduction ◽  
Suppressor Activity ◽  
Cell Synchronization ◽  
Tumor Suppressor Activity ◽  
A Cell ◽  
Cyclin A2

ABSTRACT JunB, a member of the AP-1 family of dimeric transcription factors, is best known as a cell proliferation inhibitor, a senescence inducer, and a tumor suppressor, although it also has been attributed a cell division-promoting activity. Its effects on the cell cycle have been studied mostly in G1 and S phases, whereas its role in G2 and M phases still is elusive. Using cell synchronization experiments, we show that JunB levels, which are high in S phase, drop during mid- to late G2 phase due to accelerated phosphorylation-dependent degradation by the proteasome. The forced expression of an ectopic JunB protein in late G2 phase indicates that JunB decay is necessary for the subsequent reduction of cyclin A2 levels in prometaphase, the latter event being essential for proper mitosis. Consistently, abnormal JunB expression in late G2 phase entails a variety of mitotic defects. As these aberrations may cause genetic instability, our findings contrast with the acknowledged tumor suppressor activity of JunB and reveal a mechanism by which the deregulation of JunB might contribute to tumorigenesis.

Decay of cell synchronization: Solutions of the cell-growth equation

1966 ◽  
Vol 28 (3) ◽  
pp. 391-409 ◽  
Author(s):  
Henry R. Hirsch ◽  
Joseph Engelberg
Keyword(s):  
Cell Growth ◽  
Growth Equation ◽  
Cell Synchronization

[20] Cell synchronization

1979 ◽  
pp. 248-262 ◽  
Author(s):  
Tsukasa Ashihara ◽  
Renato Baserga
Keyword(s):  
Cell Synchronization

Studies of hydroxyurea administered by continuous infusion. Toxicity, pharmacokinetics, and cell synchronization

Cancer ◽  
1980 ◽  
Vol 46 (3) ◽  
pp. 455-462 ◽  
Author(s):  
Robert J. Belt ◽  
Charles D. Haas ◽  
James Kennedy ◽  
Sarah Taylor
Keyword(s):  
Continuous Infusion ◽  
Cell Synchronization

Increase in etoposide-induced topoisomerase II-mediated DNA breaks after cell synchronization induced by low doses of methotrexate

1988 ◽  
Vol 37 (9) ◽  
pp. 1883-1884 ◽  
Author(s):  
Aurelio Lorico ◽  
Germana Rappa ◽  
Mauro Boiocchi ◽  
Fabio Anzanello ◽  
Maurizio D'Incalci
Keyword(s):  
Topoisomerase Ii ◽  
Low Doses ◽  
Dna Breaks ◽  
Cell Synchronization

Optimal scheduling for cell synchronization by cycle-phase-specific blockers

1983 ◽  
Vol 66 (2) ◽  
pp. 167-185 ◽  
Author(s):  
B.F. Dibrov ◽  
A.M. Zhabotinsky ◽  
Yu.A. Neyfakh ◽  
M.P. Orlova ◽  
L.I. Churikova
Keyword(s):  
Optimal Scheduling ◽  
Cycle Phase ◽  
Cell Synchronization

Influence of drugs on macromolecular synthesis during cell synchronization

1982 ◽  
Vol 17 (5) ◽  
pp. 343-357 ◽  
Author(s):  
J.L. Chiger ◽  
M.M. Widelitz ◽  
H. Kaji
Keyword(s):  
Macromolecular Synthesis ◽  
Cell Synchronization
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