A Novel Approach to Blockchain-Based Digital Identity System

Purpose This conceptual article’s primary aim is to identify the significant stakeholders of the digital identity system (DIS) and then highlight the impact of artificial intelligence (AI) on each of the identified stakeholders. It also recommends vital points that could be considered by policymakers while developing technology-related policies for effective DIS. Design/methodology/approach This article uses stakeholder methodology and design theory (DT) as a primary theoretical lens along with the innovation diffusion theory (IDT) as a sub-theory. This article is based on the analysis of existing literature that mainly comprises academic literature, official reports, white papers and publicly available domain experts’ interviews. Findings The study identified six significant stakeholders, i.e. government, citizens, infrastructure providers, identity providers (IdP), judiciary and relying parties (RPs) of the DIS from the secondary data. Also, the role of IdP becomes insignificant in the context of AI-enabled digital identity systems (AIeDIS). The findings depict that AIeDIS can positively impact the DIS stakeholders by solving a range of problems such as identity theft, unauthorised access and credential misuse, and will also open a possibility of new ways to empower all the stakeholders. Research limitations/implications The study is based on secondary data and has considered DIS stakeholders from a generic perspective. Incorporating expert opinion and empirical validation of the hypothesis could derive more specific and context-aware insights. Practical implications The study could facilitate stakeholders to enrich further their understanding and significance of developing sustainable and future-ready DIS by highlighting the impact of AI on the digital identity ecosystem. Originality/value To the best of the authors’ knowledge, this article is the first of its kind that has used stakeholder theory, DT and IDT to explain the design and developmental phenomenon of AIeDIS. A list of six significant stakeholders of DIS, i.e. government, citizens, infrastructure providers, IdP, judiciary and RP, is identified through comprehensive literature analysis.

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A Novel Approach to Manage Ownership and VAT Using Blockchain-Based Digital Identity

Ubiquitous Networking - Lecture Notes in Computer Science ◽

10.1007/978-3-030-86356-2_21 ◽

2021 ◽

pp. 255-268

Author(s):

S. M. Maksudul Alam ◽

Md Abdullah Al Mamun ◽

Md Shohrab Hossain ◽

M. Samiruzzaman

Keyword(s):

Digital Identity ◽

Novel Approach

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Use of single digital identity system at the central government level, 2019

Government at a Glance: Western Balkans ◽

10.1787/26e41512-en ◽

2020 ◽

Keyword(s):

Central Government ◽

Digital Identity ◽

Identity System ◽

Government Level

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Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

Biochemical Journal ◽

10.1042/bcj20190591 ◽

2019 ◽

Vol 476 (24) ◽

pp. 3705-3719 ◽

Cited By ~ 2

Author(s):

Avani Vyas ◽

Umamaheswar Duvvuri ◽

Kirill Kiselyov

Keyword(s):

Oxidative Stress ◽

Head And Neck ◽

Transcriptional Activation ◽

Platinum Resistance ◽

Mrna Levels ◽

Strong Positive Correlation ◽

Platinum Compounds ◽

Copper Chelation ◽

Novel Approach ◽

Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

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Collecting Words: A Clinical Example of a Morphology-Focused Orthographic Intervention

Language Speech and Hearing Services in Schools ◽

10.1044/2020_lshss-19-00050 ◽

2020 ◽

Vol 51 (3) ◽

pp. 544-560 ◽

Cited By ~ 3

Author(s):

Kimberly A. Murphy ◽

Emily A. Diehm

Keyword(s):

Written Language ◽

Morphological Knowledge ◽

English Orthography ◽

Word Level ◽

Novel Approach ◽

Language Pathology ◽

The One ◽

Critical Intervention ◽

Reading And Spelling ◽

Reading And Spelling Difficulties

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687

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