AbstractThis work aims to review literature related to the latest cyber-physical systems (CPS) for manufacturing in the revolutionary Industry 4.0 for a comprehensive understanding of the challenges, approaches, and used techniques in this domain. Different published studies on CPS for manufacturing in Industry 4.0 paradigms through 2010 to 2019 were searched and summarized. We, then, analyzed the studies at a different granularity level inspecting the title, abstract, and full text to include in the prospective study list. Out of 626 primarily extracted relevant articles, we scrutinized 78 articles as the prospective studies on CPS for manufacturing in Industry 4.0. First, we analyzed the articles’ context to identify the major components along with their associated fine-grained constituents of Industry 4.0. Then, we reviewed different studies through a number of synthesized matrices to narrate the challenges, approaches, and used techniques as the key-enablers of the CPS for manufacturing in Industry 4.0. Although the key technologies of Industry 4.0 are the CPS, Internet of Things (IoT), and Internet of Services (IoS), the human component (HC), cyber component (CC), physical component (PC), and their HC-CC, CC-PC, and HC-PC interfaces need to be standardized to achieve the success of Industry 4.0.
Digital Twins in Pharmaceutical and Biopharmaceutical Manufacturing: A Literature Review
