Ongoing Clinical Studies and Future Directions

2021 ◽  
pp. 351-370
Author(s):  
Azadeh Nasrazadani ◽  
Juan Luis Gomez Marti ◽  
Tara Hyder ◽  
Vikram Gorantla ◽  
Adam M. Brufsky
Keyword(s):  
Clinical Studies ◽  
Future Directions

Hormono-biological therapy in metastatic breast cancer: preclinical evidence, clinical studies and future directions

2008 ◽  
Vol 8 (2) ◽  
pp. 221-234 ◽  
Author(s):  
Giuseppe Tonini ◽  
Gaia Schiavon ◽  
Maria Elisabetta Fratto ◽  
Bruno Vincenzi ◽  
Daniele Santini
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Clinical Studies ◽  
Biological Therapy ◽  
Metastatic Breast ◽  
Future Directions

scholarly journals Letter by Makkar et al Regarding Article, “Cell Therapy for Heart Failure: A Comprehensive Overview of Experimental and Clinical Studies, Current Challenges, and Future Directions”

2014 ◽  
Vol 115 (11) ◽  
Author(s):  
Raj R. Makkar ◽  
Rachel R. Smith ◽  
Lawrence S.C. Czer ◽  
Stuart D. Russell ◽  
Gary Gerstenblith ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cell Therapy ◽  
Clinical Studies ◽  
Comprehensive Overview ◽  
Future Directions

Hyaluronic Acid Viscosupplementation and Osteoarthritis

2009 ◽  
Vol 37 (8) ◽  
pp. 1636-1644 ◽  
Author(s):  
Eric J. Strauss ◽  
Jennifer A. Hart ◽  
Mark D. Miller ◽  
Roy D. Altman ◽  
Jeffrey E. Rosen
Keyword(s):  
Hyaluronic Acid ◽  
Knee Osteoarthritis ◽  
Clinical Studies ◽  
Nonoperative Management ◽  
Additional Patient ◽  
Future Directions ◽  
Current Article ◽  
Active Research ◽  
Improve Patient ◽  
Potential Use

Intra-articular hyaluronic acid viscosupplementation is gaining popularity as a treatment option in the nonoperative management of patients with osteoarthritis. Recent clinical studies have demonstrated that the anti-inflammatory, anabolic, and chondroprotective actions of hyaluronic acid reduce pain and improve patient function. With evidence mounting in support of the efficacy of this treatment modality for patients with osteoarthritis, its potential use in additional patient populations and for other pathologies affecting the knee is being investigated. The current article reviews the use of intra-articular hyaluronic acid viscosupplementation in the management of knee osteoarthritis and presents the potential for expanding its indications for other joints and alternative patient subpopulations. Additionally, future directions for the use of hyaluronic acid and areas of active research are discussed.

scholarly journals Clinical studies in CRS and HIPEC: Trials, tribulations, and future directions-A systematic review

2017 ◽  
Vol 117 (2) ◽  
pp. 245-259 ◽  
Author(s):  
William F. Morano ◽  
Marian Khalili ◽  
Dennis S. Chi ◽  
Wilbur B. Bowne ◽  
Jesus Esquivel
Keyword(s):  
Systematic Review ◽  
Clinical Studies ◽  
Future Directions ◽  
Crs And Hipec

scholarly journals Ablation plus Transarterial Embolic Therapy for Hepatocellular Carcinoma Larger than 3 cm: Science, Evidence, and Future Directions

2019 ◽  
Vol 36 (04) ◽  
pp. 303-309 ◽  
Author(s):  
Andrew R. Lewis ◽  
Carlos A. Padula ◽  
J Mark McKinney ◽  
Beau B. Toskich
Keyword(s):  
Hepatocellular Carcinoma ◽  
Combination Therapy ◽  
Clinical Studies ◽  
Thermal Ablation ◽  
Early Stage ◽  
Future Directions ◽  
Improved Outcomes ◽  
Definitive Therapy ◽  
Science Evidence

AbstractThermal ablation is widely regarded as definitive therapy for early-stage hepatocellular carcinoma, but its efficacy decreases in tumors greater than 3 cm. Extensive clinical studies have supported improved outcomes provided through combining transarterial embolic therapy with ablation in the treatment of larger tumors. This article will provide a survey of the science and data for combination therapy in both thermal and nonthermal ablation modalities, as well as describe emerging applications.

scholarly journals Updating Perspectives on Meta-Analyses in the Field of Radiation Oncology

Medicina ◽  
2021 ◽  
Vol 57 (2) ◽  
pp. 117
Author(s):  
In-Soo Shin ◽  
Chai Hong Rim
Keyword(s):  
Rare Diseases ◽  
Radiation Oncology ◽  
Clinical Studies ◽  
Observational Studies ◽  
Risk Of Bias ◽  
Controlled Trials ◽  
Future Directions ◽  
Clinical Evaluations ◽  
Randomized Controlled ◽  
Meta Analyses

Meta-analyses have been conventionally performed to extract the firmest conclusions from randomized controlled trials while minimizing the risk of bias. However, the field of oncology does not always allow for collecting the best evidence. Radiation oncology is a discipline where intractable or rare diseases are commonly encountered; hence, more practical data suitable for detailed clinical evaluations are needed. This review discusses new viewpoints regarding meta-analyses by pointing out heterogeneities among clinical studies and issues related to analyzing observational studies, thus clarifying the practical utility of meta-analyses in radiation oncology. Limitations of previous systematic reviews or meta-analyses are also assessed to suggest future directions.

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