Genetic and Molecular Basis of Cardiac Arrhythmias

2020 ◽  
pp. 75-96
Author(s):  
Sylvia Marie R. Biso ◽  
Niyada Naksuk ◽  
Dawood Darbar
Keyword(s):  
Cardiac Arrhythmias ◽  
Molecular Basis

scholarly journals Genetic and Molecular Basis of Cardiac Arrhythmias: Impact on Clinical Management Parts I and II

Circulation ◽  
1999 ◽  
Vol 99 (4) ◽  
pp. 518-528 ◽  
Author(s):  
Silvia G. Priori ◽  
Jacques Barhanin ◽  
Richard N. W. Hauer ◽  
Wilhelm Haverkamp ◽  
Habo J. Jongsma ◽  
...  
Keyword(s):  
Cardiac Arrhythmias ◽  
Clinical Management ◽  
Molecular Basis

scholarly journals The Link Between Sex Hormones and Susceptibility to Cardiac Arrhythmias: From Molecular Basis to Clinical Implications

2021 ◽  
Vol 8 ◽  
Author(s):  
Sarah Costa ◽  
Ardan M. Saguner ◽  
Alessio Gasperetti ◽  
Deniz Akdis ◽  
Corinna Brunckhorst ◽  
...  
Keyword(s):  
Sex Hormones ◽  
Cardiac Arrhythmias ◽  
Molecular Basis ◽  
Conduction System ◽  
Cardiac Conduction ◽  
Clinical Implications ◽  
Cardiac Ion Channels ◽  
Increased Risk ◽  
Qt Syndrome ◽  
Underlying Mechanisms

It is well-known that gender is an independent risk factor for some types of cardiac arrhythmias. For example, males have a greater prevalence of atrial fibrillation and the Brugada Syndrome. In contrast, females are at increased risk for the Long QT Syndrome. However, the underlying mechanisms of these gender differences have not been fully identified. Recently, there has been accumulating evidence indicating that sex hormones may have a significant impact on the cardiac rhythm. In this review, we describe in-depth the molecular interactions between sex hormones and the cardiac ion channels, as well as the clinical implications of these interactions on the cardiac conduction system, in order to understand the link between these hormones and the susceptibility to arrhythmias.

scholarly journals Genetic and Molecular Basis of Cardiac Arrhythmias: Impact on Clinical Management Part III

Circulation ◽  
1999 ◽  
Vol 99 (5) ◽  
pp. 674-681 ◽  
Author(s):  
Silvia G. Priori ◽  
Jacques Barhanin ◽  
Richard N. W. Hauer ◽  
Wilhelm Haverkamp ◽  
Habo J. Jongsma ◽  
...  
Keyword(s):  
Cardiac Arrhythmias ◽  
Clinical Management ◽  
Molecular Basis

The molecular basis of cardiac arrhythmias in patients with cardiomyopathy

2004 ◽  
Vol 1 (3) ◽  
pp. 98-103 ◽  
Author(s):  
Sen Ji ◽  
David Cesario ◽  
Miguel Valderrabano ◽  
Kalyanam Shivkumar
Keyword(s):  
Cardiac Arrhythmias ◽  
Molecular Basis

Expression and coassociation of ERG1, KCNQ1, and KCNE1 potassium channel proteins in horse heart

2002 ◽  
Vol 283 (1) ◽  
pp. H126-H138 ◽  
Author(s):  
Melissa R. Finley ◽  
Yan Li ◽  
Fei Hua ◽  
James Lillich ◽  
Kathy E. Mitchell ◽  
...  
Keyword(s):  
Cardiac Arrhythmias ◽  
Molecular Basis ◽  
Cardiac Tissue ◽  
Delayed Rectifier ◽  
Related Gene ◽  
Rt Pcr ◽  
Delayed Rectifier Current ◽  
Cardiac Action ◽  
Qt Syndrome ◽  
Α Subunits

In dogs and in humans, potassium channels formed by ether-a-go-go-related gene 1 protein ERG1 (KCNH2) and KCNQ1 α-subunits, in association with KCNE β-subunits, play a role in normal repolarization and may contribute to abnormal repolarization associated with long QT syndrome (LQTS). The molecular basis of repolarization in horse heart is unknown, although horses exhibit common cardiac arrhythmias and may receive drugs that induce LQTS. In horse heart, we have used immunoblotting and immunostaining to demonstrate the expression of ERG1, KCNQ1, KCNE1, and KCNE3 proteins and RT-PCR to detect KCNE2 message. Peptide N-glycosidase F-sensitive forms of horse ERG1 (145 kDa) and KCNQ1 (75 kDa) were detected. Both ERG1 and KCNQ1 coimmunoprecipitated with KCNE1. Cardiac action potential duration was prolonged by antagonists of either ERG1 (MK-499, cisapride) or KCNQ1/KCNE1 (chromanol 293B). Patch-clamp analysis confirmed the presence of a slow delayed rectifier current. These data suggest that repolarizing currents in horses are similar to those of other species, and that horses are therefore at risk for acquired LQTS. The data also provide unique evidence for coassociation between ERG1 and KCNE1 in cardiac tissue.

Renilla Bioluminescence: A Morphologic Approach to the Location of Photocytes

1974 ◽  
Vol 32 ◽  
pp. 208-209
Author(s):  
Ben O. Spurlock ◽  
Milton J. Cormier
Keyword(s):  
Excited State ◽  
Ground State ◽  
Molecular Basis ◽  
Light Emission ◽  
Chemical Basis ◽  
Electronic Excited State ◽  
Colonial Form ◽  
The Common ◽  
Eighteenth And Nineteenth Centuries ◽  
Catalyzed Oxidation

The phenomenon of bioluminescence has fascinated layman and scientist alike for many centuries. During the eighteenth and nineteenth centuries a number of observations were reported on the physiology of bioluminescence in Renilla, the common sea pansy. More recently biochemists have directed their attention to the molecular basis of luminosity in this colonial form. These studies have centered primarily on defining the chemical basis for bioluminescence and its control. It is now established that bioluminescence in Renilla arises due to the luciferase-catalyzed oxidation of luciferin. This results in the creation of a product (oxyluciferin) in an electronic excited state. The transition of oxyluciferin from its excited state to the ground state leads to light emission.

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