Microglia Analysis in Retinal Degeneration Mouse Models

2018 ◽  
pp. 159-166 ◽  
Author(s):  
Katharina Dannhausen ◽  
Khalid Rashid ◽  
Thomas Langmann
Keyword(s):  
Retinal Degeneration ◽  
Mouse Models

scholarly journals Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss

Cells ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 931 ◽  
Author(s):  
Gayle B. Collin ◽  
Navdeep Gogna ◽  
Bo Chang ◽  
Nattaya Damkham ◽  
Jai Pinkney ◽  
...  
Keyword(s):  
Retinal Degeneration ◽  
Mouse Models ◽  
Laboratory Mouse ◽  
Gene List ◽  
Cell Loss ◽  
Mouse Genome Informatics ◽  
Future Research ◽  
Damage Repair ◽  
Wide Range ◽  
Inherited Retinal Degeneration

Inherited retinal degeneration (RD) leads to the impairment or loss of vision in millions of individuals worldwide, most frequently due to the loss of photoreceptor (PR) cells. Animal models, particularly the laboratory mouse, have been used to understand the pathogenic mechanisms that underlie PR cell loss and to explore therapies that may prevent, delay, or reverse RD. Here, we reviewed entries in the Mouse Genome Informatics and PubMed databases to compile a comprehensive list of monogenic mouse models in which PR cell loss is demonstrated. The progression of PR cell loss with postnatal age was documented in mutant alleles of genes grouped by biological function. As anticipated, a wide range in the onset and rate of cell loss was observed among the reported models. The analysis underscored relationships between RD genes and ciliary function, transcription-coupled DNA damage repair, and cellular chloride homeostasis. Comparing the mouse gene list to human RD genes identified in the RetNet database revealed that mouse models are available for 40% of the known human diseases, suggesting opportunities for future research. This work may provide insight into the molecular players and pathways through which PR degenerative disease occurs and may be useful for planning translational studies.

scholarly journals Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration

2013 ◽  
Vol 110 (13) ◽  
pp. 5181-5186 ◽  
Author(s):  
P. Barabas ◽  
A. Liu ◽  
W. Xing ◽  
C.-K. Chen ◽  
Z. Tong ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Retinal Degeneration ◽  
Mouse Models ◽  
Type 3 ◽  
Long Chain

scholarly journals Branched chain amino acids attenuate major pathologies in mouse models of retinal degeneration and glaucoma

Heliyon ◽  
2018 ◽  
Vol 4 (2) ◽  
pp. e00544 ◽  
Author(s):  
Tomoko Hasegawa ◽  
Hanako Ohashi Ikeda ◽  
Sachiko Iwai ◽  
Yuki Muraoka ◽  
Tatsuaki Tsuruyama ◽  
...  
Keyword(s):  
Amino Acids ◽  
Retinal Degeneration ◽  
Mouse Models ◽  
Branched Chain Amino Acids ◽  
Branched Chain

scholarly journals In vivo phenotypic and molecular characterization of retinal degeneration in mouse models of three ciliopathies

2019 ◽  
Vol 186 ◽  
pp. 107721 ◽  
Author(s):  
Agnès Brun ◽  
Xiangxiang Yu ◽  
Cathy Obringer ◽  
Daniel Ajoy ◽  
Elodie Haser ◽  
...  
Keyword(s):  
Retinal Degeneration ◽  
Molecular Characterization ◽  
Mouse Models

scholarly journals Primary amines protect against retinal degeneration in mouse models of retinopathies

2011 ◽  
Vol 8 (2) ◽  
pp. 170-178 ◽  
Author(s):  
Akiko Maeda ◽  
Marcin Golczak ◽  
Yu Chen ◽  
Kiichiro Okano ◽  
Hideo Kohno ◽  
...  
Keyword(s):  
Retinal Degeneration ◽  
Mouse Models ◽  
Primary Amines

scholarly journals Suppressing thyroid hormone signaling preserves cone photoreceptors in mouse models of retinal degeneration

2014 ◽  
Vol 111 (9) ◽  
pp. 3602-3607 ◽  
Author(s):  
Hongwei Ma ◽  
Arjun Thapa ◽  
Lynsie Morris ◽  
T. Michael Redmond ◽  
Wolfgang Baehr ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Retinal Degeneration ◽  
Mouse Models ◽  
Hormone Signaling ◽  
Cone Photoreceptors

scholarly journals Differential effects of N-acetylcysteine on retinal degeneration in two mouse models of normal tension glaucoma

2019 ◽  
Vol 10 (2) ◽  
Author(s):  
Hiroki Sano ◽  
Kazuhiko Namekata ◽  
Atsuko Kimura ◽  
Hiroshi Shitara ◽  
Xiaoli Guo ◽  
...  
Keyword(s):  
Retinal Degeneration ◽  
Mouse Models ◽  
Normal Tension Glaucoma ◽  
Differential Effects

scholarly journals Corrigendum to “Branched chain amino acids attenuate major pathologies in mouse models of retinal degeneration and glaucoma” [Heliyon 4(2) (March 2018) e00544]

Heliyon ◽  
2018 ◽  
Vol 4 (8) ◽  
pp. e00739
Author(s):  
Tomoko Hasegawa ◽  
Hanako Ohashi Ikeda ◽  
Sachiko Iwai ◽  
Yuki Muraoka ◽  
Tatsuaki Tsuruyama ◽  
...  
Keyword(s):  
Amino Acids ◽  
Retinal Degeneration ◽  
Mouse Models ◽  
Branched Chain Amino Acids ◽  
Branched Chain

scholarly journals TUDCA Slows Retinal Degeneration in Two Different Mouse Models of Retinitis Pigmentosa and Prevents Obesity in Bardet-Biedl Syndrome Type 1 Mice

2012 ◽  
Vol 53 (1) ◽  
pp. 100 ◽  
Author(s):  
Arlene V. Drack ◽  
Alina V. Dumitrescu ◽  
Sajag Bhattarai ◽  
Daniel Gratie ◽  
Edwin M. Stone ◽  
...  
Keyword(s):  
Retinitis Pigmentosa ◽  
Retinal Degeneration ◽  
Mouse Models ◽  
Syndrome Type ◽  
Bardet Biedl Syndrome
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