Oncogenes, Tumor Suppressor Genes and Apoptosis-Inducing Genes Utilized in Cancer Gene Therapy

2007 ◽  
pp. 173-184
Author(s):  
Lidong Zhang ◽  
Bingliang Fang
Keyword(s):  
Gene Therapy ◽  
Tumor Suppressor ◽  
Tumor Suppressor Genes ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Suppressor Genes

scholarly journals Gene Therapy Progress and Prospects: cancer gene therapy using tumour suppressor genes

Gene Therapy ◽  
2004 ◽  
Vol 11 (6) ◽  
pp. 497-503 ◽  
Author(s):  
IA McNeish ◽  
SJ Bell ◽  
NR Lemoine
Keyword(s):  
Gene Therapy ◽  
Cancer Gene Therapy ◽  
Tumour Suppressor ◽  
Tumour Suppressor Genes ◽  
Cancer Gene ◽  
Suppressor Genes

The tumor suppressor gene RIZ in cancer gene therapy (Review)

2002 ◽  
Author(s):  
Richard Canote ◽  
Yong Du ◽  
Tobias Carling ◽  
Fang Tian ◽  
Zhaohui Peng ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Cancer Gene Therapy ◽  
Cancer Gene

p53-Bad: A Novel Tumor Suppressor/Proapoptotic Factor Hybrid Directed to the Mitochondria for Ovarian Cancer Gene Therapy

2019 ◽  
Vol 16 (8) ◽  
pp. 3386-3398 ◽  
Author(s):  
Phong Lu ◽  
Katherine E. Redd Bowman ◽  
Sarah M. Brown ◽  
Madeline Joklik-Mcleod ◽  
Erica R. Vander Mause ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Gene Therapy ◽  
Tumor Suppressor ◽  
Cancer Gene Therapy ◽  
Cancer Gene

scholarly journals The Evolution of Human Cancer Gene Duplications across Mammals

2020 ◽  
Author(s):  
Marc Tollis ◽  
Aika K. Schneider-Utaka ◽  
Carlo C. Maley
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Tumor Suppressor Genes ◽  
Human Tumor ◽  
Suppressor Gene ◽  
Genetic Alterations ◽  
Gene Copy ◽  
Cancer Gene ◽  
Suppressor Genes ◽  
Copy Numbers

AbstractCancer is caused by genetic alterations that affect cellular fitness, and multicellular organisms have evolved mechanisms to suppress cancer such as cell cycle checkpoints and apoptosis. These pathways may be enhanced by the addition of tumor suppressor gene paralogs or deletion of oncogenes. To provide insights to the evolution of cancer suppression across the mammalian radiation, we estimated copy numbers for 548 human tumor suppressor gene and oncogene homologs in 63 mammalian genome assemblies. The naked mole rat contained the most cancer gene copies, consistent with the extremely low rates of cancer found in this species. We found a positive correlation between a species’ cancer gene copy number and it’s longevity, but not body size, contrary to predictions from Peto’s Paradox. Extremely long-lived mammals also contained more copies of caretaker genes in their genomes, suggesting that the maintenance of genome integrity is an essential form of cancer prevention in long-lived species. We found the strongest association between longevity and copy numbers of genes that are both germline and somatic tumor suppressor genes, suggesting selection has acted to suppress both hereditary and sporadic cancers. We also found a strong relationship between the number of tumor suppressor genes and the number of oncogenes in mammalian genomes, suggesting complex regulatory networks mediate the balance between cell proliferation and checks on tumor progression. This study is the first to investigate cancer gene expansions across the mammalian radiation and provides a springboard for potential human therapies based on evolutionary medicine.

Gene Therapy for Pancreatic Cancer Targeting the Genomic Alterations of Tumor Suppressor Genes using Replication-selective Oncolytic Adenovirus

Human Cell ◽  
2002 ◽  
Vol 15 (3) ◽  
pp. 138-150 ◽  
Author(s):  
Makoto Sunamura ◽  
Masaru Oonuma ◽  
Fuyuhiko Motoi ◽  
Hisashi Abe ◽  
Yukoh Saitoh ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Gene Therapy ◽  
Tumor Suppressor ◽  
Tumor Suppressor Genes ◽  
Oncolytic Adenovirus ◽  
Cancer Targeting ◽  
Genomic Alterations ◽  
Suppressor Genes
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