Gift-of-life? The Psychosocial Experiences of Heart, Liver and Kidney Recipients

2017 ◽  
pp. 215-237
Author(s):  
Geraldine O’Brien
Keyword(s):  
Psychosocial Experiences ◽  
Kidney Recipients ◽  
Liver And Kidney

scholarly journals Bacterial and Fungal Co-infections with SARS-CoV-2 in Solid Organ Recipients, A Retrospective Study

2021 ◽  
Author(s):  
Mojtaba Shafiekhani ◽  
Zahra Shekari ◽  
Arash Boorboor ◽  
Zahra Zare ◽  
Sara Arabsheybani ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Fungal Infections ◽  
Binary Logistic Regression ◽  
Risk Groups ◽  
Solid Organ ◽  
Binary Logistic Regression Model ◽  
Kidney Recipients ◽  
Susceptible Patient ◽  
Liver And Kidney ◽  
Vancomycin Resistant

Abstract Background SARS-CoV-2, a novel corona virus, has caused clusters of fatal pneumonia worldwide. Immune compromised patients are among the high risk groups with poor prognosis of the disease. The presence of bacterial or fungal co-infections with SARS-CoV-2 is associated with increased mortality.Methods The electronic data of the liver and kidney recipients, hospitalized in COVID-19 intensive care unit in an 8-month period in 2020 were retrospectively assessed. The documented bacterial or fungal infections alongside with outcome and risk factors were recorded and analyzed by binary logistic regression model and multivariate analyses.Results Sixty-Six liver and kidney recipients were included this study. Twenty one percent of the patients had at least one episode of co-infection during their COVID-19 course. Bacterial and fungal co-infections contributed to a significantly higher mortality. Urine and sputum were the most common sites of pathogen isolation (45.45 % and 36.36%; respectively). The majority of infections were caused by vancomycin- resistant Enterococci (30%). Escherichia coli stood in the next position with 23.3%. Prior hospitalization and high does corticosteroid use were associated with co-infections (p=0<0.001 and p=0.02; respectively.)Conclusions Bacterial and fungal co-infections with COVID-19 are more prevalent on solid organ recipients compared to the general population. Prior hospitalizations and use of broad-spectrum antimicrobial agents leads to emergence of multi-drug resistant pathogens in this susceptible patient population. Early detection and treatment of co-infections as well as antibiotic stewardship is recommended in solid organ recipients.

scholarly journals Bacterial and Fungal Co-infections with SARS-CoV-2 in Solid Organ Recipients, A Retrospective Study

2022 ◽  
Author(s):  
Mojtaba Shafiekhani ◽  
Zahra Shekari ◽  
Arash Boorboor ◽  
Zahra Zare ◽  
Sara Arabsheybani ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Fungal Infections ◽  
Binary Logistic Regression ◽  
Risk Groups ◽  
Solid Organ ◽  
Binary Logistic Regression Model ◽  
Kidney Recipients ◽  
Susceptible Patient ◽  
Liver And Kidney ◽  
Vancomycin Resistant

Abstract Background SARS-CoV-2, a novel corona virus, has caused clusters of fatal pneumonia worldwide. Immune compromised patients are among the high risk groups with poor prognosis of the disease. The presence of bacterial or fungal co-infections with SARS-CoV-2 is associated with increased mortality. Methods The electronic data of the liver and kidney recipients, hospitalized in COVID-19 intensive care unit in an 8-month period in 2020 were retrospectively assessed. The documented bacterial or fungal infections alongside with outcome and risk factors were recorded and analyzed by binary logistic regression model and multivariate analyses. Results Sixty-Six liver and kidney recipients were included this study. Twenty one percent of the patients had at least one episode of co-infection during their COVID-19 course. Bacterial and fungal co-infections contributed to a significantly higher mortality. Urine and sputum were the most common sites of pathogen isolation (45.45 % and 36.36%; respectively). The majority of infections were caused by vancomycin- resistant Enterococci (30%). Escherichia coli stood in the next position with 23.3%. Prior hospitalization and high does corticosteroid use were associated with co-infections (p=0<0.001 and p=0.02; respectively.)Conclusions Bacterial and fungal co-infections with COVID-19 are more prevalent in solid organ recipients compared to the general population. Prior hospitalizations and use of broad-spectrum antimicrobial agents lead to emergence of multi-drug resistant pathogens in this susceptible patient population. Early detection and treatment of co-infections as well as antibiotic stewardship is recommended in solid organ recipients.

