Modeling of Cornea Applanation When Measuring Eye Pressure

Features of the course and treatment of glaucoma during pregnancy

Clinical Medicine (Russian Journal) ◽

10.30629/0023-2149-2020-98-3-178-184 ◽

2020 ◽

Vol 98 (3) ◽

pp. 178-184

Author(s):

T. V. Chernyakova ◽

A. Yu. Brezhnev ◽

I. R. Gazizova ◽

A. V. Kuroyedov ◽

A. V. Seleznev

Keyword(s):

Pregnant Women ◽

Laser Treatment ◽

Progressive Disease ◽

Clinical Course ◽

The Other ◽

Third Trimester ◽

The Third ◽

Chronic Progressive Disease ◽

Hypotensive Therapy ◽

Eye Pressure

In the review we have integrated all up-to-date knowledge concerning clinical course and treatment of glaucoma among pregnant women to help specialists choose a proper policy of treatment for such a complicated group of patients. Glaucoma is a chronic progressive disease. It rarely occurs among childbearing aged women. Nevertheless the probability to manage pregnant patients having glaucoma has been recently increasing. The situation is complicated by the fact that there are no recommendations on how to treat glaucoma among pregnant women. As we know, eye pressure is progressively going down from the first to the third trimester, so we often have to correct hypotensive therapy. Besides, it is necessary to take into account the effect of applied medicines on mother health and evaluate possible teratogenic complications for a fetus. The only medicine against glaucoma which belongs to category B according to FDA classification is brimonidine. Medicines of the other groups should be prescribed with care. Laser treatment or surgery may also be a relevant decision when monitoring patients who are planning pregnancy or just bearing a child. Such treatment should be also accompanied by medicines.

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Evaluation of the anti- Acanthamoeba activity of two commercial eye drops commonly used to lower eye pressure

Experimental Parasitology ◽

10.1016/j.exppara.2017.07.012 ◽

2017 ◽

Vol 183 ◽

pp. 117-123 ◽

Cited By ~ 3

Author(s):

Ines Sifaoui ◽

María Reyes-Batlle ◽

Atteneri López-Arencibia ◽

Carolina Wagner ◽

Olfa Chiboub ◽

...

Keyword(s):

Eye Drops ◽

Eye Pressure

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Methodology of eye pressure measurement

Biorheology ◽

10.3233/bir-1969-6105 ◽

1969 ◽

Vol 6 (1) ◽

pp. 37-45 ◽

Cited By ~ 1

Author(s):

Frank J. Macri ◽

Richard F. Brubaker

Keyword(s):

Pressure Measurement ◽

Eye Pressure

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Optogenetic stimulation of phosphoinositides reveals a critical role of primary cilia in eye pressure regulation

Science Advances ◽

10.1126/sciadv.aay8699 ◽

2020 ◽

Vol 6 (18) ◽

pp. eaay8699

Author(s):

Philipp P. Prosseda ◽

Jorge A. Alvarado ◽

Biao Wang ◽

Tia J. Kowal ◽

Ke Ning ◽

...

Keyword(s):

Aqueous Humor ◽

Primary Cilia ◽

Vision Loss ◽

Critical Role ◽

Calcium Dependent ◽

Aqueous Humor Outflow ◽

Trabecular Meshwork Cells ◽

Eye Pressure ◽

Stimulation Of

Glaucoma is a group of progressive optic neuropathies that cause irreversible vision loss. Although elevated intraocular pressure (IOP) is associated with the development and progression of glaucoma, the mechanisms for its regulation are not well understood. Here, we have designed CIBN/CRY2-based optogenetic constructs to study phosphoinositide regulation within distinct subcellular compartments. We show that stimulation of CRY2-OCRL, an inositol 5-phosphatase, increases aqueous humor outflow and lowers IOP in vivo, which is caused by a calcium-dependent actin rearrangement of the trabecular meshwork cells. Phosphoinositide stimulation also rescues defective aqueous outflow and IOP in a Lowe syndrome mouse model but not in IFT88fl/fl mice that lack functional cilia. Thus, our study is the first to use optogenetics to regulate eye pressure and demonstrate that tight regulation of phosphoinositides is critical for aqueous humor homeostasis in both normal and diseased eyes.

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Brimonidine and Eye Pressure

Ophthalmology ◽

10.1016/j.ophtha.2010.03.075 ◽

2010 ◽

Vol 117 (7) ◽

pp. 1463

Author(s):

Mohammad Hosein Nowroozzadeh ◽

M. Reza Razeghinejad

Keyword(s):

Eye Pressure

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Tactile Eye Pressure Measurement Through the Eyelid

Volume 3: Biomedical and Biotechnology Engineering ◽

10.1115/imece2015-50875 ◽

2015 ◽

Cited By ~ 1

Author(s):

Eniko T. Enikov ◽

Péter P. Polyvás ◽

Gholam Peyman ◽

Sean Mccafferty

Keyword(s):

Intraocular Pressure ◽

Human Subjects ◽

Statistical Error ◽

Applanation Tonometry ◽

Tactile Sensors ◽

Non Invasive ◽

Digital Palpation ◽

Early Results ◽

Novel Method ◽

Eye Pressure

This article presents the early results from a 10-person human subject study evaluating the accuracy of a novel method of indirect estimation of intraocular pressure using tactile sensors. Manual digital palpation tonometery is an old method used to estimate the eye pressure through palpation with ones fingers. Based on this concept, we present an instrumented measurement method, where multiple tactile stiffness sensors are used to infer the intraocular pressure of the eye. The method is validated using experimental data gathered from human subjects with eye pressures from 15 to 22 mmHg and determined by Goldman applanation tonometry (GAT). Bland-Altman plots comparing the GAT measurements and the proposed through-the-eye-lid tonometry indicate a statistical error of 5.16 mmHg, within the 95% confidence interval, which compares favorably with the FDA-mandated error bound of 5 mmHg. Details on the unit operation and data filtering are also presented. Due to its indirect and non-invasive nature, the proposed new tactile tonometry method can be applied at home as a self-administered home tonometer for management of glaucoma.

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