Role of Heat Shock Proteins in Oxidative Stress and Stress Tolerance

2018 ◽  
pp. 109-126 ◽  
Author(s):  
Sumit Ghosh ◽  
Poulami Sarkar ◽  
Priyanka Basak ◽  
Sushweta Mahalanobish ◽  
Parames C. Sil
Keyword(s):  
Oxidative Stress ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Stress Tolerance ◽  
Shock Proteins

The role of oxidative stress in the induction of Drosophila heat-shock proteins

1987 ◽  
Vol 173 (2) ◽  
pp. 439-449 ◽  
Author(s):  
Ian A.S. Drummond ◽  
Richard A. Steinhardt
Keyword(s):  
Oxidative Stress ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Shock Proteins

scholarly journals Heat Shock Proteins in Oxidative Stress and Ischemia/Reperfusion Injury and Benefits from Physical Exercises: A Review to the Current Knowledge

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Jakub Szyller ◽  
Iwona Bil-Lula
Keyword(s):  
Oxidative Stress ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Current Knowledge ◽  
Ischemia Reperfusion ◽  
Physical Exercises ◽  
Shock Proteins

Heat shock proteins (HSPs) are molecular chaperones produced in response to oxidative stress (OS). These proteins are involved in the folding of newly synthesized proteins and refolding of damaged or misfolded proteins. Recent studies have been focused on the regulatory role of HSPs in OS and ischemia/reperfusion injury (I/R) where reactive oxygen species (ROS) play a major role. ROS perform many functions, including cell signaling. Unfortunately, they are also the cause of pathological processes leading to various diseases. Biological pathways such as p38 MAPK, HSP70 and Akt/GSK-3β/eNOS, HSP70, JAK2/STAT3 or PI3K/Akt/HSP70, and HSF1/Nrf2-Keap1 are considered in the relationship between HSP and OS. New pathophysiological mechanisms involving ROS are being discovered and described the protein network of HSP interactions. Understanding of the mechanisms involved, e.g., in I/R, is important to the development of treatment methods. HSPs are multifunctional proteins because they closely interact with the antioxidant and the nitric oxide generation systems, such as HSP70/HSP90/NOS. A deficiency or excess of antioxidants modulates the activation of HSF and subsequent HSP biosynthesis. It is well known that HSPs are involved in the regulation of several redox processes and play an important role in protein-protein interactions. The latest research focuses on determining the role of HSPs in OS, their antioxidant activity, and the possibility of using HSPs in the treatment of I/R consequences. Physical exercises are important in patients with cardiovascular diseases, as they affect the expression of HSPs and the development of OS.

Role of heat shock proteins HSP70 and HSP32 in the protective effect of adaptation of cultured HT22 hippocampal cells to oxidative stress

2007 ◽  
Vol 144 (2) ◽  
pp. 174-177 ◽  
Author(s):  
I. P. Khomenko ◽  
L. Yu. Bakhtina ◽  
O. M. Zelenina ◽  
S. V. Kruglov ◽  
E. B. Manukhina ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Protective Effect ◽  
Shock Proteins

scholarly journals Role of Heat Shock Proteins in Improving Heat Stress Tolerance in Crop Plants

2016 ◽  
pp. 283-307 ◽  
Author(s):  
Palakolanu Sudhakar Reddy ◽  
Thammineni Chakradhar ◽  
Ramesha A. Reddy ◽  
Rahul B. Nitnavare ◽  
Srikrishna Mahanty ◽  
...  
Keyword(s):  
Heat Stress ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Stress Tolerance ◽  
Crop Plants ◽  
Heat Stress Tolerance ◽  
Shock Proteins

Oxidative parameters and expression of 70kDa heat shock proteins in pig heart tissue after transport and slaughter

2014 ◽  
Vol 17 (3) ◽  
pp. 433-439
Author(s):  
R. Urban-Chmiel ◽  
R. Pyz-Łukasik ◽  
A. Dudzic ◽  
A. Wernicki
Keyword(s):  
Oxidative Stress ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Western Blotting ◽  
Thiobarbituric Acid ◽  
Heart Tissue ◽  
Markers Of Oxidative Stress ◽  
Effects Of Stress ◽  
Shock Proteins

Abstract In view of the significant role of Hsp70 in protecting the organism against the destructive effects of stress, and the possibility of using this protein as a marker of the infarction process in the heart, the aim of this study was to conduct an evaluation of the expression of 70kDa heat shock proteins (Hsp70) and the concentration of TBARS (thiobarbituric acid reactive substances) and nitric oxide ions (NO), determined as nitrite ions, as markers of oxidative stress in hearts obtained from healthy pigs following slaughter and pigs which had died during or immediately after transport with symptoms of sudden cardiac death. The material consisted of hearts obtained from 90 pigs following slaughter and from pigs which had died. Oxidative stress was determined in heart lysates based on the concentration of TBARS and nitrite ions. Expression and concentration of Hsp70 were determined using SDS-PAGE, Western blotting, and ELISA. Expression of Hsp70 was observed in hearts lysates obtained from slaughtered pigs and from those which had died with symptoms of sudden death. The strongest reaction in the Western Blotting was noted in hearts lysates from pigs with no pathological changes. The highest TBARS concentration was observed in lysates from hearts in pigs which had died during or immediately after transport. The highest concentration of NO ions, determined as nitrite ions, was noted in hearts from pigs with myocardial infarction lesions. The significant decrease observed in Hsp70 concentration in heart tissue obtained from the pigs which had died in comparison to the hearts from healthy pigs indicates the important role of this protein in protecting the heart muscle against the destructive effects of stress, which limits the occurrence of post-stress cardiomyopathy in pigs following transport.

scholarly journals Investigating the role of plant heat shock proteins during oxidative stress

2008 ◽  
Vol 3 (10) ◽  
pp. 856-857 ◽  
Author(s):  
Telma E. Scarpeci ◽  
María I. Zanor ◽  
Estela M. Valle
Keyword(s):  
Oxidative Stress ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Shock Proteins

The role of heat shock proteins in oxidative stress damage induced by Se deficiency in chicken livers

BioMetals ◽  
2014 ◽  
Vol 28 (1) ◽  
pp. 163-173 ◽  
Author(s):  
C. P. Liu ◽  
J. Fu ◽  
F. P. Xu ◽  
X. S. Wang ◽  
S. Li
Keyword(s):  
Oxidative Stress ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Se Deficiency ◽  
Stress Damage ◽  
Shock Proteins
Sign in / Sign up

Export Citation Format

Share Document