On the Weaknesses of Function Table Randomization

Author(s):  
Moritz Contag ◽  
Robert Gawlik ◽  
Andre Pawlowski ◽  
Thorsten Holz
Keyword(s):  
Author(s):  
Mihyeon Ahn ◽  
Kwangho Lee ◽  
Hwajin Seo ◽  
Young Joo Yoon
Keyword(s):  
The Gaze ◽  

2014 ◽  
Vol 32 (3_suppl) ◽  
pp. 181-181
Author(s):  
Stephen Lam Chan ◽  
Philip James Johnson ◽  
Frankie Mo ◽  
Sarah Berhane ◽  
Brigette Ma ◽  
...  

181 Background: There have been few international studies that systematically evaluate the impact of geographical region on the prognosis of HCC. Methods: Prospective cohorts of patients (pt) were accrued in UK (n=567; 2006-2011) and HK (n=517; 2007-2012). Clinical data were documented at baseline; treatments were decided by multidisciplinary teams at both centers. Results: The median follow-up time of the UK and HK cohort was 27.9 and 29.8 months, respectively. The median overall survival (OS) of the whole UK and HK cohort was 22.9 months and 8.6 months. In the HK cohort, 425 underwent palliative treatment (TACE, systemic agents or supportive care) and 92 had curative treatment (surgery and locoablation); in the UK cohort, 338 had palliative treatment and 228 underwent curative treatment. In the curative group, the median OS was 54.8 months in the UK cohort but has not yet been achieved in the HK cohort. For the palliative group, the median OS was 12.7 and 5.5 months in the UK and HK cohort respectively. In the palliative group, geographical difference was an independent prognostic factor (HK vs. UK, HR=2.0; p<0.0001). Other prognostic factors were mainly tumorous features and Child’s liver function (Table). In the curative group, neither geographical difference nor Child’s score were prognostic factors. Conclusions: Separate prognostic factors exist for curative and palliative treatment. Geographical differences need to be considered during design of clinical trials on novel agents where palliative treatments are investigated but not for surgery or locoablation. [Table: see text]


Author(s):  
Hyun-gi Kim ◽  
Sungchan Kim ◽  
Byung-Geun Ha

In this study, for the purpose of conducting the structural tests for the verification of structural soundness of the flight-load conditions of the external fuel tank for the fixed-wing aircraft, the flight load acting on the external fuel tank was converted to test load and the suitability of the converted loads was verified. The loads imposed on the external fuel tank were expressed as the combination of the inertial load (based on the acceleration in the translational direction) and the tangential direction inertial load (based on the angular acceleration of the moment). To calculate the test load, the transfer function table was generated by calculating the shear load and moment based on the unit load. For this purpose, a transfer function table was established by dividing the external fuel tank into a few sections and calculating the shear load and moment generated by the unit shear load and unit moment in each section. In addition, the test load for each section was calculated by computing the established transfer function table and flight-load conditions. However, in actual structural tests, it is often not possible to impose a load in the same position as the point at which the shear load and moment are calculated. For this reason, the actual test-load positions had to be determined and the calculated test loads were redistributed to those positions. Then, the final test load plan was established by applying a whiffle tree to increase the efficiency of the test while also making it easier to apply the actuators. Finally, the suitability of the established test load plan was confirmed by comparison with the flight-load conditions.


2013 ◽  
Vol 41 (3) ◽  
pp. 756-757 ◽  
Author(s):  
Samuel A. Collins ◽  
Jane S.A. Lucas ◽  
Hazel M. Inskip ◽  
Keith M. Godfrey ◽  
Graham Roberts ◽  
...  

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