scholarly journals Functional Diversity of Chemokines and Chemokine Receptors in Response to Viral Infection of the Central Nervous System

2006 ◽  
pp. 1-27 ◽  
Author(s):  
T. E. Lane ◽  
J. L. Hardison ◽  
K. B. Walsh
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Viral Infection ◽  
Functional Diversity ◽  
Chemokine Receptors ◽  
The Central Nervous System

scholarly journals Seizures and epilepsy secondary to viral infection in the central nervous system

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Peng Zhang ◽  
Yuting Yang ◽  
Jialin Zou ◽  
Xinrui Yang ◽  
Qiankun Liu ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Viral Infection ◽  
The Central Nervous System

TNF-α Microinjection Upregulates Chemokines and Chemokine Receptors in the Central Nervous System Without Inducing Leukocyte Infiltration

2003 ◽  
Vol 23 (8) ◽  
pp. 457-466 ◽  
Author(s):  
Andrzej R. Glabinski ◽  
Bartosz Bielecki ◽  
Pawel Kolodziejski ◽  
Yulong Han ◽  
Krzysztof Selmaj ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chemokine Receptors ◽  
Leukocyte Infiltration ◽  
Tnf Α ◽  
The Central Nervous System

scholarly journals Differential Regulation of Interferon Regulatory Factor (IRF)-7 and IRF-9 Gene Expression in the Central Nervous System during Viral Infection

2005 ◽  
Vol 79 (12) ◽  
pp. 7514-7527 ◽  
Author(s):  
Shalina S. Ousman ◽  
Jianping Wang ◽  
Iain L. Campbell
Keyword(s):  
Gene Expression ◽  
Central Nervous System ◽  
Nervous System ◽  
Viral Infection ◽  
Mononuclear Cells ◽  
Lymphocytic Choriomeningitis ◽  
The Central Nervous System ◽  
Ifn Γ ◽  
The Brain ◽  
Lcmv Infection

ABSTRACT Interferon regulatory factors (IRFs) are a family of transcription factors involved in the regulation of the interferons (IFNs) and other genes that may have an essential role in antiviral defense in the central nervous system, although this is currently not well defined. Therefore, we examined the regulation of IRF gene expression in the brain during viral infection. Several IRF genes (IRF-2, -3, -5, -7, and -9) were expressed at low levels in the brain of uninfected mice. Following intracranial infection with lymphocytic choriomeningitis virus (LCMV), expression of the IRF-7 and IRF-9 genes increased significantly by day 2. IRF-7 and IRF-9 gene expression in the brain was widespread at sites of LCMV infection, with the highest levels in infiltrating mononuclear cells, microglia/macrophages, and neurons. IRF-7 and IRF-9 gene expression was increased in LCMV-infected brain from IFN-γ knockout (KO) but not IFN-α/βR KO animals. In the brain, spleen, and liver or cultured glial and spleen cells, IRF-7 but not IRF-9 gene expression increased with delayed kinetics in the absence of STAT1 but not STAT2 following LCMV infection or IFN-α treatment, respectively. The stimulation of IRF-7 gene expression by IFN-α in glial cell culture was prevented by cycloheximide. Thus, (i) many of the IRF genes were expressed constitutively in the mouse brain; (ii) the IRF-7 and IRF-9 genes were upregulated during viral infection, a process dependent on IFN-α/β but not IFN-γ; and (iii) IRF-7 but not IRF-9 gene expression can be stimulated in a STAT1-independent but STAT2-dependent fashion via unidentified indirect pathways coupled to the activation of the IFN-α/β receptor.

Case Report Simultaneous fungal and viral infection of the central nervous system

1978 ◽  
Vol 276 (1) ◽  
pp. 127 ◽  
Author(s):  
SIGMUND WEITZMAN ◽  
SHELDON KAUFMAN ◽  
EDWARD WOLPOW ◽  
RICHARD C. HINTON ◽  
E. P. RICHARDSON
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Viral Infection ◽  
The Central Nervous System
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