Monitoring Nanoparticle-Treated Hepatocarcinoma Cells for Apoptosis

2010 ◽  
pp. 167-172 ◽  
Author(s):  
Timothy M. Potter ◽  
Stephan T. Stern
Keyword(s):  
Hepatocarcinoma Cells

Biological and Surface Properties of C-Type Virus Particles Produced by Novikoff Ascites Hepatoma Cells

1977 ◽  
Vol 35 ◽  
pp. 388-389
Author(s):  
D.C. Hixson ◽  
J.C. Chan ◽  
J.M. Bowen ◽  
E.F. Walborg
Keyword(s):  
Surface Properties ◽  
Ricinus Communis ◽  
Rat Kidney ◽  
Leukemia Virus ◽  
Viral Envelope ◽  
Virus Particles ◽  
Chemically Induced ◽  
Sarcoma Virus ◽  
Hepatocarcinoma Cells ◽  
Type C

Several years ago Karasaki (1) reported the production of type C virus particles by Novikoff ascites hepatocarcinoma cells. More recently, Weinstein (2) has reported the presence of type C virus particles in cell cultures derived from transplantable and primary hepatocellular carcinomas. To date, the biological function of these virus and their significance in chemically induced hepatocarcinogenesis are unknown. The present studies were initiated to determine a possible role for type C virus particles in chemically induced hepatocarcinogenesis. This communication describes results of studies on the biological and surface properties of type C virus associated with Novikoff hepatocarcinoma cells.Ecotropic and xenotropic murine leukemia virus (MuLV) activity in ascitic fluid of Novikoff tumor-bearing rats was assayed in murine sarcoma virus transformed S+L- mouse cells and S+L- mink cells, respectively. The presence of sarcoma virus activity was assayed in non-virus-producing normal rat kidney (NRK) cells. Ferritin conjugates of concanavalin A (Fer-Con wheat germ agglutinin (Fer-WGA), and Ricinus communis agglutinins I and II (Fer-RCAI and Fer-RCAII) were used to probe the structure and topography of saccharide determinants present on the viral envelope.

Thymoquinone sensitizes human hepatocarcinoma cells to TRAIL-induced apoptosis via oxidative DNA damage

DNA Repair ◽  
2021 ◽  
pp. 103117
Author(s):  
Ruikui Zhang ◽  
Tao Wu ◽  
Peipei Zheng ◽  
Ming Liu ◽  
Guixiang Xu ◽  
...  
Keyword(s):  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Hepatocarcinoma Cells ◽  
Induced Apoptosis ◽  
Human Hepatocarcinoma Cells

scholarly journals Effect of Allium senescens Extract on Sorafenib Resistance in Hepatocarcinoma Cells

2021 ◽  
Vol 11 (8) ◽  
pp. 3696
Author(s):  
Sohyeon Park ◽  
Yoonjin Park ◽  
Heejong Shin ◽  
Boyong Kim ◽  
Seunggwan Lee
Keyword(s):  
Drug Resistance ◽  
Hepg2 Cells ◽  
High Performance ◽  
Quantitative Polymerase Chain Reaction ◽  
Mitochondrial Apoptosis ◽  
Coumaric Acid ◽  
Allium Species ◽  
Hepatocarcinoma Cells ◽  
Polymerase Chain ◽  
Resistant Cells

Although Allium species are involved in bioactivity, to the best of our knowledge, there is no research on the effects of Allium senescens on drug resistance in hepatocarcinoma. Ultra-high performance liquid chromatography was used to determine the concentration of several bioactive compounds in A. senescens extract; flow cytometry, reverse transcription–quantitative polymerase chain reaction, and siRNA-mediated knockdown to estimate the levels of different markers in HepG2 cells. The quantity of p-coumaric acid in the extract was 4.7291 ± 0.06 μg/mL, and the protein of relevant evolutionary and lymphoid interest (PRELI) in the resistant cells decreased 2.1 times in the presence of p-coumaric acid. The resistant cells strongly downregulated the efflux transporters (ABCB1, ABCC2, and ABCG2) when exposed to the extract or p-coumaric acid and when PRELI was knocked down, in contrast to the influx proteins (OCT-1). Additionally, the extract induced mitochondrial apoptosis and suppressed autophagy. Consequently, the extract and p-coumaric acid attenuated drug resistance of HepG2 cells through the downregulation of PRELI, a key protein associated with the modulation of drug transporter expression, the activation of autophagy, and mitochondrial apoptosis. Our results indicate that A. senescens extract is beneficial in protecting cancer cells against drug resistance and sustaining the efficacy of sorafenib against liver cancer.

scholarly journals miR-124-3p Suppresses the Invasiveness and Metastasis of Hepatocarcinoma Cells via Targeting CRKL

2020 ◽  
Vol 7 ◽  
Author(s):  
Abbasi Majid ◽  
Jinxia Wang ◽  
Muhammad Nawaz ◽  
Sattar Abdul ◽  
Munawar Ayesha ◽  
...  
Keyword(s):  
Hepatocarcinoma Cells

Lipid hydroperoxides from processed dietary oils enhance growth of hepatocarcinoma cells

2008 ◽  
Vol 52 (3) ◽  
pp. 352-359 ◽  
Author(s):  
Nataliya V. Rohr-Udilova ◽  
Klaus Stolze ◽  
Sandra Sagmeister ◽  
Hans Nohl ◽  
Rolf Schulte-Hermann ◽  
...  
Keyword(s):  
Lipid Hydroperoxides ◽  
Dietary Oils ◽  
Hepatocarcinoma Cells
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