Predicting Biological Activity of 2,4,6-trisubstituted 1,3,5-triazines Using Random Forest

2014 ◽  
pp. 101-110
Author(s):  
Ahmed H. Abu El-Atta ◽  
M. I. Moussa ◽  
Aboul Ella Hassanien
Keyword(s):  
Biological Activity ◽  
Random Forest

scholarly journals A18 DIETARY PREDICTORS OF BIOLOGICAL ACTIVITY IN CROHN’S DISEASE: A RETROSPECTIVE COHORT STUDY

2021 ◽  
Vol 4 (Supplement_1) ◽  
pp. 23-24
Author(s):  
E Chiu ◽  
Z Zhang ◽  
L Taylor ◽  
S Kaur ◽  
S Ghosh ◽  
...  
Keyword(s):  
Biological Activity ◽  
Cohort Study ◽  
Crohn’S Disease ◽  
Random Forest ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Food Groups

Abstract Background Patients with Crohn’s disease (CD) often seek advice on optimizing their diet to reduce gut inflammation. The relationship between dietary patterns, major food groups and individual nutrients, with disease activity in Crohn’s disease (CD) is incompletely understood and warrants further investigation. Aims 1.To determine whether a diversified (DD) or nondiversified (NDD) dietary pattern is related to biological activity in CD (BACD) in long-term follow up. 2.To determine if specific foods or nutrients are associated with increased BACD. Methods In this retrospective cohort study, forty-six CD patients (52% male) in remission completed 3-day food records between 2015–2017 for a 3-month intervention study and were classified as DD or NDD. Remission was defined by a Harvey Bradshaw Index <5 and no endoscopic ulcerations within 6 months of baseline data collection. Patients were classified as NDD if dietary fibre was ≤15 g/day or total fruit/vegetable servings ≤3/week, and if they consumed ≥3 servings/week of red and processed meat. Patients were otherwise defined as DD. A retrospective chart review captured BACD data. BACD was defined as one of either fecal calprotectin (FCP) ≥250 ug/g, hospitalization for CD flare, bowel resection for active CD, biologic dose escalation/switch due to non-response (not therapeutic drug monitoring), corticosteroid use, endoscopic evidence of apthous or large ulcers, or active disease on contrast enhanced ultrasound or magnetic resonance enterography. Machine learning methods with random forest prediction models assessed if diet composition was associated with BACD followed by univariate Mann-Whitney tests to compare differences between high and low disease activity. Results Sixteen patients (35%) had BACD during the mean 42 month follow up (31–54 months,SD ± 6.6). See Table 1 for additional demographics. Based on the random forest prediction model, both vitamins and minerals, food groups and Mediterranean diet cut-points could predict disease activity responses (ROC-AUC = 0.68 and 0.75, respectively). For these models, baseline intake of vitamins E, D, B1, and C and leafy greens, and fruit intake were the most important predictors of BACD. For the univariate analysis, the high disease group had lower intakes of fiber, vitamin E, and C (p = 0.047, 0.066, and 0.09, respectively). A higher proportion of patients consumed a NDD with BACD compared to those without BACD (50% vs. 23.3%, p=0.07). Conclusions To our knowledge, this is the first study to assess if dietary patterns, foods and nutrients are able to predict disease activity over a mean 42 month follow up. Further research into the dietary determinants of BACD in CD is warranted. With higher baseline FCP observed in the BACD, multivariate analyses to assess the independent effect of diet to predict BACD is required. Funding Agencies Litwin IBD Pioneers Foundation, Alberta’s Collaboration of Excellence for Nutrition in Digestive Diseases (Ascend)

Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

1973 ◽  
Vol 31 ◽  
pp. 378-379
Author(s):  
G. Kasnic ◽  
S. E. Stewart ◽  
C. Urbanski
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Human Breast Cancer ◽  
Osteogenic Sarcoma ◽  
Human Tumor ◽  
Structural Similarity ◽  
Cell Tumor ◽  
Human Breast ◽  
Human Tumor Cell ◽  
Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

Effects of Vincristine on Endothelial Microtubules in the Spinal Cord

1976 ◽  
Vol 34 ◽  
pp. 58-59
Author(s):  
John L. Beggs ◽  
John D. Waggener ◽  
Wanda Miller
Keyword(s):  
Spinal Cord ◽  
Biological Activity ◽  
Horseradish Peroxidase ◽  
Transport Mechanism ◽  
Vasogenic Edema ◽  
Vesicular Transport ◽  
Close Proximity

Microtubules (MT) are versatile organelles participating in a wide variety of biological activity. MT involvement in the movement and transport of cytoplasmic components has been well documented. In the course of our study on trauma-induced vasogenic edema in the spinal cord we have concluded that endothelial vesicles contribute to the edema process. Using horseradish peroxidase as a vascular tracer, labeled endothelial vesicles were present in all situations expected if a vesicular transport mechanism was in operation. Frequently,labeled vesicles coalesced to form channels that appeared to traverse the endothelium. The presence of MT in close proximity to labeled vesicles sugg ested that MT may play a role in vesicular activity.

Isothiazol-3(2 H )-ones, Part I: Synthesis, Reactions and Biological Activity

2002 ◽  
Vol 23 (1) ◽  
pp. 79-121 ◽  
Author(s):  
Kathleen Taubert ◽  
Susanne Kraus ◽  
Bärbel Schulze
Keyword(s):  
Biological Activity ◽  
Synthesis Reactions

Evaluation of biological activity of lignans extracted from tree knots

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
E Spilioti ◽  
B Holmbom ◽  
P Moutsatsou
Keyword(s):  
Biological Activity

Phytochemical analysis and biological activity of the flavonoids from the Mongolian medicinal plant Dianthus versicolor Fisch.

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
A Obmann ◽  
A Presser ◽  
C Kletter ◽  
T Thalhammer ◽  
S Glasl
Keyword(s):  
Biological Activity ◽  
Medicinal Plant ◽  
Phytochemical Analysis

Investigation of volatiles, lipoidal matter and biological activity of the aerial parts of Dichrostachys cinerea L.

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
AH Abou Zeid ◽  
MS Hifnawy ◽  
AA Sleem ◽  
RS Mohammed
Keyword(s):  
Biological Activity ◽  
Dichrostachys Cinerea ◽  
Aerial Parts

Taxonomy, occurrence, phytochemical evaluation and biological activity of selected basidiomycetes from Yemen

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
M Al-Fatimi ◽  
H Kreisel ◽  
U Lindequist
Keyword(s):  
Biological Activity

Biological activity of Alpinia galanga root tubers

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
HRW Dharmaratne ◽  
BL Tekwani ◽  
M Jacob ◽  
NPD Nanayakkara
Keyword(s):  
Biological Activity ◽  
Alpinia Galanga

Synthesis and biological activity of some C(9)-hydroxymethyl-5,11-dimethylellipticine derivatives

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
N Mexia ◽  
S Michel ◽  
VPC Rocha ◽  
CS Meira ◽  
TS Macedo ◽  
...  
Keyword(s):  
Biological Activity
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