FDG PET Hybrid Imaging

Abstract Nuclear imaging is used in the evaluation of painful arthroplasties for diagnosing loosening or periprosthetic joint infection (PJI). The purpose of this systematic review is to depict the reproducibility of the various nuclear imaging modalities used in the assessment of painful hip and knee arthroplasties. A systematic review of the literature was conducted with a comprehensive search of MEDLINE to identify clinical studies investigating the intra-and inter-observer agreement of nuclear imaging modalities in diagnosing PJI and mechanical loosening. A total of 3.000 studies, published between 2004 and 2020, were reviewed and 16 studies met the inclusion criteria. Quality assessment identified concerns with regard to the internal validity in approximately 40% of the included studies. A meta-analysis could not be performed because of insufficient available clinical data. The intra-observer agreement was poorly investigated. The included studies reported an inter-observer agreement of “slight” to “excellent” for bone scintigraphy, “moderate” to “substantial” for leukocyte scintigraphy, “substantial” to “almost perfect” for combined leukocyte and bone marrow scintigraphy, and “fair” to “substantial” for anti-granulocyte scintigraphy. Hybrid imaging with SPECT/CT and FDG-PET/CT demonstrated “substantial” and “almost perfect” inter-observer agreement for symptomatic hip prostheses, respectively. The reproducibility of nuclear imaging is underreported in clinical studies investigating painful knee and hip arthroplasties. Moreover, the included studies demonstrated methodological concerns with a high risk of bias. The available evidence demonstrated a wide range of inter-observer agreement using scintigraphy. Hybrid imaging with SPECT/CT and FDG-PET/CT may improve the accuracy of interpretation and reproducibility. However, literature provides limited data to support this assumption.

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Electrocardiogram-Gated 18F-FDG PET/CT Hybrid Imaging in Patients with Unsatisfactory Response to Cardiac Resynchronization Therapy: Initial Clinical Results

Journal of Nuclear Medicine ◽

10.2967/jnumed.110.078709 ◽

2010 ◽

Vol 52 (1) ◽

pp. 67-71 ◽

Cited By ~ 23

Author(s):

C. Uebleis ◽

M. Ulbrich ◽

R. Tegtmeyer ◽

F. Schuessler ◽

N. Haserueck ◽

...

Keyword(s):

Cardiac Resynchronization Therapy ◽

Fdg Pet ◽

Hybrid Imaging ◽

Clinical Results ◽

Cardiac Resynchronization ◽

Resynchronization Therapy ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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PET/CT imaging for evaluation of multimodal treatment efficacy and toxicity in advanced NSCLC—current state and future directions

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-021-05211-8 ◽

2021 ◽

Author(s):

Chukwuka Eze ◽

Nina-Sophie Schmidt-Hegemann ◽

Lino Morris Sawicki ◽

Julian Kirchner ◽

Olarn Roengvoraphoj ◽

...

Keyword(s):

Treatment Efficacy ◽

Fdg Pet ◽

Hybrid Imaging ◽

Advanced Nsclc ◽

Response Assessment ◽

Response Criteria ◽

Future Directions ◽

Current State ◽

Pet Ct ◽

Fdg Pet Ct

Abstract Purpose The advent of immune checkpoint inhibitors (ICIs) has revolutionized the treatment of advanced NSCLC, leading to a string of approvals in recent years. Herein, a narrative review on the role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in the ever-evolving treatment landscape of advanced NSCLC is presented. Methods This comprehensive review will begin with an introduction into current treatment paradigms incorporating ICIs; the evolution of CT-based criteria; moving onto novel phenomena observed with ICIs and the current state of hybrid imaging for diagnosis, treatment planning, evaluation of treatment efficacy and toxicity in advanced NSCLC, also taking into consideration its limitations and future directions. Conclusions The advent of ICIs marks the dawn of a new era bringing forth new challenges particularly vis-à-vis treatment response assessment and observation of novel phenomena accompanied by novel systemic side effects. While FDG PET/CT is widely adopted for tumor volume delineation in locally advanced disease, response assessment to immunotherapy based on current criteria is of high clinical value but has its inherent limitations. In recent years, modifications of established (PET)/CT criteria have been proposed to provide more refined approaches towards response evaluation. Not only a comprehensive inclusion of PET-based response criteria in prospective randomized controlled trials, but also a general harmonization within the variety of PET-based response criteria is pertinent to strengthen clinical implementation and widespread use of hybrid imaging for response assessment in NSCLC.

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Multiple Vertebral Hemangiomas Mimicking Metastases in a Patient with Renal Carcinoma: Importance of Hybrid Imaging with SPECT/CT and FDG PET/CT

Journal of Postgraduate Medicine Education and Research ◽

10.5005/jp-journals-10028-1044 ◽

2012 ◽

Vol 46 (4) ◽

pp. 196-197

Author(s):

BR Mittal ◽

A Bhattacharya ◽

K Manohar ◽

RVR Parghane ◽

S Kumari ◽

...

