TVS: a trusted verification scheme for office documents based on blockchain

To realize the encryption of document information, authority authentication, and traceability of historical records, we propose a trusted verification scheme (TVS) for office documents to ensure security. Specifically, the scheme is realized by timestamps, smart contracts (or chaincode), and other blockchain technologies. It is based on the features of blockchain, such as security, credibility, immutability, and traceability of network behavior. And the TVS stores users and documents information through blockchain; it can monitor the state changes of office documents in real time by setting the trigger conditions of smart contracts. The experiment indicates that we have realized the real-time monitoring of data and the traceability of historical records. Moreover, we have achieved the purpose of document encryption and authority authentication, ensuring the authenticity and objectivity of data, avoiding the illegal tampering of malicious users to realize the trusted verification for documents.

The Regulation of Sleep

The words “regulation” and “control” have different meanings. A rich literature exists on the control mechanisms of sleep—the genomic, molecular, cellular, and circuit processes responsible for arousal state changes and characteristics. The regulation of sleep refers to functions and homeostatic maintenance of those functions. Much less is known about sleep regulation than sleep control, largely because functions of sleep are still unknown. Regulation requires information about the regulated variable that can be used as feedback information to achieve optimal levels. The circadian timing of sleep is regulated, and the feedback information is entraining stimuli such as the light–dark cycle. Sleep itself is homeostatically regulated, as evidenced by sleep deprivation experiments. Eletroenceophalography (EEG) slow-wave activity (SWA) is regulated, and it appears that adenosine is the major source of feedback information, and that fact indicates an energetic function for sleep. The last aspect of sleep regulation discussed in this short article is the non-rapid eye movement (NREM) and rapid eye movement (REM) sleep cycling. Evidence is discussed that supports the argument that NREM sleep is in a homeostatic relationship with wake, and REM sleep is in a homeostatic relationship with NREM sleep.

Lipid peroxidation functional state changes in patients with obstructive jaundice depending on the level of bilirubin in the blood

Obstructive jaundice (OJ) is the most common syndrome among diseases of the hepatopancreatoduodenal region and is found in 12-45% of cases. OJ may be benign and malignant etiology. Despite the evidence of the participation of bilirubin in reducing the bactericidal properties of neutrophils, there are no data currently on changes in the functioning of the antioxidant defense system depending on the level of bilirubin in the blood of patients with OJ of various origins. Research in this direction reveals the possibility for the development of pathogenetic recommendations for influencing these links of the pathogenesis of the disease. The study included men with OJ of non-malignant (OJNMG) (n = 47; mean age - 52.02 ± 5.18 years) and OJ of malignant genesis (OJMG) (I-II stages of the malignant process) (n = 45; mean age - 53.02 ± 4.8 years), divided into three subgroups, depending on the level of bilirubin in the blood. The indicators of practically healthy men as a control (n = 50, average age - 48.7 ± 3.9 years) were used. Spectrophotometric and statistical research methods were used. A statistically significant decrease of superoxide dismutase, glutathione-S-transferase, glutathione-peroxidase, ceruloplasmin, an increase in the values of diene conjugates, malondialdehyde in the group of patients with OJNMG relative to the control was revealed, regardless of the level of bilirubin in the blood. The presence of malignant genesis of the disease with more intense changes in the studied parameters relative to control is accompanied. Comparison of indicators between groups of patients with OJ of different genesis showed a decrease in the values of glutathione-S-transferase and an increase in the level of diene conjugates in patients with OJMG and the level of bilirubin less than 60 μmol / L, as well as an increase in the content of diene conjugates in patients with OJNMG and a level of bilirubin 60- 200 μmol / L in comparison with the corresponding groups of patients with OJNMG. Thus, both in the groups with OJNMG and in the groups with OJMG, there is a significant decrease in the activity of the main antioxidant enzymes and an increase in lipid peroxidation products, regardless of the level of bilirubin in the blood. The presence of malignant genesis is characterized by more intense differences. The revealed changes can serve as additional criteria for optimizing the diagnosis and treatment of this cohort of patients.

Care Triangle or Care Diamond? The Case of Childcare and Eldercare in Serbia

Overall changes in political, social and economic spheres in Serbia, along with ongoing demographic processes, have affected various policies and all aspects of people’s lives, including system(s) of care. While care became an important analytical concept and category of social policy analysis internationally, it has not been systematically applied in the analysis of the Serbian welfare state. Incorporation of care in welfare state analysis is much needed as its organisation in the national context reveals a lot about the nature of the welfare state, changes in its socio-institutional arrangements and, most importantly, the effects of provision. This article thus aims to outline the evolution of childcare and eldercare policies in Serbia over the last decade, employing the concept of the care diamond developed by Shahra Razavi, which allows examining the “architecture” through which the care is provided: families/ households, markets, the state and the voluntary sector. By analysing the prevalent care policy “architecture” for children and the elderly in Serbia and the roles of different sectors in that respect, as well as by identifying similarities and differences in the provision of childcare and eldercare in the national context, the article exposes developments and current state in childcare and eldercare provision in Serbia. The analysis indicates the profound role of the informal sphere in both care systems in Serbia, childcare and eldercare. Some differences between the two care domains could also be noted. These relate to the configuration of welfare sectors involved in care provision, revealing the modified shape of the care diamond in the case of childcare. That is, while all four sectors are involved in providing care in the case of eldercare forming an eldercare diamond, this is not the case with childcare. In the latter case, the voluntary, nonprofit sector does not exist as a care provider in Serbia, with childcare “architecture” having a shape of a care triangle. In light of this evidence, the role of families and the voluntary, nonprofit sector should be taken into account in future planning and funding of policies as well as in their implementation. Key words: care, childcare, eldercare, care diamond, policy, provision, Serbia

