Spinal Cord Stimulation for Vegetative State and Minimally Conscious State: Changes in Consciousness Level and Motor Function

Author(s):  
Takamitsu Yamamoto ◽  
Mitsuru Watanabe ◽  
Toshiki Obuchi ◽  
Kazutaka Kobayashi ◽  
Hideki Oshima ◽  
...  
2013 ◽  
Vol 80 (3-4) ◽  
pp. S30.e1-S30.e9 ◽  
Author(s):  
Takamitsu Yamamoto ◽  
Yoichi Katayama ◽  
Toshiki Obuchi ◽  
Kazutaka Kobayashi ◽  
Hideki Oshima ◽  
...  

2012 ◽  
Vol 52 (7) ◽  
pp. 475-481 ◽  
Author(s):  
Takamitsu YAMAMOTO ◽  
Yoichi KATAYAMA ◽  
Toshiki OBUCHI ◽  
Kazutaka KOBAYASHI ◽  
Hideki OSHIMA ◽  
...  

Brain Injury ◽  
2020 ◽  
pp. 1-7
Author(s):  
Sarah Elizabeth Patricia Munce ◽  
Fiona Webster ◽  
Jennifer Christian ◽  
Laura E. Gonzalez-Lara ◽  
Adrian M. Owen ◽  
...  

NeuroSci ◽  
2021 ◽  
Vol 2 (3) ◽  
pp. 254-265
Author(s):  
Jihad Aburas ◽  
Areej Aziz ◽  
Maryam Butt ◽  
Angela Leschinsky ◽  
Marsha L. Pierce

According to the Centers for Disease Control and Prevention (CDC), traumatic brain injury (TBI) is the leading cause of loss of consciousness, long-term disability, and death in children and young adults (age 1 to 44). Currently, there are no United States Food and Drug Administration (FDA) approved pharmacological treatments for post-TBI regeneration and recovery, particularly related to permanent disability and level of consciousness. In some cases, long-term disorders of consciousness (DoC) exist, including the vegetative state/unresponsive wakefulness syndrome (VS/UWS) characterized by the exhibition of reflexive behaviors only or a minimally conscious state (MCS) with few purposeful movements and reflexive behaviors. Electroceuticals, including non-invasive brain stimulation (NIBS), vagus nerve stimulation (VNS), and deep brain stimulation (DBS) have proved efficacious in some patients with TBI and DoC. In this review, we examine how electroceuticals have improved our understanding of the neuroanatomy of consciousness. However, the level of improvements in general arousal or basic bodily and visual pursuit that constitute clinically meaningful recovery on the Coma Recovery Scale-Revised (CRS-R) remain undefined. Nevertheless, these advancements demonstrate the importance of the vagal nerve, thalamus, reticular activating system, and cortico-striatal-thalamic-cortical loop in the process of consciousness recovery.


2016 ◽  
Vol 97 (10) ◽  
pp. e92
Author(s):  
Rosa Martin-Mourelle ◽  
Sergio Otero-Villaverde ◽  
Carmen Crespo Lopez ◽  
Jorge Cabrera Sarmiento ◽  
Nelson Gaitan Perez ◽  
...  

2012 ◽  
pp. 96-110
Author(s):  
Silvia Zullo

Recent studies on patients in a vegetative state undergoing functional magnetic resonance imaging have allowed to better differentiate the vegetative state from the minimally conscious state and have shown the possibility that in the future we can detect the permanence in these patients of islands of consciousness. Such evidence might further increase the legal and moral dilemmas raised by these cases, since the scientific future advancements will make increasingly complex to apply the principle in dubio pro vita on the patient who provide signals in a reverse direction.


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