Keyword(s):

Computed Tomography ◽

Fdg Pet ◽

Hybrid Imaging ◽

Renal Carcinoma ◽

Photon Emission ◽

Benign Tumors ◽

Emission Computed Tomography ◽

Pet Ct ◽

Fdg Pet Ct ◽

Vertebral Hemangiomas

ABSTRACT Vertebral hemangiomas are the most common benign tumors of the spine and usually present as cold defects on skeletal scintigraphy. However, these lesions may rarely show uptake of Tc-99m methylene diphosphonate, mimicking metastases. In this patient with renal carcinoma, abnormal vertebral tracer uptake (indicative of skeletal metastases on planar bone scintigraphy) was subsequently localized to vertebral lesions identified as hemangiomas on the CT component of single photon emission computed tomography/computed tomography (SPECT/CT). None of these hemangiomas showed any uptake of F-18 fluorodeoxyglucose on positron emission tomography/ computed tomography (PET/CT). How to cite this article Manohar K, Parghane RVR, Kumari S, Bhattacharya A, Mandal AK, Mittal BR. Multiple Vertebral Hemangiomas Mimicking Metastases in a Patient with Rena Carcinoma: Importance of Hybrid Imaging with SPECT/CT and FDG PET/CT. J Postgrad Med Edu Res 2012;46(4):196-197.

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Incidental and simultaneous finding of pulmonary thrombus and COVID-19 pneumonia in a cancer patient derived to 18F-FDG PET/CT. New pathophysiological insights from hybrid imaging

Radiology Case Reports ◽

10.1016/j.radcr.2020.07.032 ◽

2020 ◽

Vol 15 (10) ◽

pp. 1803-1805 ◽

Cited By ~ 1

Author(s):

Federico Ferrando-Castagnetto ◽

Cristina Gamila Wakfie-Corieh ◽

Alba María Blanes García ◽

Martha García García-Esquinas ◽

Rosa María Couto Caro ◽

...

Keyword(s):

Cancer Patient ◽

Fdg Pet ◽

Hybrid Imaging ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Impact of improved attenuation correction on 18F-FDG PET/MR hybrid imaging of the heart

PLoS ONE ◽

10.1371/journal.pone.0214095 ◽

2019 ◽

Vol 14 (3) ◽

pp. e0214095 ◽

Cited By ~ 6

Author(s):

Maike E. Lindemann ◽

Felix Nensa ◽

Harald H. Quick

Keyword(s):

Attenuation Correction ◽

Fdg Pet ◽

Hybrid Imaging ◽

18F Fdg

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The role of hybrid FDG-PET/MRI on decision-making in presurgical evaluation of drug-resistant epilepsy

BMC Neurology ◽

10.1186/s12883-021-02352-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Márton Tóth ◽

Péter Barsi ◽

Zoltán Tóth ◽

Katalin Borbély ◽

János Lückl ◽

...

Keyword(s):

Decision Making ◽

Fdg Pet ◽

Hybrid Imaging ◽

Clinical Decision Making ◽

Trial Registration ◽

Epileptogenic Zone ◽

Drug Resistant ◽

Presurgical Evaluation ◽

Resective Surgery ◽

Epileptogenic Lesion

Abstract Background When MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable outcome after epilepsy surgery becomes significantly lower (from 60 to 90% to 20–65%). Hybrid FDG-PET/MRI may provide additional information for identifying the epileptogenic zone. We aimed to investigate the possible effect of the introduction of hybrid FDG-PET/MRI into the algorithm of the decision-making in both lesional and non-lesional drug-resistant epileptic patients. Methods In a prospective study of patients suffering from drug-resistant focal epilepsy, 30 nonlesional and 30 lesional cases with discordant presurgical results were evaluated using hybrid FDG-PET/MRI. Results The hybrid imaging revealed morphological lesion in 18 patients and glucose hypometabolism in 29 patients within the nonlesional group. In the MRI positive group, 4 patients were found to be nonlesional, and in 9 patients at least one more epileptogenic lesion was discovered, while in another 17 cases the original lesion was confirmed by means of hybrid FDG-PET/MRI. As to the therapeutic decision-making, these results helped to indicate resective surgery instead of intracranial EEG (iEEG) monitoring in 2 cases, to avoid any further invasive diagnostic procedures in 7 patients, and to refer 21 patients for iEEG in the nonlesional group. Hybrid FDG-PET/MRI has also significantly changed the original therapeutic plans in the lesional group. Prior to the hybrid imaging, a resective surgery was considered in 3 patients, and iEEG was planned in 27 patients. However, 3 patients became eligible for resective surgery, 6 patients proved to be inoperable instead of iEEG, and 18 cases remained candidates for iEEG due to the hybrid FDG-PET/MRI. Two patients remained candidates for resective surgery and one patient became not eligible for any further invasive intervention. Conclusions The results of hybrid FDG-PET/MRI significantly altered the original plans in 19 of 60 cases. The introduction of hybrid FDG-PET/MRI into the presurgical evaluation process had a potential modifying effect on clinical decision-making. Trial registration Trial registry: Scientific Research Ethics Committee of the Medical Research Council of Hungary. Trial registration number: 008899/2016/OTIG. Date of registration: 08 February 2016.

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