Platelet Rich Fibrin “PRF” and Regenerative Medicine: ‘The Low-Speed Concept’

Multiple techniques have been described for dorsal nasal augmentation in rhinoplasty. In this article, we review common surgical techniques for raising the dorsum or eliminating dorsal irregularities, by highlighting inherent advantages and disadvantages of each method. Within the past few years, the use of diced cartilage grafts has become the workhorse in this field of interest. To overcome drawbacks of methods based on diced cartilage, we present a new concept for autologous augmentation, using regenerative medicine protocols. A mix of cartilage scales with cartilage pâté was embedded in platelet-rich fibrin (PRF). Since December 2015, a total of 48 patients were treated with this technique. Based on our preliminary results, cartilage scales in PRF appear to be a promising and reliable alternative to existing procedures for dorsal nasal augmentation.

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Extraction of blood mesenchymal stem cells with the low speed centrifugation concept: Applications in regenerative medicine

Journal of Stem Cell Research & Therapy ◽

10.4172/2157-7633-c4-041 ◽

2018 ◽

Vol 08 ◽

Author(s):

Joseph Choukroun

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Regenerative Medicine ◽

Low Speed

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Leucocyte- and platelet-rich fibrin (L-PRF) as a regenerative medicine strategy for the treatment of refractory leg ulcers: a prospective cohort study

Platelets ◽

10.1080/09537104.2017.1327654 ◽

2017 ◽

Vol 29 (5) ◽

pp. 468-475 ◽

Cited By ~ 29

Author(s):

Nelson R. Pinto ◽

Matias Ubilla ◽

Yelka Zamora ◽

Verónica Del Rio ◽

David M. Dohan Ehrenfest ◽

...

Keyword(s):

Cohort Study ◽

Regenerative Medicine ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Leg Ulcers ◽

Platelet Rich Fibrin

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Reduction of relative centrifugal forces increases growth factor release within solid platelet-rich-fibrin (PRF)-based matrices: a proof of concept of LSCC (low speed centrifugation concept)

European Journal of Trauma and Emergency Surgery ◽

10.1007/s00068-017-0785-7 ◽

2017 ◽

Vol 45 (3) ◽

pp. 467-479 ◽

Cited By ~ 28

Author(s):

K. El Bagdadi ◽

A. Kubesch ◽

X. Yu ◽

S. Al-Maawi ◽

A. Orlowska ◽

...

Keyword(s):

Growth Factor ◽

Proof Of Concept ◽

Centrifugal Forces ◽

Platelet Rich Fibrin ◽

Low Speed ◽

Growth Factor Release ◽

Factor Release

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Closure of an Oroantral Communication Using Leucocyte-Platelet Rich Fibrin: A Novel Technique Using Regenerative Medicine

Journal of Dental and Maxillofacial Surgery ◽

10.18314/jdms.v2i1.1540 ◽

2019 ◽

pp. 101-106

Author(s):

Cameron Y Lee

Keyword(s):

Soft Tissue ◽

Regenerative Medicine ◽

Venous Blood ◽

Postoperative Recovery ◽

Advancement Flap ◽

Posterior Teeth ◽

Platelet Rich Fibrin ◽

Soft Tissue Regeneration ◽

Novel Technique ◽

Oroantral Communication

Oroantral communication (OAC) is a common complication following extraction of maxillary posterior teeth because of the close anatomic proximity of the roots to the maxillary sinus. The most frequent methods described in the literature to close an oroantral communication involve buccal or palatal rotational advancement flap surgery or use of the buccal fat pad. These surgical procedures require advanced surgical skill and are associated with donor sit morbidity, such as avascular flap necrosis that can lead to soft tissue graft failure to close the OAC, infection and extreme postoperative patient discomfort that affects patient quality of life. This paper describes a novel technique using leucocyte platelet-rich fibrin matrix obtained from the patient’s own venous blood that leads to predictable soft tissue regeneration and closure of the OAC. This regenerative medicine procedure is clinician friendly, less traumatic compared to traditional methods of OAC closure with minimal postoperative recovery for the patient.

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