scholarly journals Analysis of Photoreceptor Outer Segment Phagocytosis by RPE Cells in Culture

2012 ◽  
pp. 285-295 ◽  
Author(s):  
Yingyu Mao ◽  
Silvia C. Finnemann
Keyword(s):  
Outer Segment ◽  
Photoreceptor Outer Segment ◽  
Rpe Cells ◽  
Cells In Culture

scholarly journals Understanding photoreceptor outer segment phagocytosis: Use and utility of RPE cells in culture

2014 ◽  
Vol 126 ◽  
pp. 51-60 ◽  
Author(s):  
Francesca Mazzoni ◽  
Hussein Safa ◽  
Silvia C. Finnemann
Keyword(s):  
Outer Segment ◽  
Photoreceptor Outer Segment ◽  
Rpe Cells ◽  
Cells In Culture

Regulated efflux of photoreceptor outer segment-derived cholesterol by human RPE cells

2017 ◽  
Vol 165 ◽  
pp. 65-77 ◽  
Author(s):  
Federica Storti ◽  
Gabriele Raphael ◽  
Vera Griesser ◽  
Katrin Klee ◽  
Faye Drawnel ◽  
...  
Keyword(s):  
Outer Segment ◽  
Photoreceptor Outer Segment ◽  
Rpe Cells ◽  
Human Rpe Cells

scholarly journals Using Flow Cytometry to Compare the Dynamics of Photoreceptor Outer Segment Phagocytosis in iPS-Derived RPE Cells

2012 ◽  
Vol 53 (10) ◽  
pp. 6282 ◽  
Author(s):  
Peter D. Westenskow ◽  
Stacey K. Moreno ◽  
Tim U. Krohne ◽  
Toshihide Kurihara ◽  
Saiyong Zhu ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Outer Segment ◽  
Photoreceptor Outer Segment ◽  
Rpe Cells

scholarly journals Semaphorin4D-PlexinB1 Signaling Attenuates Photoreceptor Outer Segment Phagocytosis by Reducing Rac1 Activity of RPE Cells

2017 ◽  
Vol 55 (5) ◽  
pp. 4320-4332 ◽  
Author(s):  
Ayelen Bulloj ◽  
Arvydas Maminishkis ◽  
Masayuki Mizui ◽  
Silvia C. Finnemann
Keyword(s):  
Outer Segment ◽  
Photoreceptor Outer Segment ◽  
Rpe Cells ◽  
Rac1 Activity

Questioning photostasis

2013 ◽  
Vol 30 (4) ◽  
pp. 169-174 ◽  
Author(s):  
ALEXANDER CUNEA ◽  
RANA BEGUM ◽  
DIETER REINISCH ◽  
GLEN JEFFERY
Keyword(s):  
Statistical Analysis ◽  
Retinal Pigment Epithelium ◽  
Outer Segment ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Photoreceptor Outer Segment ◽  
Rpe Cells ◽  
Significant Difference ◽  
Environmental Lighting ◽  
Pigmentation Phenotype

AbstractPhotostasis is a phenomenon where the photoreceptor outer segment (OS) length and its rhodopsin content vary depending on environmental lighting. When light is reduced for extended periods, it is argued that OS lengthen and its rhodopsin concentration rises to increase photon capture in darker environment. Increases in OS length may occur because the retinal pigment epithelium (RPE) cells reduce OS consumption in prolonged darkness. But sample sizes in assessing changes in OS length have been small, and results highly varied with no statistical analysis ever offered. Further, animals used were often albinos, which have abnormal RPE cells. Here we keep pigmented and albino mice for 21 days in darkness and compare OS length with those in a normal 12:12 light/dark environment. We measured approximately 1300 OS but found no statistically significant difference in their lengths between light and dark groups in either pigmentation phenotype, although there was a small trend in the data favoring OS extension in the dark. Given that earlier studies were undertaken on limited samples with no statistical analysis, our data pose serious questions for the notion of mammalian photostasis in terms of significant OS plasticity.

scholarly journals Macular Pigment Optical Density and Photoreceptor Outer Segment Length as Predisease Biomarkers for Age-Related Macular Degeneration

2020 ◽  
Vol 9 (5) ◽  
pp. 1347 ◽  
Author(s):  
Norihiro Nagai ◽  
Sakiko Minami ◽  
Misa Suzuki ◽  
Hajime Shinoda ◽  
Toshihide Kurihara ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Optical Density ◽  
Outer Segment ◽  
Macular Pigment ◽  
Age Related Macular Degeneration ◽  
Segment Length ◽  
Macular Pigment Optical Density ◽  
Photoreceptor Outer Segment ◽  
Age Related ◽  
Fellow Eyes

To explore predisease biomarkers, which may help screen for the risk of age-related macular degeneration (AMD) at very early stages, macular pigment optical density (MPOD) and photoreceptor outer segment (PROS) length were analyzed. Thirty late AMD fellow eyes, which are at high risk and represent the predisease condition of AMD, were evaluated and compared with 30 age-matched control eyes without retinal diseases; there was no early AMD involvement in the AMD fellow eyes. MPOD was measured using MPS2® (M.E. Technica Co. Ltd., Tokyo, Japan), and PROS length was measured based on optical coherence tomography images. MPOD levels and PROS length in the AMD fellow eyes were significantly lower and shorter, respectively, than in control eyes. MPOD and PROS length were positively correlated in control eyes (R = 0.386; p = 0.035) but not in AMD fellow eyes. Twenty (67%) AMD fellow eyes met the criteria of MPOD < 0.65 and/or PROS length < 35 μm, while only five (17%) control eyes did. After adjusting for age and sex, AMD fellow eyes more frequently satisfied the definition (p < 0.001; 95% confidence interval, 3.50–60.4; odds ratio, 14.6). The combination of MPOD and PROS length may be a useful biomarker for screening predisease AMD patients, although further studies are required in this regard.

Reliability Assessment of a Rod Photoreceptor Outer Segment Grading System

2001 ◽  
Vol 72 (5) ◽  
pp. 573-579 ◽  
Author(s):  
Monica M Jablonski ◽  
Marshall J Graney ◽  
Stephen B Kritchevsky ◽  
Alessandro Iannaccone
Keyword(s):  
Outer Segment ◽  
Reliability Assessment ◽  
Grading System ◽  
Rod Photoreceptor ◽  
Photoreceptor Outer Segment

scholarly journals Correlation between brain volume and retinal photoreceptor outer segment volume in normal aging and neurodegenerative diseases

PLoS ONE ◽  
2020 ◽  
Vol 15 (9) ◽  
pp. e0237078
Author(s):  
Atsuro Uchida ◽  
Jagan A. Pillai ◽  
Robert Bermel ◽  
Stephen E. Jones ◽  
Hubert Fernandez ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Outer Segment ◽  
Brain Volume ◽  
Normal Aging ◽  
Photoreceptor Outer Segment ◽  
Retinal Photoreceptor ◽  
Segment Volume
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