Towards Spatial Correspondence between Specimen and In-vivo Breast Imaging

2014 ◽  
pp. 674-680 ◽  
Author(s):  
Thomy Mertzanidou ◽  
John Hipwell ◽  
Mehmet Dalmis ◽  
Bram Platel ◽  
Jeroen van der Laak ◽  
...  
Keyword(s):  
Breast Imaging ◽  
Spatial Correspondence

scholarly journals Handheld diffuse optical breast scanner probe for cross-sectional imaging of breast tissue

2019 ◽  
Vol 12 (02) ◽  
pp. 1950008 ◽  
Author(s):  
Majid Shokoufi ◽  
Farid Golnaraghi
Keyword(s):  
Breast Cancer ◽  
Breast Imaging ◽  
Breast Tissue ◽  
Reconstruction Algorithm ◽  
Breast Cancer Diagnosis ◽  
Array Detector ◽  
Light Sources ◽  
Compact Structure ◽  
Cross Sectional

Diffuse optical spectroscopy is a relatively new, noninvasive and nonionizing technique for breast cancer diagnosis. In the present study, we have introduced a novel handheld diffuse optical breast scan (DOB-Scan) probe to measure optical properties of the breast in vivo and create functional and compositional images of the tissue. In addition, the probe gives more information about breast tissue’s constituents, which helps distinguish a healthy and cancerous tissue. Two symmetrical light sources, each including four different wavelengths, are used to illuminate the breast tissue. A high-resolution linear array detector measures the intensity of the back-scattered photons at different radial destinations from the illumination sources on the surface of the breast tissue, and a unique image reconstruction algorithm is used to create four cross-sectional images for four different wavelengths. Different from fiber optic-based illumination techniques, the proposed method in this paper integrates multi-wavelength light-emitting diodes to act as pencil beam sources into a scattering medium like breast tissue. This unique design and its compact structure reduce the complexity, size and cost of a potential probe. Although the introduced technique miniaturizes the probe, this study points to the reliability of this technique in the phantom study and clinical breast imaging. We have received ethical approval to test the DOB-Scan probe on patients and we are currently testing the DOB-Scan probe on subjects who are diagnosed with breast cancer.

Breast Imaging with 3D Ultrasound Computer Tomography: Results of a First In-vivo Study in Comparison to MRI Images

2014 ◽  
pp. 72-79 ◽  
Author(s):  
Torsten Hopp ◽  
Lukas Šroba ◽  
Michael Zapf ◽  
Robin Dapp ◽  
Ernst Kretzek ◽  
...  
Keyword(s):  
Computer Tomography ◽  
Breast Imaging ◽  
3D Ultrasound ◽  
In Vivo Study

scholarly journals Biomedical photoacoustic imaging

2011 ◽  
Vol 1 (4) ◽  
pp. 602-631 ◽  
Author(s):  
Paul Beard
Keyword(s):  
Optical Imaging ◽  
Ultrasound Imaging ◽  
Spatial Resolution ◽  
Breast Imaging ◽  
Clinical Medicine ◽  
Blood Oxygenation ◽  
Whole Body ◽  
Practical Implementation ◽  
Wide Range

Photoacoustic (PA) imaging, also called optoacoustic imaging, is a new biomedical imaging modality based on the use of laser-generated ultrasound that has emerged over the last decade. It is a hybrid modality, combining the high-contrast and spectroscopic-based specificity of optical imaging with the high spatial resolution of ultrasound imaging. In essence, a PA image can be regarded as an ultrasound image in which the contrast depends not on the mechanical and elastic properties of the tissue, but its optical properties, specifically optical absorption. As a consequence, it offers greater specificity than conventional ultrasound imaging with the ability to detect haemoglobin, lipids, water and other light-absorbing chomophores, but with greater penetration depth than purely optical imaging modalities that rely on ballistic photons. As well as visualizing anatomical structures such as the microvasculature, it can also provide functional information in the form of blood oxygenation, blood flow and temperature. All of this can be achieved over a wide range of length scales from micrometres to centimetres with scalable spatial resolution. These attributes lend PA imaging to a wide variety of applications in clinical medicine, preclinical research and basic biology for studying cancer, cardiovascular disease, abnormalities of the microcirculation and other conditions. With the emergence of a variety of truly compelling in vivo images obtained by a number of groups around the world in the last 2–3 years, the technique has come of age and the promise of PA imaging is now beginning to be realized. Recent highlights include the demonstration of whole-body small-animal imaging, the first demonstrations of molecular imaging, the introduction of new microscopy modes and the first steps towards clinical breast imaging being taken as well as a myriad of in vivo preclinical imaging studies. In this article, the underlying physical principles of the technique, its practical implementation, and a range of clinical and preclinical applications are reviewed.

