Need for a Continuum Biochemomechanical Theory of Soft Tissue and Cellular Growth and Remodeling

2009 ◽  
pp. 1-82 ◽  
Author(s):  
J. D. Humphrey
Keyword(s):  
Soft Tissue ◽  
Cellular Growth ◽  
Growth And Remodeling

scholarly journals Critical roles of time-scales in soft tissue growth and remodeling

2018 ◽  
Vol 2 (2) ◽  
pp. 026108 ◽  
Author(s):  
Marcos Latorre ◽  
Jay D. Humphrey
Keyword(s):  
Soft Tissue ◽  
Time Scales ◽  
Tissue Growth ◽  
Growth And Remodeling

scholarly journals Fast, Rate-Independent, Finite Element Implementation of a 3D Constrained Mixture Model of Soft Tissue Growth and Remodeling

2020 ◽  
Author(s):  
Marcos Latorre ◽  
Jay D. Humphrey
Keyword(s):  
Finite Element ◽  
Soft Tissue ◽  
Mixture Models ◽  
Tissue Growth ◽  
Aortic Aneurysms ◽  
Growth And Remodeling ◽  
Adaptive Process ◽  
Finite Element Implementation ◽  
Constrained Mixture ◽  
Diseased Segment

AbstractConstrained mixture models of soft tissue growth and remodeling can simulate many evolving conditions in health as well as in disease and its treatment, but they can be computationally expensive. In this paper, we derive a new fast, robust finite element implementation based on a concept of mechanobiological equilibrium that yields fully resolved solutions and allows computation of quasi-equilibrated evolutions when imposed perturbations are slow relative to the adaptive process. We demonstrate quadratic convergence and verify the model via comparisons with semi-analytical solutions for arterial mechanics. We further examine the enlargement of aortic aneurysms for which we identify new mechanobiological insights into factors that affect the nearby non-aneurysmal segment as it responds to the changing mechanics within the diseased segment. Because this new 3D approach can be implemented within many existing finite element solvers, constrained mixture models of growth and remodeling can now be used more widely.

Magnetoelastic Materials as Novel Bioactive Coatings for Bone Anchored Prostheses

2009 ◽  
Author(s):  
Eli Vlaisavljevich ◽  
Logan P. Janka ◽  
Keat G. Ong ◽  
Rupak M. Rajachar
Keyword(s):  
Soft Tissue ◽  
Mechanical Stability ◽  
Cellular Growth ◽  
Bioactive Coatings ◽  
Extracellular Matrix Components ◽  
Anchoring System ◽  
Magnetoelastic Materials ◽  
External Connection ◽  
The Stability ◽  
A Site

Enhanced fibroblast activity at the implant-soft tissue interface is a key concern to the long-term success of many implanted biomaterials. Uncontrolled fibrosis has been shown to dramatically decrease the stability, function, and lifespan of biomedical implants. Fibrosis, defined as the overgrowth of various tissues about the implant, is caused by the excess synthesis of extracellular matrix components, primarily collagen, and often leads to walling off and hardening (calcification) of tissues at the biomaterial interface (1). Fibrosis is currently a major deterrent to stable bone anchored prostheses. These bone anchored mounting systems are designed to surgically attach a prosthesis mounting post directly into a patient’s bone. The attached post protrudes from the bone through the overlying soft tissue of the amputated limb providing an external connection point for the prosthetic. Although the bone anchoring system dramatically improves prosthetic limb mechanical stability, uncontrolled fibrosis at the soft tissue-mounting post interface is a significant problem (2). The fibrosis caused from aberrant cellular growth leads to the formation of irregular skin folds that prevent proper sealing to the bone anchoring post and also serves as a site for opportunistic infection and failure of the prosthetic system.

scholarly journals Characterization and Modeling of Growth and Remodeling in Tendon and Soft Tissue Constructs

2006 ◽  
pp. 63-75
Author(s):  
E. M. Arruda ◽  
S. C. Calve ◽  
K. Garikipati ◽  
K. Grosh ◽  
H. Narayanan
Keyword(s):  
Soft Tissue ◽  
Growth And Remodeling ◽  
Tissue Constructs

A Constitutive Model for Soft Tissue and its Application to a Boundary Value Problem

2013 ◽  
Author(s):  
P. Mythravaruni ◽  
Parag Ravindran
Keyword(s):  
Soft Tissue ◽  
Mixture Theory ◽  
Axial Loading ◽  
Tissue Growth ◽  
Theory Approach ◽  
Growth And Remodeling ◽  
Constrained Mixture ◽  
Set Up ◽  
And Function ◽  
Turn Over

Mechanical loading induces changes in the structure and function of soft tissue. Growth and remodeling results from the production and removal of constituents. We consider a tissue constituted of elastin and collagen. The collagen turns over at a much higher rate than elastin. In this work we propose a two-constituent, constrained mixture model for this soft tissue. One constituent is modeled as a viscoelastic material and the other as an elastic material. It is assumed that the collagen turns over depending on the stress applied and the elastin does not turn over. The standard mixture theory approach is followed and the balance equations are set-up. The model is studied in simple uni-axial loading to test its efficacy.

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