A Computational Investigation of the Role of Ion Gradients in Signal Generation in Neurons

2018 ◽  
pp. 291-304
Author(s):  
Seyed Ali Sadegh Zadeh ◽  
Chandra Kambhampati
Keyword(s):  
Signal Generation ◽  
Computational Investigation ◽  
Ion Gradients

scholarly journals Non-Mammalian Vertebrates: Distinct Models to Assess the Role of Ion Gradients in Energy Expenditure

2017 ◽  
Vol 8 ◽  
Author(s):  
Caroline E. Geisler ◽  
Kyle P. Kentch ◽  
Benjamin J. Renquist
Keyword(s):  
Energy Expenditure ◽  
Ion Gradients

The Reaction Pathway of Cellulose Pyrolysis to a Multifunctional Chiral Building Block: The Role of Water Unveiled by a DFT Computational Investigation

ChemPhysChem ◽  
2016 ◽  
Vol 17 (23) ◽  
pp. 3948-3953 ◽  
Author(s):  
Tainah Dorina Marforio ◽  
Andrea Bottoni ◽  
Matteo Calvaresi ◽  
Daniele Fabbri ◽  
Pietro Giacinto ◽  
...  
Keyword(s):  
Building Block ◽  
Reaction Pathway ◽  
Computational Investigation ◽  
Cellulose Pyrolysis ◽  
Chiral Building Block

scholarly journals Advances in Electrochemical Aptasensors Based on Carbon Nanomaterials

Chemosensors ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 96
Author(s):  
Gennady Evtugyn ◽  
Anna Porfireva ◽  
Rezeda Shamagsumova ◽  
Tibor Hianik
Keyword(s):  
Carbon Nanotubes ◽  
Carbon Nitride ◽  
Carbon Nanomaterials ◽  
Carbon Materials ◽  
Signal Generation ◽  
Redox Activity ◽  
Electrochemical Biosensors ◽  
Future Prospects ◽  
Measurement Mode

Carbon nanomaterials offer unique opportunities for the assembling of electrochemical aptasensors due to their high electroconductivity, redox activity, compatibility with biochemical receptors and broad possibilities of functionalization and combination with other auxiliary reagents. In this review, the progress in the development of electrochemical aptasensors based on carbon nanomaterials in 2016–2020 is considered with particular emphasis on the role of carbon materials in aptamer immobilization and signal generation. The synthesis and properties of carbon nanotubes, graphene materials, carbon nitride, carbon black particles and fullerene are described and their implementation in the electrochemical biosensors are summarized. Examples of electrochemical aptasensors are classified in accordance with the content of the surface layer and signal measurement mode. In conclusion, the drawbacks and future prospects of carbon nanomaterials’ application in electrochemical aptasensors are briefly discussed.

Quality not quantity: Key success factors from the first decade of safety reports from the Research on Adverse Drug Events and Reports project (RADAR)

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 6559-6559
Author(s):  
C. Bennett ◽  
B. J. Edwards ◽  
C. C. Tigue ◽  
D. W. Raisch ◽  
D. M. Courtney ◽  
...  
Keyword(s):  
Drug Safety ◽  
Success Factors ◽  
Adverse Drug Events ◽  
Case Reports ◽  
Signal Generation ◽  
Drug Reactions ◽  
High Quality ◽  
Key Success Factors ◽  
Safety Signals

6559 Background: RADAR is the only independent academic pharmacovigilance organization funded exclusively by peer-reviewed grants. We describe the role of high quality case reports in the detection of drug safety signals. Methods: RADAR has identified 11 cancer-related adverse drug reactions (ADRs). Initial reports for small numbers of cases were obtained from our own institution, NU, (4 ADRs) or from referral centers (7 ADRs). Clinicians at these centers voluntarily provided brief case reports to RADAR, who submitted detailed case reports to the FDA/manufacturer. Clinicians were promised that patient/provider data would be kept confidential and that these data would be submitted as peer-reviewed manuscripts. Results: See Table. Conclusions: RADAR was successful at signal generation and amplification because it focused on quality, not quantity of case reports. Pharmacovigilance efforts that allow clinicians to complete brief forms, maintain confidentiality of patient and provider, and result in submission of collaborative manuscripts may improve early detection of drug safety signals initiatives in oncology. [Table: see text] No significant financial relationships to disclose.

Control of pollen tube growth: role of ion gradients and fluxes

2003 ◽  
Vol 159 (3) ◽  
pp. 539-563 ◽  
Author(s):  
Terena L. Holdaway-Clarke ◽  
Peter K. Hepler
Keyword(s):  
Pollen Tube ◽  
Pollen Tube Growth ◽  
Tube Growth ◽  
Ion Gradients

The role of Arginine 38 in horseradish peroxidase enzyme revisited: A computational investigation

2009 ◽  
Vol 141 (1) ◽  
pp. 87-93 ◽  
Author(s):  
Simone Tatoli ◽  
Costantino Zazza ◽  
Nico Sanna ◽  
Amedeo Palma ◽  
Massimiliano Aschi
Keyword(s):  
Horseradish Peroxidase ◽  
Computational Investigation ◽  
Peroxidase Enzyme
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