Mitigating Radiation Effects on Humans During Space Travel: Recent Developments

2021 ◽  
pp. 1-33
Author(s):  
Gayatri Gopal Shetgaonkar ◽  
Lalit Kumar
Keyword(s):  
Radiation Effects ◽  
Space Travel ◽  
Recent Developments

Nutraceuticals for Reducing Radiation Effects During Space Travel

2021 ◽  
pp. 1-19
Author(s):  
Sweta Kulkarni ◽  
Dipal Gandhi ◽  
Priti J. Mehta
Keyword(s):  
Radiation Effects ◽  
Space Travel

scholarly journals Genetics, Bioethics and Space Travel: GATTACA

2012 ◽  
Vol 34 (6) ◽  
pp. 34-35
Author(s):  
Clare Sansom
Keyword(s):  
New World ◽  
Second World War ◽  
Human Biology ◽  
Space Travel ◽  
World War ◽  
The Future ◽  
Recent Developments ◽  
Brave New World ◽  
Genetics And Genomics ◽  
Second World

It has been said that all stories set in the future say more about the concerns of the time in which they are written than they do about future possibilities. Long before the genome era, writers were investigating the possibility of changing the biological make-up of humans. Questions about human biology, identity and eugenics (from the Greek ‘well-born’) have been raised by writers ever since Plato; classic novels addressing these issues include H.G. Wells's The Island of Doctor Moreau (1896) and Aldous Huxley's Brave New World (1931). Eugenics in fiction passed out of fashion after the Second World War, but recent developments in genetics and genomics have brought these ideas into the foreground again.

scholarly journals Radiation Biomarkers in Large Scale Human Health Effects Studies

2020 ◽  
Vol 10 (4) ◽  
pp. 155 ◽  
Author(s):  
Jayne Moquet ◽  
Kai Rothkamm ◽  
Stephen Barnard ◽  
Elizabeth Ainsbury
Keyword(s):  
Human Health ◽  
Health Effects ◽  
Radiation Effects ◽  
Large Scale ◽  
Epidemiological Studies ◽  
Data Sets ◽  
Recent Developments ◽  
Radiation Induced ◽  
Effort Effect ◽  
Human Health Effects

Following recent developments, the RENEB network (Running the European Network of biological dosimetry and physical retrospective dosimetry) is in an excellent position to carry out large scale molecular epidemiological studies of ionizing radiation effects, with validated expertise in the dicentric, fluorescent in situ hybridization (FISH)-translocation, micronucleus, premature chromosome condensation, gamma-H2AX foci and gene expression assays. Large scale human health effects studies present complex challenges such as the practical aspects of sample logistics, assay costs, effort, effect modifiers and quality control/assurance measures. At Public Health England, the dicentric, automated micronucleus and gamma-H2AX radiation-induced foci assays have been tested for use in a large health effects study. The results of the study and the experience gained in carrying out such a large scale investigation provide valuable information that could help minimise random and systematic errors in biomarker data sets for health surveillance analyses going forward.

scholarly journals Low-dose proton radiation effects in a transgenic mouse model of Alzheimer’s disease – Implications for space travel

PLoS ONE ◽  
2017 ◽  
Vol 12 (11) ◽  
pp. e0186168 ◽  
Author(s):  
Emil Rudobeck ◽  
John A. Bellone ◽  
Attila Szücs ◽  
Kristine Bonnick ◽  
Shalini Mehrotra-Carter ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Radiation Effects ◽  
Low Dose ◽  
Transgenic Mouse Model ◽  
Space Travel ◽  
Proton Radiation ◽  
Model Of Alzheimer’S Disease

Trends in Electron Energy Loss Spectroscopy

1977 ◽  
Vol 35 ◽  
pp. 228-229
Author(s):  
C. Colliex ◽  
P. Trebbia
Keyword(s):  
Energy Loss ◽  
Electron Energy ◽  
Electron Energy Loss Spectroscopy ◽  
Materials Science ◽  
Analytical Technique ◽  
Recent Developments ◽  
Quantitative Results ◽  
Electron Microscopes ◽  
Electron Energy Loss ◽  
Primary Electrons

The physical foundations for the use of electron energy loss spectroscopy towards analytical purposes, seem now rather well established and have been extensively discussed through recent publications. In this brief review we intend only to mention most recent developments in this field, which became available to our knowledge. We derive also some lines of discussion to define more clearly the limits of this analytical technique in materials science problems.The spectral information carried in both low ( 0<ΔE<100eV ) and high ( >100eV ) energy regions of the loss spectrum, is capable to provide quantitative results. Spectrometers have therefore been designed to work with all kinds of electron microscopes and to cover large energy ranges for the detection of inelastically scattered electrons (for instance the L-edge of molybdenum at 2500eV has been measured by van Zuylen with primary electrons of 80 kV). It is rather easy to fix a post-specimen magnetic optics on a STEM, but Crewe has recently underlined that great care should be devoted to optimize the collecting power and the energy resolution of the whole system.

Filaments and membranes in the mitotic apparatus

1983 ◽  
Vol 41 ◽  
pp. 544-547
Author(s):  
Kent McDonald
Keyword(s):  
Intermediate Filaments ◽  
Mitotic Spindle ◽  
Mitotic Apparatus ◽  
Light Microscope Level ◽  
Microtubule Associated Proteins ◽  
Recent Developments ◽  
Associated Proteins ◽  
Force Generator ◽  
Spindle Function ◽  
Antibody Technology

At the light microscope level the recent developments and interest in antibody technology have permitted the localization of certain non-microtubule proteins within the mitotic spindle, e.g., calmodulin, actin, intermediate filaments, protein kinases and various microtubule associated proteins. Also, the use of fluorescent probes like chlorotetracycline suggest the presence of membranes in the spindle. Localization of non-microtubule structures in the spindle at the EM level has been less rewarding. Some mitosis researchers, e.g., Rarer, have maintained that actin is involved in mitosis movements though the bulk of evidence argues against this interpretation. Others suggest that a microtrabecular network such as found in chromatophore granule movement might be a possible force generator but there is little evidence for or against this view. At the level of regulation of spindle function, Harris and more recently Hepler have argued for the importance of studying spindle membranes. Hepler also believes that membranes might play a structural or mechanical role in moving chromosomes.

Quantitative analysis of in situ straining experiments in the case of strong frictional forces

1978 ◽  
Vol 36 (1) ◽  
pp. 570-571
Author(s):  
F. Louchet ◽  
L.P. Kubin
Keyword(s):  
Strain Rate ◽  
Radiation Effects ◽  
Dislocation Line ◽  
Critical Length ◽  
Local Strain ◽  
Local Flow ◽  
Double Kink ◽  
Dislocation Densities ◽  
Frictional Forces ◽  
Local Strain Rate

Investigation of frictional forces -Experimental techniques and working conditions in the high voltage electron microscope have already been described (1). Care has been taken in order to minimize both surface and radiation effects under deformation conditions.Dislocation densities and velocities are measured on the records of the deformation. It can be noticed that mobile dislocation densities can be far below the total dislocation density in the operative system. The local strain-rate can be deduced from these measurements. The local flow stresses are deduced from the curvature radii of the dislocations when the local strain-rate reaches the values of ∿ 10-4 s-1.For a straight screw segment of length L moving by double-kink nucleation between two pinning points, the velocity is :where ΔG(τ) is the activation energy and lc the critical length for double-kink nucleation. The term L/lc takes into account the number of simultaneous attempts for double-kink nucleation on the dislocation line.

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