Tissue Engineering Scaffolds for Bone Repair: General Aspects

2016 ◽  
pp. 269-285 ◽  
Author(s):  
Andrés Díaz Lantada ◽  
Adrián de Blas Romero ◽  
Santiago Valido Moreno ◽  
Diego Curras ◽  
Miguel Téllez ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Repair ◽  
Tissue Engineering Scaffolds ◽  
General Aspects

scholarly journals A Nanofiber Mat With Dual Bioactive Components and a Biomimetic Matrix Structure for Improving Osteogenesis Effect

2021 ◽  
Vol 9 ◽  
Author(s):  
Yadi Han ◽  
Xiaofeng Shen ◽  
Sihao Chen ◽  
Xiuhui Wang ◽  
Juan Du ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Bone Repair ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Bioactive Components ◽  
Tissue Engineering Scaffolds ◽  
Cell Growth And Migration ◽  
Nanofiber Mats

The challenge of effectively regenerating bone tissue through tissue engineering technology is that most tissue engineering scaffolds cannot imitate the three-dimensional structure and function of the natural extracellular matrix. Herein, we have prepared the poly(L-lactic acid)–based dual bioactive component reinforced nanofiber mats which were named as poly(L-lactic acid)/bovine serum albumin/nanohydroxyapatite (PLLA/BSA/nHAp) with dual bioactive components by combining homogeneous blending and electrospinning technology. The results showed that these nanofiber mats had sufficient mechanical properties and a porous structure suitable for cell growth and migration. Furthermore, the results of cell experiments in vitro showed that PLLA/BSA/nHAp composite nanofiber mat could preferably stimulate the proliferation of mouse osteoblastic cells (MC3T3 cells) compared with pure PLLA nanofiber mats. Based on these results, the scaffolds developed in this study are considered to have a great potential to be adhibited as bone repair materials.

Preparation and characterization of alginate/HACC/oyster shell powder biocomposite scaffolds for potential bone tissue engineering applications

RSC Advances ◽  
2016 ◽  
Vol 6 (42) ◽  
pp. 35577-35588 ◽  
Author(s):  
Tai-ying Chen ◽  
Hao-chao Huang ◽  
Jia-lin Cao ◽  
Yan-jiao Xin ◽  
Wen-feng Luo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Repair ◽  
Oyster Shell ◽  
Natural Polymers ◽  
Tissue Engineering Scaffolds ◽  
Repair Materials ◽  
Oyster Shell Powder ◽  
Bone Repair Materials ◽  
Shell Powder

Tissue engineering scaffolds combining biominerals and natural polymers are prospective candidates for bone repair materials.

Effects of HAp and TCP in constructing tissue engineering scaffolds for bone repair

2017 ◽  
Vol 5 (30) ◽  
pp. 6110-6118 ◽  
Author(s):  
Sijia Xu ◽  
Jianheng Liu ◽  
Licheng Zhang ◽  
Fei Yang ◽  
Peifu Tang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Repair ◽  
Tissue Engineering Scaffold ◽  
Long Term Effects ◽  
Tissue Engineering Scaffolds ◽  
Early Repair

TCP possesses superior long-term effects in structuring tissue engineering scaffold for bone repair compared to HAp, though TCP lags behind HAp in the early repair period.

scholarly journals Bone Repair and Regenerative Biomaterials: Towards Recapitulating the Microenvironment

Polymers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1437 ◽  
Author(s):  
Neda Aslankoohi ◽  
Dibakar Mondal ◽  
Amin S. Rizkalla ◽  
Kibret Mequanint
Keyword(s):  
Tissue Engineering ◽  
Hybrid Materials ◽  
Bone Repair ◽  
Calcium Phosphates ◽  
Tissue Engineering Scaffolds ◽  
Scientific Publications ◽  
Native Bone ◽  
Significant Research ◽  
Materials Used ◽  
Minimal Bias

Biomaterials and tissue engineering scaffolds play a central role to repair bone defects. Although ceramic derivatives have been historically used to repair bone, hybrid materials have emerged as viable alternatives. The rationale for hybrid bone biomaterials is to recapitulate the native bone composition to which these materials are intended to replace. In addition to the mechanical and dimensional stability, bone repair scaffolds are needed to provide suitable microenvironments for cells. Therefore, scaffolds serve more than a mere structural template suggesting a need for better and interactive biomaterials. In this review article, we aim to provide a summary of the current materials used in bone tissue engineering. Due to the ever-increasing scientific publications on this topic, this review cannot be exhaustive; however, we attempted to provide readers with the latest advance without being redundant. Furthermore, every attempt is made to ensure that seminal works and significant research findings are included, with minimal bias. After a concise review of crystalline calcium phosphates and non-crystalline bioactive glasses, the remaining sections of the manuscript are focused on organic-inorganic hybrid materials.

