Mitochondria, free radicals, neurodegeneration and aging

1995 ◽  
pp. 159-169 ◽  
Author(s):  
A. H. V. Schapira
Keyword(s):  
Free Radicals

STRESS PADA LANSIA MENJADI FAKTOR PENYEBAB DAN AKIBAT TERJADINYA PENYAKIT

2015 ◽  
Vol 6 (2) ◽  
Author(s):  
Nur Hidaayah
Keyword(s):  
Drinking Water ◽  
Free Radicals ◽  
The Elderly ◽  
The State ◽  
Young Age ◽  
Fresh Fruit ◽  
Stress Conditions ◽  
Harmful Substances ◽  
Available Resources

Stress conditions in the elderly means an imbalance condition of biological, psychological, and social are closely related to the response to the threats and dangers faced by the elderly. Pressure or interference that is not fun is usually created when the elderly see a mismatch between the state and the 3 systems available resources. Maintenance actions that need to be done there are 2 types, namely : prevention of exposure to a stressor (precipitation factor) and serious treatment of the imbalance condition/ illness (precipitation factor). Prevention includes: sports, hobbies, friendship, avoid eating foods high in free radicals and harmful substances, sex and setting arrangements adequate rest. Habits of the above if done at a young age to avoid exposure to stress in the elderly. Treatment of the imbalance condition / illness, include : drinking water, meditation, eating fresh fruit, and adequate rest.

Magnetic properties of free radicals

1988 ◽  
Vol 155 (5) ◽  
pp. 180-180
Author(s):  
Anatolii L. Buchachenko
Keyword(s):  
Magnetic Properties ◽  
Free Radicals

THE X2BO and X2BS (X = HYDROGEN OR HALOGEN) FREE RADICALS

2014 ◽  
Author(s):  
Dennis Clouthier ◽  
Phillip Sheridan ◽  
Bing Jin ◽  
Robert Grimminger
Keyword(s):  
Free Radicals ◽  
Halogen Free

Astrocytes in health and disease

2007 ◽  
Vol 148 (15) ◽  
pp. 697-702 ◽  
Author(s):  
Marianna Murányi ◽  
Zsombor Lacza
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Free Radicals ◽  
Molecular Mechanisms ◽  
Neuronal Dysfunction ◽  
Supporting Cells ◽  
Neuronal Synapses ◽  
Health And Disease ◽  
Novel Targets ◽  
Therapeutic Tools

It is now known that astrocytes are not merely supporting cells but they also play an important role in neuronal funcions. Astrocytes tightly ensheat neuronal synapses and regulate the excitation of neurons by uptaking neurotransmitters; reglulate the cerebral blood flow, cerebral fluid volume and extracellular concentrations of ions. They also supply fuel in the form of lactate and provide free radical scavangers such as glutathione for active neurons. These facts indicate that impaired function of astrocytes may lead to neuronal dysfunction. After brain injury (stroke, trauma or tumors) astrocytes are swollen and release active molecules such as glutamate or free radicals resulting in neuronal dysfunction. Thus, investigation of the molecular mechanisms of astrocyte function may reveal novel targets for the development of therapeutic tools in neuronal diseases.

From free radicals to science of nutrition

2009 ◽  
Vol 150 (2) ◽  
pp. 53-63 ◽  
Author(s):  
Anna Blázovics
Keyword(s):  
Free Radicals

A szabadgyök-kutatás évtizedei alatt egyre közelebb kerültünk ahhoz a felismeréshez, hogy a szervezet szabad gyök–antioxidáns egyensúlyát alapvetően a genetikai háttér és a környezet határozza meg. A Janus-arcú oxigén-szabadgyökök a szignáltranszdukciós utak szekunder hírvivői és egyben a sejtek citotoxikus ágensei is. A szignáltranszdukciós fehérjék mérsékelt oxidációs hatásokra és fémionokra történő aktivációja még nem eléggé ismert. A szignáltranszdukció aktivátorai és inhibitorai közötti molekuláris mechanizmusok finoman kontrolláltak. A sejtek antioxidáns–prooxidáns egyensúlya visszavezethető a szabad szulfhidrilcsoportok és a diszulfidhidak koncentrációviszonyára. Az esszenciális és toxikus fémionok, valamint a szelén egyaránt szerepet játszanak a redox-homeosztázisban. Az egészséges szövetek bővelkednek antioxidánsokban, ezáltal biztosítják a szervezet szabad gyökökkel szembeni védelmét. A táplálékkal felvett antioxidáns vegyületek, mint például az A-, C-, E-vitaminok, polifenolok, antocianinok, flavonoidok, izotiocianátok és más bioaktív molekulák eredeti molekulaformájukban és derivátumaikban is képesek befolyásolni a redoxifolyamatokat. Napjaink molekuláris biológai kutatásainak eredményeképpen egyre több, táplálékkal felvehető vegyületről, illetve azok metabolitjairól bizonyosodik be, hogy génszinten is kifejtik hatásukat.

Simple Modification Measurement of Photodegradability of Polymers by using Photo-induced Chemiluminescence Technique

2013 ◽  
Vol 10 (2) ◽  
pp. 51
Author(s):  
Siti Farhana Zakaria ◽  
Keith R Millington
Keyword(s):  
Free Radicals ◽  
Organic Materials ◽  
Oxidative Degradation ◽  
Working Life ◽  
Bimolecular Reaction ◽  
Synthetic Polymers ◽  
Accelerated Weathering ◽  
Simple Modification ◽  
Uv Absorbers ◽  
Irradiation Period

Polymers and organic materials that are exposed to sunlight undergo photooxidation, which leads to deterioration of their physical properties. To allow adequate performance under outdoor conditions, synthetic polymers require additives such as antioxidants and UV absorbers. A major problem with optimising polymer formulations to maximise their working life span is that accelerated weathering tests are empirical. The conditions differ significantly from real weathering situations, and samples require lengthy irradiation period. Degradation may not be apparent in the early stages of exposure, although this is when products such as hydroperoxides are formed which later cause acceleration of oxidation. A simple way of quantifying the number of free radicals presents in organic materials following exposure to light or heat is by measuring chemiluminescence (CL) emission. Most polymers emit CL when they undergo oxidative degradation, and it originates from the bimolecular reaction of macroperoxy radicals which creates an excited carbonyl.

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