Potential Applications of Vibro-acoustography in Breast Imaging

2005 ◽  
Vol 4 (2) ◽  
pp. 151-157 ◽  
Author(s):  
Azra Alizad ◽  
Dana H. Whaley ◽  
James F. Greenleaf ◽  
Mostafa Fatemi
Keyword(s):  
Soft Tissue ◽  
Medical Imaging ◽  
Breast Imaging ◽  
Low Frequency ◽  
Radiation Force ◽  
Tissue Imaging ◽  
Future Developments ◽  
Potential Applications ◽  
Potential Impact

Vibro-acoustography has gained interest in the recent years as a new modality for medical imaging. This method is based on low-frequency vibrations induced in the object by the radiation force of ultrasound. This paper focuses on potential applications of vibro-acoustography in breast imaging, including detection of microcalcifications, detection of arterial calcifications, and soft tissue imaging. In addition, we will briefly discuss our recent results of in vivo breast vibro-acoustography. Future developments and potential impact of vibro-acoustography in breast imaging are also discussed.

scholarly journals Second-Generation Dual Scan Mammoscope With Photoacoustic, Ultrasound, and Elastographic Imaging Capabilities

2021 ◽  
Vol 11 ◽  
Author(s):  
Emily Zheng ◽  
Huijuan Zhang ◽  
Soumya Goswami ◽  
Irteza Enan Kabir ◽  
Marvin M. Doyley ◽  
...  
Keyword(s):  
Breast Imaging ◽  
Breast Tissue ◽  
Second Generation ◽  
Mechanical Stability ◽  
Three Dimensional ◽  
Ultrasound Elastography ◽  
Field Of View ◽  
System Stability ◽  
New System

We recently developed the photoacoustic dual-scan mammoscope (DSM), a system that images the patient in standing pose analog to X-ray mammography. The system simultaneously acquires three-dimensional photoacoustic and ultrasound (US) images of the mildly compressed breast. Here, we describe a second-generation DSM (DSM-2) system that offers a larger field of view, better system stability, higher ultrasound imaging quality, and the ability to quantify tissue mechanical properties. In the new system, we doubled the field of view through laterally shifted round-trip scanning. This new design allows coverage of the entire breast tissue. We also adapted precisely machined holders for the transducer-fiber bundle sets. The new holder increased the mechanical stability and facilitated image registration from the top and bottom scanners. The quality of the US image is improved by increasing the firing voltage and the number of firing angles. Finally, we incorporated quasi-static ultrasound elastography to allow comprehensive characterization of breast tissue. The performance of the new system was demonstrated through in vivo human imaging experiments. The experimental results confirmed the capability of the DSM-2 system as a powerful tool for breast imaging.

Enhanced Phase-Contrast Diffuse Optical Tomography for in vivo Breast Imaging

2010 ◽  
Author(s):  
Ruixin Jiang ◽  
Xiaoping Liang ◽  
Qizhi Zhang ◽  
Stephen Grobmyer ◽  
Laurie L. Fajardo ◽  
...  
Keyword(s):  
Breast Imaging ◽  
Phase Contrast ◽  
Optical Tomography ◽  
Diffuse Optical Tomography

Ultrasonographic Breast Imaging using Full Angle Spatial Compounding (FASC): In-vivo evaluations

2008 ◽  
Vol 29 (S 03) ◽  
Author(s):  
M Hollenhorst ◽  
C Hansen ◽  
N Hüttebräuker ◽  
L Heuser ◽  
H Ermert ◽  
...  
Keyword(s):  
Breast Imaging ◽  
Spatial Compounding
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