A Single-Center Assessment of Delayed Graft Function in Recipients of Simultaneous Liver and Kidney Transplant

2020 ◽  
Vol 30 (4) ◽  
pp. 342-348
Author(s):  
Fahad Aziz ◽  
Ali Gardezi ◽  
Brenda Muth ◽  
Justin Blazel ◽  
Neetika Garg ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Graft Function ◽  
Delayed Graft Function ◽  
Kidney Graft ◽  
Kidney Allograft ◽  
Risk Of Death ◽  
Kidney Recipients ◽  
Allograft Failure ◽  
Liver And Kidney ◽  
Multiple Variables

Background: The effects of delayed graft function on long-term kidney allograft outcomes are poorly defined among simultaneous liver and kidney transplant recipients. Methods: We analyzed data of all simultaneous liver and kidney recipients transplanted at the University of Wisconsin between 2010 and 2017. Risk factors for the development of delayed graft function, kidney graft failure, and patient mortality were outcomes of interest. Results: There were a total of 60 simultaneous liver and kidney recipients; 28 (47%) had delayed graft function. After adjustment for multiple variables, we found that pretransplant dialysis >6 weeks (hazard ratio [HR] = 5.6, 95% CI: 1.23-25.59, P = .02), pretransplant albumin <3 g/dL (HR = 5.75, 95% CI: 1.76-16.94, P = .003), and presence of pretransplant diabetes (HR = 2.5, 95% CI: 0.97-4.77, P = .05) were significantly associated with delayed graft function. Multivariate analysis showed that pretransplant albumin <3 (HR = 4.86, 95% CI: 1.07-22.02, P = .02) was associated with a higher risk of all-cause kidney allograft failure, whereas the duration of delayed graft function (HR = 1.07 per day, 95% CI: 1.01-1.14, P = .01) was associated with a higher risk of death-censored kidney allograft failure. The presence of delayed graft function was not associated with all-cause or death-censored kidney or liver allograft failure. Similarly, the presence of delayed graft function was not associated with patient mortality. Conclusion: The incidence of delayed graft function was high in simultaneous liver and kidney recipients. However, with appropriate management, delayed graft function may not have a negative impact on patient or kidney allograft survival.

Pretransplant CD28 Biomarker (Levels of Expression and Quantification of Molecules per Cell) in Peripheral CD4+ T Cells Predicts Acute Rejection Episodes in Liver and Kidney Recipients

2016 ◽  
Vol 48 (9) ◽  
pp. 2987-2989 ◽  
Author(s):  
F. Boix ◽  
J.M. Bolarín ◽  
J. Eguía ◽  
G. Gonzalez-Martinez ◽  
J. De La Peña ◽  
...  
Keyword(s):  
T Cells ◽  
Acute Rejection ◽  
Cd4 T Cells ◽  
Kidney Recipients ◽  
Liver And Kidney

The Utility of Donor Specific Antibody Monitoring and the Role of Kidney Biopsy in Simultaneous Liver and Kidney recipients with denovo Donor Specific Antibodies

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Sandesh Parajuli ◽  
Fahad Aziz ◽  
Justin Blazel ◽  
Brenda L. Muth ◽  
Neetika Garg ◽  
...  
Keyword(s):  
Specific Antibody ◽  
Kidney Biopsy ◽  
Specific Antibodies ◽  
Kidney Recipients ◽  
Liver And Kidney ◽  
Donor Specific Antibodies

scholarly journals Transfusion Status in Liver and Kidney Transplantation Recipients—Results from Nationwide Claims Database

2020 ◽  
Vol 9 (11) ◽  
pp. 3613
Author(s):  
Boyoung Park ◽  
Junghyun Yoon ◽  
Han Joon Kim ◽  
Yun Kyung Jung ◽  
Kyeong Geun Lee ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Mortality Rate ◽  
Deceased Donor ◽  
Sociodemographic Factors ◽  
Fresh Frozen Plasma ◽  
Transfusion Rate ◽  
Solid Organ ◽  
Kidney Recipients ◽  
Fresh Frozen ◽  
Liver And Kidney

