The Role of 2D/3D/4D Ultrasound in the Prenatal Assessment of Cleft Lip and Palate

2017 ◽  
pp. 43-59 ◽  
Author(s):  
Pilar Martínez-Ten ◽  
Waldo Sepulveda ◽  
Amy E. Wong ◽  
Gabriele Tonni
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
4D Ultrasound

The role of external aetiological factors in dental anomalies in non-syndromic cleft lip and palate patients

2018 ◽  
Vol 20 (2) ◽  
pp. 105-111 ◽  
Author(s):  
M. V. Korolenkova ◽  
N. V. Starikova ◽  
N. V. Udalova
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Dental Anomalies

Dental Findings in Parents of Children with Cleft Lip and Palate

1996 ◽  
Vol 33 (5) ◽  
pp. 436-439 ◽  
Author(s):  
Peter J. Anderson ◽  
Anthony L.H., Moss
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Normal Population ◽  
Permanent Teeth ◽  
Dental Anomalies ◽  
Facial Skeleton ◽  
Missing Teeth ◽  
Congenitally Missing Teeth ◽  
Congenitally Missing

The incidence of dental abnormalities in the cleft lip and palate population has been reported to be much higher than in the normal population. The role of genes in the production of a cleft lip and palate, and dental anomalies is thought to be complex, with autosomal dominant, recessive, and x-linked genes all playing a role. Noncleft parents can carry some of the cleft lip and palate genes, which produce clinically subtle manifestations in their facial skeleton. The purpose of this study was to look for evidence of increased dental anomalies in the non-cleft parents of cleft lip and palate children. The dentitions of the parents of 60 children with different types of cleft lip and palate were examined prospectively to see whether or not they exhibited features found more readily in the cleft lip and palate rather than did the normal population. Their dentitions were studied to record the following dental features: congenitally missing teeth, supernumerary teeth, or morphologic changes of the crowns of the permanent teeth. The number and position of any frenal attachments were also recorded. The results of this study did not show any differences in incidence of dental anomalies from the noncleft population. There was no evidence to support the hypothesis that congenital absence of lateral incisors is a microform of cleft lip and palate. Further, these results also failed to reveal any consistent pattern in the number and position of frenal attachments.

scholarly journals The important role of MDM2, RPL5, and TP53 in mycophenolic acid-induced cleft lip and palate

Medicine ◽  
2021 ◽  
Vol 100 (21) ◽  
pp. e26101
Author(s):  
Yangyang Lin ◽  
Tao Song ◽  
Elsa M. Ronde ◽  
Gang Ma ◽  
Huiqin Cui ◽  
...  
Keyword(s):  
Mycophenolic Acid ◽  
Cleft Lip ◽  
Cleft Lip And Palate

scholarly journals ROLE OF A PEDODONTIST IN CLEFT LIP AND CLEFT PALATE REHABILITATION - AN OVERVIEW

2021 ◽  
Vol 9 (07) ◽  
pp. 882-906
Author(s):  
Payel Basu ◽  
◽  
Rani Somani ◽  
Deepti Jawa ◽  
Shipra Jaidka ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Multidisciplinary Care ◽  
Vital Role ◽  
Pediatric Dentist ◽  
Orofacial Region ◽  
The Right ◽  
Potential Area

Cleft lip and palate is one of the most common congenital anomalies requiring multidisciplinary care. Such anomaly is associated with many problems such as impaired feeding, defective speech, hearing difficulties, malocclusion, dental abnormalities, gross facial deformity as well severe psychological problems. Cleft of the lip and palate is one of the complex conditions that occur at a functionally potential area in the orofacial region and also at such a crucial time that strategic interventions at the right age by the concerned specialists becomes the need of the hour. Pediatric dentist is an integral part of the cleft rehabilitative process right from the neonatal period upto the phase of permanent dentition. Being well versed with a childs growth and development, both physical and mental, a Pedodontist helps in restoring function and esthetics in a cleft child, in a most empathetic way. This article describes the enormous challenges faced by these innocent souls and the vital role played by a Pedodontist, to provide comprehensive cleft care, be it preventive, restorative, or interventional care, in order to achieve the best possible outcome and meaningfully improve their quality of life.

Role of nostril retainers after rhinoseptoplasties in cleft lip and palate patients

2019 ◽  
Vol 48 ◽  
pp. 14-15
Author(s):  
A.L. Ivanov ◽  
V.A. Pavlovich ◽  
E.I. Reshetnyak ◽  
V.A. Gorbonosov ◽  
D.Y. Anashkina
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate

scholarly journals Evaluating the Expression of Candidate Homeobox Genes and Their Role in Local-Site Inflammation in Mucosal Tissue Obtained from Children with Non-Syndromic Cleft Lip and Palate

2021 ◽  
Vol 11 (11) ◽  
pp. 1135
Author(s):  
Nityanand Jain ◽  
Mara Pilmane
Keyword(s):  
Gene Expression ◽  
Protein Expression ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Homeobox Genes ◽  
Craniofacial Development ◽  
Mucosal Tissue ◽  
Local Site ◽  
Gene And Protein Expression

Craniofacial development including palatogenesis is a complex process which requires an orchestrated and spatiotemporal expression of various genes and factors for proper embryogenesis and organogenesis. One such group of genes essential for craniofacial development is the homeobox genes, transcriptional factors that are commonly associated with congenital abnormalities. Amongst these genes, DLX4, HOXB3, and MSX2 have been recently shown to be involved in the etiology of non-syndromic cleft lip and palate. Hence, we investigated the gene and protein expression of these genes in normal and cleft affected mucosal tissue obtained from 22 children, along with analyzing their role in promoting local-site inflammation using NF-κB. Additionally, we investigated the role of PTX3, which plays a critical role in tissue remodeling and wound repair. We found a residual gene and protein expression of DLX4 in cleft mucosa, although no differences in gene expression levels of HOXB3 and MSX2 were noted. However, a significant increase in protein expression for these genes was noted in the cleft mucosa (p < 0.05), indicating increased cellular proliferation. This was coupled with a significant increase in NF-κB protein expression in cleft mucosa (p < 0.05), highlighting the role of these genes in promotion of pro-inflammatory environment. Finally, no differences in gene expression of PTX3 were noted.

Sign in / Sign up

Export Citation Format

Share Document