Selection of Multiple SNPs in Case-Control Association Study Using a Discretized Network Flow Approach

2009 ◽  
pp. 211-223 ◽  
Author(s):  
Shantanu Dutt ◽  
Yang Dai ◽  
Huan Ren ◽  
Joel Fontanarosa
Keyword(s):  
Association Study ◽  
Network Flow ◽  
Case Control ◽  
Multiple Snps ◽  
Control Association ◽  
Selection Of

Genetic susceptibility towards breast cancer – First results from the HMBCS case-control association study

2008 ◽  
Vol 68 (S 01) ◽  
Author(s):  
N Bogdanova ◽  
AN Nikolaevna ◽  
JH Karstens ◽  
P Hillemanns ◽  
T Dörk
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Genetic Susceptibility ◽  
Case Control ◽  
First Results ◽  
Control Association

Role of serotonergic-related systems in suicidal behavior: Data from a case–control association study

2011 ◽  
Vol 35 (6) ◽  
pp. 1518-1524 ◽  
Author(s):  
Pilar A. Saiz ◽  
Paz García-Portilla ◽  
Begoña Paredes ◽  
Paul Corcoran ◽  
Celso Arango ◽  
...  
Keyword(s):  
Association Study ◽  
Suicidal Behavior ◽  
Case Control ◽  
Control Association

scholarly journals A case-control association study and family-based expression analysis of the bipolar disorder candidate gene PI4K2B

2009 ◽  
Vol 43 (16) ◽  
pp. 1272-1277 ◽  
Author(s):  
Lorna M. Houlihan ◽  
Andrea Christoforou ◽  
Margaret I. Arbuckle ◽  
Helen S. Torrance ◽  
Susan M. Anderson ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Association Study ◽  
Candidate Gene ◽  
Expression Analysis ◽  
Case Control ◽  
Family Based ◽  
Control Association

Screening of IRF6 Variants in Patients Subjected to Genetic Association Studies for Nonsyndromic Cleft Lip/Palate

2020 ◽  
pp. 105566562098023
Author(s):  
José A. Velázquez-Aragón ◽  
Ariadna González-del Angel ◽  
Miguel A. Alcántara-Ortigoza ◽  
Miriam E. Reyna-Fabián ◽  
Bernardette Estandia-Ortega
Keyword(s):  
Association Study ◽  
Cleft Lip ◽  
Diagnostic Yield ◽  
Association Studies ◽  
Tertiary Care ◽  
Case Series ◽  
Case Control ◽  
Retrospective Case ◽  
Cleft Lip Palate ◽  
Control Association

Objective: To screen for interferon regulatory factor 6 (IRF6) pathogenic variants in patients clinically diagnosed with nonsyndromic cleft lip palate (NSCL/P) and establish the proportion of misdiagnosed Van der Woude syndrome (VWS) cases, which could have biased previous NSCL/P case–control association studies. Design: Retrospective case series. Setting: Tertiary care children’s hospital. Participants: One hundred seventy-two unrelated Mexican patients with NSCL/P, 128 of whom had previously been included in a NSCL/P case–control association study. Main Outcomes Measurements: Sanger sequencing of the 9 IRF6 exons were performed, all variants respect with sequence reference were reported and classified for their pathogenic significance according to the American College of Medical Genetics and Genomics guidelines. Results: Seven percent of cases were familial. No pathogenic variant was identified in IRF6. We identified 12 previously reported benign variants; their frequencies did not significantly differ from those reported for individuals of Mexican ancestry. Three of them were uncommon intronic variants not reported in ClinVar. The rs2235371 and rs2235375 variants, which were previously analyzed in a NSCL/P case–control association study (containing 132 patients, 128 of whom were analyzed herein) did not show discordant association results comparing to the 370 controls from the previous study. Conclusions: The misdiagnosis of IRF6-related VWS as NSCL/P appears to be infrequent in our sample, suggesting that mutational screening of IRF6 would have a low diagnostic yield in patients with NSCL/P. The absence of IRF6 pathogenic alleles could be related to the application of an exhaustive clinical evaluation that discarded the syndromic forms and/or the low proportion of familial cases included.

scholarly journals A gene-based method for detecting gene–gene co-association in a case–control association study

2009 ◽  
Vol 18 (5) ◽  
pp. 582-587 ◽  
Author(s):  
Qianqian Peng ◽  
Jinghua Zhao ◽  
Fuzhong Xue
Keyword(s):  
Association Study ◽  
Case Control ◽  
Control Association

Bipolar disorder susceptibility region on chromosome 3q29 not confirmed in a case–control association study

2011 ◽  
Vol 12 (4) ◽  
pp. 309-315 ◽  
Author(s):  
Alexandra Schosser ◽  
Monika Schloegelhofer ◽  
Karoline Fuchs ◽  
Mirjana Stojanovic ◽  
Nilufar Mossaheb ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Association Study ◽  
Case Control ◽  
Control Association ◽  
Susceptibility Region

scholarly journals A family-based and case-control association study of the NOTCH4 gene and schizophrenia

2002 ◽  
Vol 7 (1) ◽  
pp. 100-103 ◽  
Author(s):  
J B Fan ◽  
J X Tang ◽  
N F Gu ◽  
G Y Feng ◽  
F G Zou ◽  
...  
Keyword(s):  
Association Study ◽  
Case Control ◽  
Family Based ◽  
Control Association
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