Background: This study analyzed the status and trends of transfusion and its associated factors among liver and kidney transplantation recipients. Methods: A total of 10,858 and 16,191 naïve liver or kidney transplantation recipients from 2008 to 2017 were identified through the National Health Insurance Service database. The prescription code for transfusion and the presence, number, and amount of each type of transfusion were noted. The odds ratios and 95% confidence intervals were determined to identify significant differences in transfusion and blood components by liver and kidney transplantation recipient characteristics. Results: In this study, 96.4% of liver recipients and 59.7% of kidney recipients received transfusions related to the transplantation operation, mostly platelet and fresh frozen plasma. Higher perioperative transfusion in women and declining transfusion rates from 2008 to 2017 were observed in both liver and kidney recipients. In liver recipients, the transfusion rate in those who received organs from deceased donors was much higher than that in those who received organs from living donors; however, the mortality rate according to transfusion was higher only in recipients of deceased donor organs. In kidney recipients, a higher mortality rate was observed in those receiving transfusion than that in patients without transfusion. Conclusions: In Korea, the transfusion rates in liver and kidney recipients were relatively higher than those in other countries. Sociodemographic factors, especially sex and year of transplantation, were associated with transfusion in solid organ recipients, possibly as surrogates for other causal clinical factors.

scholarly journals Early postoperative seizures in liver and kidney recipients

2021 ◽  
Vol 23 (2) ◽  
pp. 158-166
Author(s):  
O. M. Tsirulnikova ◽  
A. V. Syrkina ◽  
I. A. Miloserdov ◽  
I. E. Pashkova ◽  
S. Yu. Oleshkevich ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Neurological Complications ◽  
Outcome Data ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Important Place ◽  
Kidney Recipients ◽  
Liver And Kidney ◽  
Symptomatic Seizures ◽  
Acute Symptomatic Seizures

Background. Transplantation is presently the only treatment for end-stage liver and kidney failure. Up to 42% of liver transplant recipients and up to 30% of kidney transplant recipients have neurological complications from the transplantation. Acute symptomatic seizures (ACS) occupy an important place in the structure of early postoperative neurological complications. Verification of the causes of seizures and management of the risk of relapse is presently a critical task.Objective: to review recent advances in ACS assessment, prevalence, and treatment approaches in liver and kidney transplant recipients.Materials and methods. The causes of ACS after liver and kidney transplant are diverse. Nonspecific causes of seizures such as dysmetabolic and volemic changes associated with transplantation are widely known. There are also specific syndromes associated with seizures in liver and kidney recipients, such as posterior reversible leukoencephalopathy syndrome, neurotoxicity of calcineurin inhibitors, hyponatremia in the final stage of liver failure, hypocalcemia in kidney recipients, etc. Diagnosis is made based on general rules, and treatment depends on the identified causes of seizures. Management of acute symptomatic seizures involves prescribing anticonvulsants according to the risk of seizure recurrence; immunosuppression is converted when neurotoxicity is identified. Results. The diagnostic algorithm, and often the treatment strategies, in ACS cases in liver and kidney recipients, are not clearly defined.Conclusion. Due to the multiple causes of ACS, there are differences in treatment tactics. Further accumulation and generalization of ACS outcome data will help in creating a convenient algorithm for rapid identification of the cause and the most effective treatment tactics.

Comparison of Transcriptional and Blood Cell-Phenotypic Markers Between Operationally Tolerant Liver and Kidney Recipients

2011 ◽  
Vol 11 (9) ◽  
pp. 1916-1926 ◽  
Author(s):  
J. J. Lozano ◽  
A. Pallier ◽  
M. Martinez-Llordella ◽  
R. Danger ◽  
M. López ◽  
...  
Keyword(s):  
Blood Cell ◽  
Phenotypic Markers ◽  
Kidney Recipients ◽  
Liver And Kidney

scholarly journals Attitudes towards transplantation and medication among 121 heart, lung, liver and kidney recipients and their spouses

2012 ◽  
Author(s):  
L Goetzmann ◽  
U Scholz ◽  
R Dux ◽  
M Roellin ◽  
A Boehler ◽  
...  
Keyword(s):  
Kidney Recipients ◽  
Liver And Kidney

scholarly journals In vitro intracellular IFNγ, IL-17 and IL-10 producing T cells correlates with the occurrence of post-transplant opportunistic infection in liver and kidney recipients

2018 ◽  
Vol 8 (1) ◽  
pp. 23-37
Author(s):  
Francisco Boix ◽  
Santiago Llorente ◽  
Jorge Eguía ◽  
Gema Gonzalez-Martinez ◽  
Rafael Alfaro ◽  
...  
Keyword(s):  
T Cells ◽  
Opportunistic Infection ◽  
Post Transplant ◽  
Kidney Recipients ◽  
Liver And Kidney
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