RNA Methylation in the Control of Stem Cell Activity and Epidermal Differentiation

2018 ◽  
pp. 215-229
Author(s):  
Abdulrahim A. Sajini ◽  
Michaela Frye
Keyword(s):  
Stem Cell ◽  
Cell Activity ◽  
Epidermal Differentiation ◽  
Rna Methylation ◽  
Stem Cell Activity

scholarly journals Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer.

2021 ◽  
Author(s):  
Katie Cockburn ◽  
Karl Annusver ◽  
Smirthy Ganesan ◽  
Kailin R Mesa ◽  
Kyogo Kawaguchi ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cell ◽  
Cell Layer ◽  
Cell Activity ◽  
Epidermal Differentiation ◽  
Cell Cycle Exit ◽  
High Turnover ◽  
Daughter Cells ◽  
Stem Cell Activity ◽  
Transcriptional Changes

High turnover tissues continually lose specialized cells that are replaced by stem cell activity. In the adult mammalian epidermis, it is unclear how molecularly heterogenous stem/progenitor cell populations fit into the complete trajectory of epidermal differentiation. We show that differentiation, from commitment to exit from the stem cell layer, is a multi-day process wherein cells transit through a continuum of transcriptional changes. Differentiation-committed cells remain capable of dividing to produce daughter cells fated to further differentiate, demonstrating that differentiation is uncoupled from cell cycle exit. These cell divisions are not required as part of an obligate transit amplifying program but instead protect density in the stem cell layer. Thus, instead of distinct contributions from multiple progenitors, a continuous gradual differentiation process fuels homeostatic epidermal turnover.

scholarly journals Hair-follicle mesenchymal stem-cell activity during homeostasis and wound healing

2021 ◽  
Author(s):  
Emil Aamar ◽  
Efrat Avigad Laron ◽  
Wisal Asaad ◽  
Sarina Harshuk-Shabso ◽  
David Enshell-Seijffers
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Hair Follicle ◽  
Cell Activity ◽  
Stem Cell Activity

scholarly journals 814 – Helicobacter Pylori Induces Aberrant Lrig1 Stem Cell Activity Within the Stomach in a Cag Type Iv Secretion System-Dependent Manner

2019 ◽  
Vol 156 (6) ◽  
pp. S-171-S-172 ◽  
Author(s):  
Lydia Wroblewski ◽  
Eunyoung Choi ◽  
Christine Petersen ◽  
Alberto Delgado ◽  
M. Blanca Piazuelo ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Stem Cell ◽  
Cell Activity ◽  
Secretion System ◽  
Type Iv Secretion ◽  
Type Iv Secretion System ◽  
Dependent Manner ◽  
Type Iv ◽  
Stem Cell Activity

Clinical-Scale Cultures of Cord Blood CD34+Cells to Amplify Committed Progenitors and Maintain Stem Cell Activity

2011 ◽  
Vol 20 (9) ◽  
pp. 1453-1464 ◽  
Author(s):  
Zoran Ivanovic ◽  
Pascale Duchez ◽  
Jean Chevaleyre ◽  
Marija Vlaski ◽  
Xavier Lafarge ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cord Blood ◽  
Cell Activity ◽  
Clinical Scale ◽  
Cd34 Cells ◽  
Stem Cell Activity ◽  
Cord Blood Cd34

The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells

2015 ◽  
Vol 357 (1) ◽  
pp. 206-218 ◽  
Author(s):  
Saeb Aliwaini ◽  
Jade Peres ◽  
Wendy L. Kröger ◽  
Angelique Blanckenberg ◽  
Jo de la Mare ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cell Activity ◽  
Anti Cancer ◽  
Stem Cell Activity
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