Aortic Stiffness and Myocardial Ischemia

Pulse Waves ◽  
2016 ◽  
pp. 175-198
Author(s):  
Paolo Salvi
Keyword(s):  
Myocardial Ischemia ◽  
Aortic Stiffness

scholarly journals P3652High aortic stiffness and myocardial ischemia in non-obstructive coronary artery disease (the MicroCAD project)

2018 ◽  
Vol 39 (suppl_1) ◽  
Author(s):  
M T Lonnebakken ◽  
I Eskerud ◽  
T H Larsen ◽  
H Midtbo ◽  
M V Kokorina ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Myocardial Ischemia ◽  
Aortic Stiffness ◽  
Obstructive Coronary Artery Disease ◽  
Artery Disease

scholarly journals The Role of Aortic Stiffness Parameters in Evaluating Myocardial Ischemia

2020 ◽  
Vol 11 (5) ◽  
pp. 328-336
Author(s):  
Merve Kumrular ◽  
Pelin Karaca Ozer ◽  
Ali Elitok
Keyword(s):  
Myocardial Ischemia ◽  
Aortic Stiffness

Aortic stiffness and myocardial ischemia

2015 ◽  
Vol 33 (9) ◽  
pp. 1767-1771 ◽  
Author(s):  
Paolo Salvi ◽  
Gianfranco Parati
Keyword(s):  
Myocardial Ischemia ◽  
Aortic Stiffness

scholarly journals Remote Ischemic Perconditioning Ameliorates Myocardial Ischemia and Reperfusion-Induced Coronary Endothelial Dysfunction and Aortic Stiffness in Rats

2021 ◽  
pp. 107424842110313
Author(s):  
Petra Lujza Szabó ◽  
Christopher Dostal ◽  
Patrick Michael Pilz ◽  
Ouafa Hamza ◽  
Eylem Acar ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Endothelial Dysfunction ◽  
Myocardial Ischemia ◽  
Aortic Stiffness ◽  
Vascular Reactivity ◽  
Ventricular Remodeling ◽  
Left Ventricular ◽  
Ischemia And Reperfusion ◽  
Myocardial Ischemia And Reperfusion ◽  
Remote Ischemic Perconditioning

Background: Vascular stiffness and endothelial dysfunction are accelerated by acute myocardial infarction (AMI) and subsequently increase the risk for recurrent coronary events. Aim: To explore whether remote ischemic perconditioning (RIPerc) protects against coronary and aorta endothelial dysfunction as well as aortic stiffness following AMI. Methods: Male OFA-1 rats were subjected to 30 min of occlusion of the left anterior descending artery (LAD) followed by reperfusion either 3 or 28 days with or without RIPerc. Three groups: (1) sham operated (Sham, without LAD occlusion); (2) myocardial ischemia and reperfusion (MIR) and (3) MIR + RIPerc group with 3 cycles of 5 minutes of IR on hindlimb performed during myocardial ischemia were used. Assessment of vascular reactivity in isolated septal coronary arteries (non-occluded) and aortic rings as well as aortic stiffness was assessed by wire myography either 3 or 28 days after AMI, respectively. Markers of pro-inflammatory cytokines, adhesion molecules were assessed by RT-qPCR and ELISA. Results: MIR promotes impaired endothelial-dependent relaxation in septal coronary artery segments, increased aortic stiffness and adverse left ventricular remodeling. These changes were markedly attenuated in rats treated with RIPerc and associated with a significant decline in P-selectin, IL-6 and TNF-α expression either in infarcted or non-infarcted myocardial tissue samples. Conclusions: Our study for the first time demonstrated that RIPerc alleviates MIR-induced coronary artery endothelial dysfunction in non-occluded artery segments and attenuates aortic stiffness in rats. The vascular protective effects of RIPerc are associated with ameliorated inflammation and might therefore be caused by reduced inflammatory signaling.

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