Study on the test load for the structural test of the flight-load condition of the external fuel tank for fixed-wing aircraft

In this study, for the purpose of conducting the structural tests for the verification of structural soundness of the flight-load conditions of the external fuel tank for the fixed-wing aircraft, the flight load acting on the external fuel tank was converted to test load and the suitability of the converted loads was verified. The loads imposed on the external fuel tank were expressed as the combination of the inertial load (based on the acceleration in the translational direction) and the tangential direction inertial load (based on the angular acceleration of the moment). To calculate the test load, the transfer function table was generated by calculating the shear load and moment based on the unit load. For this purpose, a transfer function table was established by dividing the external fuel tank into a few sections and calculating the shear load and moment generated by the unit shear load and unit moment in each section. In addition, the test load for each section was calculated by computing the established transfer function table and flight-load conditions. However, in actual structural tests, it is often not possible to impose a load in the same position as the point at which the shear load and moment are calculated. For this reason, the actual test-load positions had to be determined and the calculated test loads were redistributed to those positions. Then, the final test load plan was established by applying a whiffle tree to increase the efficiency of the test while also making it easier to apply the actuators. Finally, the suitability of the established test load plan was confirmed by comparison with the flight-load conditions.

Knowledge Modeling in Troubleshooting

Introduction. The article describes the approach to solving the problem of complex technical system troubleshooting based on expert knowledge modeling. Intelligent information systems are widely used to solve the problems of diagnostics of multilevel systems including combine harvesters. The formal description of the subject domain knowledge is the framework for building the knowledge base of these systems. The sequence of creating an expert system knowledge base in accordance with production rules is considered. Materials and Methods. The approach is founded on the fault function table. As the object of diagnostics, one of the subsystems of the combine harvester electric equipment “opening the hopper roof flaps” is considered. The basis for constructing a sequence of elementary checks is a system of logical equations describing both the serviceable and possible faulty states of the subsystem. Results. A structural logic model is developed. As a result of analyzing the fault function table, the sets of elementary checks are determined. Four criteria have been used to analyze the weight of these checks. The authors have determined optimal sequence of checks and have developed a decision tree, which allows finding the cause of the malfunction and is the basis for creating the knowledge base of an intelligent information system. A fragment of the knowledge base is given. Discussion and Conclusion. The proposed approach of expert knowledge modelling increases the efficiency of the unit for troubleshooting of the intelligent decision support system. It makes possible to structure the base of expertise and establishing the optimal sequence of elementary checks. This allows determining the optimal sequence of application of the knowledge base production rule that makes it possible to reduce the time of restoring the serviceability of combines.

DREAMM-2: Single-agent belantamab mafodotin (GSK2857916) in patients with relapsed/refractory multiple myeloma (RRMM) and renal impairment.

8519 Background: Renal impairment, a frequent complication and poor prognostic factor in RRMM, often leads to poor tolerability of standard regimens. We report outcomes in patients with renal impairment receiving single-agent belantamab mafodotin (2.5 or 3.4 mg/kg; B-cell maturation antigen targeting immunoconjugate not renally metabolized) from the DREAMM-2 post-hoc analysis (NCT03525678). Methods: Eligible patients with RRMM had no active renal conditions and adequate renal function (based on albumin/creatinine ratio [<500 mg/g] and eGFR [mL/min/1.73 m2]: normal [≥90], mild impairment [mild, ≥60≤90], moderate impairment [mod, ≥30≤60]). Results: Overall response rates (95% CI) in patients with mild/mod impairment (2.5 mg/kg: 32% [21.4–44.0]; 3.4 mg/kg: 36% [25.6–48.5]) were similar to those in the overall population ( Lancet Oncol.2020). The median duration of response (DoR) was not reached (NR) in 2.5 mg/kg mild/mod subgroup (95% CI estimate: 4.2 months–NR); median DoR was 7.5 months (4.9–NR) in 3.4 mg/kg mild/mod subgroup. Rates of keratopathy and albuminuria were similar regardless of renal function; rates of anemia, pyrexia, and thrombocytopenia were more frequent in patients with impaired renal function (Table). eGFR did not change or changed to normal in most patients. Conclusions: Following treatment with single-agent belantamab mafodotin, patients with mild/mod renal impairment achieved a similar efficacy and safety profile as patients with normal renal function. Funding: GlaxoSmithKline (205678). Drug linker technology licensed from Seattle Genetics; monoclonal antibody produced using POTELLIGENT Technology licensed from BioWa. Clinical trial information: NCT03525678 . [Table: see text]

Chemotherapy-induced ovarian failure (CIOF) in young women with early breast cancer (EBC).

10068 Background: Women ≤45 years (yrs) treated with chemotherapy (CT) for EBC have a high risk of developing CIOF. Awareness of CIOF is essential for young women. Methods: 740 patients (pts) aged ≤45yrs treated with anthracycline or taxane-based CT for EBC from 4 German neoadjuvant/adjuvant trials were included. Blood samples were collected at baseline (N=740), end of treatment (EOT n=740), 6 (n=177), 12 (n=113), 18 (n=69), 24 (n=47) months (m) after EOT. Only samples collected in a time sequence were included. Estradiol (E2), Follicle-Stimulating Hormone (FSH) and Anti-Müllerian Hormone (AMH) were centrally assessed. CIOF was defined as FSH >12.4IU/l and E2 <52.2ng/ml and was analysed per timepoint and according to clinical and treatment-related variables. Results: Median age was 40yrs (range 21-45); 57.2% had BMI 18.5-<25, 41.1% ≥25; 32% had luminal, 35.9% HER2+, 32.0% triple-negative BC. Median hormone levels at baseline for pts <30yrs vs 30-40yrs vs ≥40yrs were: FSH 5.2IU/I vs 5.6IU/I vs 6.4IU/I; E2 101ng/l vs 86ng/l vs 88ng/l; AMH 2.14ng/ml vs 1.58ng/ml vs 0.53ng/ml. 85.7% of pts had CIOF at EOT, 62.2% at 6m, 54.0% at 12m, 43.5% at 18m, 38.3% at 24m. Similar results were observed in 47 pts with all timepoint samples available. Older vs younger pts had more frequently CIOF at EOT (≥40yrs 94.6%, 30-40yrs 82.0%, <30yrs 50.0%, p<0.001). CIOF at EOT was not influenced by BMI. CT agents impacted the rate of CIOF (p<0.001; Table 1). Higher rate of CIOF was associated with longer CT duration (12w 58.3%, 16-18w 94.5%, 24w 82.1%; p<0.001) and with dose-dense (ddEC-ddD, weekly PM(Cb), intense-dd (idd) EnPC) vs conventional dosed CT (P/nP-EC q3w, P, Cz) (94.5% vs 78.6%; p<0.001). Conclusions: The majority of young women experienced CIOF after CT for EBC. After 2 yrs 62% of the pts returned to premenopausal hormone levels. Age, CT regimen, duration and density influenced the rate of CIOF and should be taken into account when counseling young women who desire to maintain ovarian function. [Table: see text]