Immunomodulation by Genetic Modification Using Lentiviral Vectors

2012 ◽  
pp. 51-67
Author(s):  
Frederick Arce ◽  
Karine Breckpot ◽  
Grazyna Kochan ◽  
David Escors
Keyword(s):  
Genetic Modification ◽  
Lentiviral Vectors

scholarly journals Pseudotyping Lentiviral Vectors: When the Clothes Make the Virus

Viruses ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1311 ◽  
Author(s):  
Alexis Duvergé ◽  
Matteo Negroni
Keyword(s):  
Gene Therapy ◽  
Genetic Modification ◽  
Viral Vectors ◽  
Molecular Level ◽  
Lentiviral Vectors ◽  
Human Cells ◽  
Surface Proteins ◽  
Holy Grail ◽  
Viral Therapy

Delivering transgenes to human cells through transduction with viral vectors constitutes one of the most encouraging approaches in gene therapy. Lentivirus-derived vectors are among the most promising vectors for these approaches. When the genetic modification of the cell must be performed in vivo, efficient specific transduction of the cell targets of the therapy in the absence of off-targeting constitutes the Holy Grail of gene therapy. For viral therapy, this is largely determined by the characteristics of the surface proteins carried by the vector. In this regard, an important property of lentiviral vectors is the possibility of being pseudotyped by envelopes of other viruses, widening the panel of proteins with which they can be armed. Here, we discuss how this is achieved at the molecular level and what the properties and the potentialities of the different envelope proteins that can be used for pseudotyping these vectors are.

Genetic Modification of Human Trabecular Meshwork with Lentiviral Vectors

2001 ◽  
Vol 12 (17) ◽  
pp. 2109-2119 ◽  
Author(s):  
Nils Loewen ◽  
Michael P. Fautsch ◽  
Mary Peretz ◽  
Cindy K. Bahler ◽  
J. Douglas Cameron ◽  
...  
Keyword(s):  
Genetic Modification ◽  
Trabecular Meshwork ◽  
Lentiviral Vectors

Stable Genetic Modification of Mesenchymal Stromal Cells Using Lentiviral Vectors

2019 ◽  
pp. 267-280 ◽  
Author(s):  
Francisco Martín ◽  
María Tristán-Manzano ◽  
Noelia Maldonado-Pérez ◽  
Sabina Sánchez-Hernández ◽  
Karim Benabdellah ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Genetic Modification ◽  
Stromal Cells ◽  
Lentiviral Vectors

Efficient Genetic Modification of Cynomolgus Monkey Embryonic Stem Cells with Lentiviral Vectors

2010 ◽  
Vol 19 (9) ◽  
pp. 1181-1193 ◽  
Author(s):  
Weiqiang Li ◽  
Chang Liu ◽  
Jie Qin ◽  
Li Zhang ◽  
Rui Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Genetic Modification ◽  
Cynomolgus Monkey ◽  
Embryonic Stem ◽  
Lentiviral Vectors

scholarly journals 375. A Glaucoma Gene Therapy Model: Eighteen Cat Study Revealing Long-Term Targeted Genetic Modification of the Anterior Chamber by Lentiviral Vectors

2006 ◽  
Vol 13 ◽  
pp. S142-S143
Author(s):  
Pranay D. Khare ◽  
Nils Loewen ◽  
Roman Barraza ◽  
Michael Fautsch ◽  
Douglas Johnson ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Anterior Chamber ◽  
Genetic Modification ◽  
Lentiviral Vectors ◽  
Therapy Model
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