Preparation and Characterization of Biodegradable β-TCP-Based Composite Microspheres as Bone Tissue Engineering Scaffolds

2007 ◽  
Vol 336-338 ◽  
pp. 1646-1649 ◽  
Author(s):  
Qing Feng Zan ◽  
Chen Wang ◽  
Li Min Dong ◽  
Rui Liu ◽  
Jie Mo Tian
Keyword(s):  
Tissue Engineering ◽  
Bone Repair ◽  
Three Dimensional ◽  
Tissue Engineering Scaffolds ◽  
Composite Microspheres ◽  
Globular Particle ◽  
Suspended Cultures ◽  
Chitosan Composite

Since a small globular particle was first used as support for three-dimensional (3D) growth of anchorage-dependent cells in suspended cultures, a variety of microspheres as tissue engineering scaffolds have been developed. In this paper, β-TCP and chitosan were selected as the components of microspheres due to their biodegradability and osteogenic properties. The biodegradable β-TCP/chitosan composite microspheres were prepared by a solid-in-water-in-oil (s/w/o) emulsion cross-linking method in this paper. The size distribution, surface morphology, and microstructure of the microspheres were evaluated. Scanning electron microscopy revealed that the size of the microspheres with good spherical morphology was distributed in the range of 50~200μm. In vitro immersion experiments were carried out to evaluate the degradability of the microspheres, and the results demonstrated that the chitosan/β-TCP composite microspheres were potential materials as tissue engineering scaffolds for bone repair.

Influence of a non-biodegradable porous structure on bone repair

RSC Advances ◽  
2016 ◽  
Vol 6 (84) ◽  
pp. 80522-80528 ◽  
Author(s):  
Xiao Lu ◽  
Yingjun Wang ◽  
Fangchun Jin
Keyword(s):  
Tissue Engineering ◽  
Porous Structure ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Repair ◽  
Structural Parameters ◽  
Tissue Engineering Scaffolds

Pore and interconnection size are two key structural parameters for bone tissue engineering scaffolds.

Novel tissue engineering scaffolds as wound dressings loaded with Alkannins/Shikonins as active ingredients

2019 ◽  
Author(s):  
AS Arampatzis ◽  
K Theodoridis ◽  
E Aggelidou ◽  
KN Kontogiannopoulos ◽  
I Tsivintzelis ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Dressings ◽  
Active Ingredients ◽  
Tissue Engineering Scaffolds

HYDROXYAPATITE, ALGINATE, AND CHITOSAN FOR BONE SCAFFOLDS: SPECTROSCOPY STUDY

2016 ◽  
Vol 19 (2) ◽  
pp. 93-100
Author(s):  
Lalita El Milla
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Functional Groups ◽  
Bone Growth ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Tissue Engineering Scaffolds ◽  
Hydroxyapatite Powder ◽  
Materials Used

Scaffolds is three dimensional structure that serves as a framework for bone growth. Natural materials are often used in synthesis of bone tissue engineering scaffolds with respect to compliance with the content of the human body. Among the materials used to make scafffold was hydroxyapatite, alginate and chitosan. Hydroxyapatite powder obtained by mixing phosphoric acid and calcium hydroxide, alginate powders extracted from brown algae and chitosan powder acetylated from crab. The purpose of this study was to examine the functional groups of hydroxyapatite, alginate and chitosan. The method used in this study was laboratory experimental using Fourier Transform Infrared (FTIR) spectroscopy for hydroxyapatite, alginate and chitosan powders. The results indicated the presence of functional groups PO43-, O-H and CO32- in hydroxyapatite. In alginate there were O-H, C=O, COOH and C-O-C functional groups, whereas in chitosan there were O-H, N-H, C=O, C-N, and C-O-C. It was concluded that the third material containing functional groups as found in humans that correspond to the scaffolds material in bone tissue engineering.

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