Selective Transport of Suspending Micro-Particles in an Oscillating Fluid Through Micro-Channels

2021 ◽  
pp. 123-135
Author(s):  
Philippe Beltrame
Keyword(s):  
Selective Transport ◽  
Micro Particles ◽  
Micro Channels

scholarly journals Selective Transport of Airborne Microparticles Through Micro-channels Under Microgravity

2021 ◽  
Vol 33 (1) ◽  
Author(s):  
Monia Makhoul ◽  
Philippe Beltrame
Keyword(s):  
Numerical Simulation ◽  
Fluid Flow ◽  
Bifurcation Analysis ◽  
Metal Particles ◽  
Microgravity Environment ◽  
Ratchet Effect ◽  
Selective Transport ◽  
Microgravity Experiments ◽  
Particle Drift ◽  
Micro Channels

AbstractThis paper analyzes the possibility of obtaining the selective transport of microparticles suspended in air in a microgravity environment through modulated channels without net displacement of air. Using numerical simulation and bifurcation analysis tools, we show the existence of intermittent particle drift under the Stokes assumption of the fluid flow. The particle transport can be selective and the direction of transport is controlled only by the kind of pumping used. The selective transport is interpreted as a deterministic ratchet effect due to spatial variations in the flow and the particle drag. This ratchet phenomenon could be applied to the selective transport of metal particles during the short duration of microgravity experiments.

Physics Based Simulation of Large Size Particle Transport in Biomedical Applications

2012 ◽  
Author(s):  
Zhijian Chen ◽  
Andrzej Przekwas ◽  
Mahesh Athavale
Keyword(s):  
Fluid Transport ◽  
Control Volume ◽  
Particle Surface ◽  
Fluid Pressure ◽  
Lagrangian Model ◽  
Micro Particles ◽  
Computational Mesh ◽  
Micro Channels ◽  
Background Mesh ◽  
Physics Based Simulation

In biomedical microdevices and medical applications there is a need to analyze fluid transport of solid structures with sizes comparable to channel dimensions. Examples include manipulation of biological cells in microfluidic devices or transport of thrombin particles in blood vessels. Computational modeling of such macroparticles is very difficult when the particle size is bigger than the size of the computational control volume (mesh element). In performing such simulations, conventional Lagrangian model of micro particles is not suitable since this approach doesn’t account particle’s volume blockage of the supporting Eulerian computational mesh. Other approaches such as deforming mesh or volume of fluid are either impractical of computationally very intensive or limited to structured meshes. We have developed a ‘macroparticle’ methodology where the large particle is represented as a large cluster of smaller particles (marker particles) that is “embedded” on a background computational grid. The macroparticle is then represented by blocking the cells in the background mesh that are overlapped by individual micro-particles. The discrete surface of the macroparticle is represented by partially or fully blocked cells of the background computational mesh. The translation /rotation/deformation motion of the macroparticle is calculated using a 6-DOF model with fluid pressure and shear forces acting on the particle surface used as forces and moments in calculating macroparticle position, velocity, acceleration and rotation. The size of the background grid determines the accuracy of the particle shape definition and the flow solution. The relevant physics and chemical conservation laws for each macroparticle are solved in a coupled, iterative method with the equation systems governing the background fluid domain. This methodology has been successfully used for simulations of macroparticle-laden fluids in micro channels in biochips. As an application of this novel method, we have applied this technology to simulate a moving clot in blood flow and process of clot mechanical dissolution (thrombolysis).

Numerical Study on Delivery of Micro Particles Hydrodynamically Focused in Micro Channels

2019 ◽  
Author(s):  
Dingpeng Huang ◽  
Hangzhou Wang ◽  
Xiaoping Wang ◽  
Zexia Qiu ◽  
Ziqiang Ren
Keyword(s):  
Numerical Study ◽  
Micro Particles ◽  
Micro Channels

The Effect of Micro-Particles of Linoleic Acid Emulsion on the Blood-Brain Barrier in Cats

2004 ◽  
Vol 51 (5) ◽  
pp. 481
Author(s):  
Hak Jin Kim ◽  
Chang Hun Lee ◽  
Yong Seon Pyun ◽  
Tea Hong Lee
Keyword(s):  
Linoleic Acid ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Micro Particles ◽  
Blood Brain ◽  
Linoleic Acid Emulsion

Synthesis of Calcium Carbonate Micro Particles using Emulsion Membrane Process Applied for Drug Release Studies

2017 ◽  
Vol 68 (10) ◽  
pp. 2320-2324
Author(s):  
Mariana Mateescu ◽  
Sanda Maria Doncea ◽  
Irina Chican ◽  
Cristina Lavinia Nistor ◽  
Ioneta Codrina Bujanca
Keyword(s):  
Light Scattering ◽  
Calcium Carbonate ◽  
Dynamic Light Scattering ◽  
Liquid Membranes ◽  
Membrane Process ◽  
Emulsion Method ◽  
Micro Particles ◽  
Release Studies ◽  
Emulsion Liquid Membranes ◽  
Span 80

The aim of this work is the synthesis of calcium carbonate (CaCO3) nano and microparticles and their application as biomaterials (vehicles) for the sustained release of doxycycline. CaCO3 micro particles were synthesized by water-in oil (W/O) emulsion method using emulsion liquid membranes with bis (2-ethylhexyl) phosphate (D2EHPA) as carrier, Span 80 as surfactant, and toluene and kerosene as organic solvents. The aqueous phases contained 1 M CaCl2, and 1 M Na2CO3, respectively. The Dynamic Light Scattering (DLS) data showed CaCO3 particles with sizes ranging from around 100 nm to 3500 nm. The CaCO3 particles with the average diameters around 600 nm attained an adsorbtion of doxycycline of maximum 97.9%, and a slow and steady release with a cumulative value of approximative 50% after ten days.

Application of Nano- and Micro-Particles on the Topical Therapy of Skin-Related Immune Disorders

2015 ◽  
Vol 21 (19) ◽  
pp. 2643-2667 ◽  
Author(s):  
Lin Sun ◽  
Zeyu Liu ◽  
Dongmei Cun ◽  
Henry Tong ◽  
Ying Zheng
Keyword(s):  
Topical Therapy ◽  
Immune Disorders ◽  
Micro Particles
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