A Switching-Based Interference Control for Booster Separation of Hypersonic Vehicle

Whether launching from the ground or in the air, hypersonic vehicles need the booster to accelerate to a predetermined window, so as to meet the requirements of scramjet engine ignition. Therefore, there is interference suppression between boosters and hypersonic vehicles under the high dynamic pressure, which has become a key technical problem that affects the success of flight tests, especially when the aircraft is statically unstable. A method of variable structure switching-based control is proposed in this paper for rapid suppression on hypersonic vehicle booster separation interference. Switching control systems in real time according to state changes caused by flow field interference, the method can keep the attitude stability of hypersonic vehicle booster separation under the high dynamic pressure of static instability. The aerodynamic calculation model of the hypersonic vehicle booster separation process is established first, which adopts an unsteady solution and clarifies the aerodynamic interference characteristics of the afterbody on the vehicle in booster separation. Then, according to the characteristics of the flow field, the dynamics of the vehicle in and out of the interference area are converted into subsystems with switching characteristics. Using the dimension reduction and variable structure method, the switching control surface of the control system is established. On the basis of the vehicle state changes caused by flow field, the control system on the orbital change surface can be switched in real time to achieve stable attitude in the process of separation interference. Meanwhile, considering the additional interference torque generated by the afterbody to the vehicle in the separation process, a control system for interference suppression of the booster separation is designed. Simulation results verify that the designed control system can rapidly suppress the booster separation interference when the dynamic pressure is about 150 kPa and the vehicle has the static instability of 5%, thereby realizing the stable attitude of the vehicle.

Dynamic Characteristic Analysis of Spur Gear System Considering Tooth Contact State Caused by Shaft Misalignment

Shaft misalignment will change the gear contact state, and then leads to the variation of the internal stiffness excitation of the gear pair, and finally the dynamic characteristics of the gear system will be affected. However, the influence of the gear contact state change on stiffness is usually neglected in the traditional stiffness calculation model for misaligned gears, and the underlying influence mechanism of the gear contact state changes aroused by the shaft misalignment on the dynamic characteristics of gear system is still unclear. To address these shortcomings, traditional loaded tooth contact analysis (LTCA) model is improved with the influences of fillet foundation deformation taken into consideration. Combined with the improved LTCA model, a new mesh stiffness calculation model for misaligned gear considering the tooth contact state is proposed, and then the effects of the contact state changes aroused by the shaft misalignment on the mesh stiffness excitation are studied. Moreover, a dynamic model of misaligned gear system with 8 degree of freedom (DOF) is established, and the dynamic characteristics of the system are simulated and finally verified by experiment. The results show that the proposed model can be used to evaluate the dynamic characteristics of the misaligned gear system with the change of gear tooth contact state taken into consideration. This study provides a theoretical method for the evaluation and identification of the shaft misalignment error.

Ubiquity of human-induced changes in climate variability

While climate change mitigation targets necessarily concern maximum mean state changes, understanding impacts and developing adaptation strategies will be largely contingent on how climate variability responds to increasing anthropogenic perturbations. Thus far Earth system modeling efforts have primarily focused on projected mean state changes and the sensitivity of specific modes of climate variability, such as the El Niño–Southern Oscillation. However, our knowledge of forced changes in the overall spectrum of climate variability and higher-order statistics is relatively limited. Here we present a new 100-member large ensemble of climate change projections conducted with the Community Earth System Model version 2 over 1850–2100 to examine the sensitivity of internal climate fluctuations to greenhouse warming. Our unprecedented simulations reveal that changes in variability, considered broadly in terms of probability distribution, amplitude, frequency, phasing, and patterns, are ubiquitous and span a wide range of physical and ecosystem variables across many spatial and temporal scales. Greenhouse warming in the model alters variance spectra of Earth system variables that are characterized by non-Gaussian probability distributions, such as rainfall, primary production, or fire occurrence. Our modeling results have important implications for climate adaptation efforts, resource management, seasonal predictions, and assessing potential stressors for terrestrial and marine ecosystems.

New Remains of Scandiavis mikkelseni Inform Avian Phylogenetic Relationships and Brain Evolution

Although an increasing number of studies are combining skeletal and neural morphology data in a phylogenetic context, most studies do not include extinct taxa due to the rarity of preserved endocasts. The early Eocene avifauna of the Fur Formation of Denmark presents an excellent opportunity for further study of extinct osteological and endocranial morphology as fossils are often exceptionally preserved in three dimensions. Here, we use X-ray computed tomography to present additional material of the previously described taxon Scandiavis mikkelseni and reassess its phylogenetic placement using a previously published dataset. The new specimen provides novel insights into the osteological morphology and brain anatomy of Scandiavis. The virtual endocast exhibits a morphology comparable to that of modern avian species. Endocranial evaluation shows that it was remarkably similar to that of certain extant Charadriiformes, yet also possessed a novel combination of traits. This may mean that traits previously proposed to be the result of shifts in ecology later in the evolutionary history of Charadriiformes may instead show a more complex distribution in stem Charadriiformes and/or Gruiformes depending on the interrelationships of these important clades. Evaluation of skeletal and endocranial character state changes within a previously published phylogeny confirms both S. mikkelseni and a putative extinct charadriiform, Nahmavis grandei, as charadriiform. Results bolster the likelihood that both taxa are critical fossils for divergence dating and highlight a biogeographic pattern similar to that of Gruiformes.