Prevention and Treatment of Infectious Complications in Haploidentical SCT

Author(s):  
Angela Haßler ◽  
Thomas Lehrnbecher ◽  
Peter Bader ◽  
Thomas Klingebiel
2020 ◽  
Vol 12 (4) ◽  
pp. 57-65
Author(s):  
Vladimir V. Brzheskiy

The development of inflammatory diseases of the cornea and conjunctiva, as well as the occurrence of infectious complications of intraocular surgery, are largely associated with the presence of saprophytic and pathogenic microflora in the conjunctival cavity. This circumstance is more characteristic of children. At the same time, the possibilities of antibacterial therapy of inflammatory eye diseases of bacterial and chlamydial etiology, as well as perioperative prophylaxis of infectious complications of intraocular surgical procedures in children, have significantly expanded today. The widespread use of fluoroquinolones has significantly improved the treatment of children with acute and chronic bacterial conjunctivitis, keratitis, blepharitis, meibomyitis, chalazion, as well as those with chronic conjunctivitis of chlamydial etiology. At the same time, levofloxacin fluoroquinolone of the 3rd generation, which is used in our country in the form of a 0.5% solution as eye drops Oftaquix (Santen, Finland), has demonstrated high efficacy for this purpose. The widespread introduction of the original 0.5% levofloxacin (Oftaquix), in the treatment regimen for children with inflammatory diseases of the cornea and conjunctiva, as well as for a perioperative prevention of infectious complications of surgical procedures involving them, is a promising way to solve the problem.


Blood ◽  
2014 ◽  
Vol 124 (19) ◽  
pp. 2913-2920 ◽  
Author(s):  
Caron Jacobson ◽  
Ann LaCasce

Abstract Burkitt lymphoma (BL) is an aggressive B-cell non-Hodgkin lymphoma that is almost uniformly associated with translocations involving the gene for MYC on chromosome 8. The 3 subtypes of BL, endemic, sporadic, and immunodeficiency-associated, differ from epidemiologic and clinical perspectives but may be genetically similar. Prompt administration of multiagent immunochemotherapy regimens is associated with favorable outcomes for the majority of patients. Survival is inferior in older patients, likely reflecting increased therapy-related toxicity, possibly resulting in decreased treatment intensity. Central nervous system prophylaxis, tumor lysis prevention and treatment, and management of infectious complications from myelosuppressive regimens are critical. Prognosis of refractory or relapsed disease is poor and patients are best treated on clinical trials when available.


JBMTCT ◽  
2021 ◽  
Vol 4 (1) ◽  
pp. 197-217
Author(s):  
Sociedade Brasileira de TMO SBTMO ◽  
Marcia Garnica Maiolino ◽  
Fabianne Carlesse ◽  
Jessica Fernandes Ramos

THE BRAZILIAN SOCIETY FOR BLOOD AND MARROW TRANSPLANTATION (SBTMO) PRESENTS THE BRAZILIAN GUIDELINES ON HEMATOPOIETIC STEM CELL TRANSPLANTATION


2014 ◽  
Vol 20 (29) ◽  
pp. 48-54
Author(s):  
Касохова ◽  
V. Kasokhova ◽  
Фидарова ◽  
A. Fidarova ◽  
Касохов ◽  
...  

The informations about current opportunities therapy of bronchopulmonary dysplasia in children is presented in this review. Their assessment on the basis of the results of various studies carried out on the principles of evidence medicine was performed. The main achievements and problems in the treatment of bronchopulmonary dysplasia were revealed. The information about the principles of effective respiratory support, the principles of systemic and inhaled corticosteroids use, about the prospects for the late appointment of surfactant in children with bronchopulmonary dysplasia, etc. was presented. The questions of prevention and treatment of infectious complications of bronchopulmonary dysplasia were highlighted. The prospects of the therapy of this disease in children were determined.


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