Non-invasive monitoring of cortical volume alterations in rat brains using a clinical 3T whole body MRI scanner

2009 ◽  
pp. 406-409
Author(s):  
K. -H. Herrmann ◽  
S. Schmidt ◽  
M. Metzler ◽  
C. Gaser ◽  
O. W. Witte ◽  
...  
Keyword(s):  
Whole Body ◽  
Invasive Monitoring ◽  
Whole Body Mri ◽  
Cortical Volume ◽  
Non Invasive

scholarly journals Unusual presentation of late-onset disseminated staphylococcal sepsis in a preterm infant

2019 ◽  
Vol 12 (3) ◽  
pp. e226325 ◽  
Author(s):  
Shahzad Gul Khattak ◽  
Ian Dady ◽  
Devdeep Mukherjee
Keyword(s):  
Late Onset ◽  
Whole Body ◽  
Whole Body Mri ◽  
Left Hand ◽  
Non Invasive ◽  
Male Baby ◽  
Left Elbow ◽  
The Right ◽  
Panton Valentine Leukocidin ◽  
Rule Out

An ex-30-week gestation, preterm male baby was admitted to a tertiary neonatal unit and noted to have increased ventilator requirements and diagnosed with sepsis. The baby also developed an abscess over the left elbow and over the xiphisternum along with a decrease in movement of the left hand and the right leg. Panton-Valentine leukocidin (PVL)-producing Staphylococcus aureus (SA) was isolated from the blood culture. A whole body MRI showed disseminated abscess with multiple foci in the lung, left elbow and over the xiphisternum. Disseminated sepsis with multiple septic foci has not been previously reported in neonates. We would like to highlight the fact that sepsis due to PVL toxin-producing SA can cause significant morbidity and mortality in neonates. Proper screening should be done to rule out septic foci in neonates. MRI is a good non-invasive investigation to document septic foci in a neonate and rule out multiorgan involvement.

scholarly journals Non-invasive monitoring of arthritis treatment response via targeting of tyrosine-phosphorylated annexin A2 in chondrocytes

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Shaw-Wei D. Tsen ◽  
Luke E. Springer ◽  
Krishna Sharmah Gautam ◽  
Rui Tang ◽  
Kexian Liang ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Treatment Response ◽  
Fluorescence Imaging ◽  
Mouse Models ◽  
Near Infrared ◽  
Early Response ◽  
Annexin A2 ◽  
Whole Body ◽  
Invasive Monitoring ◽  
Non Invasive

Abstract Background The development and optimization of therapies for rheumatoid arthritis (RA) is currently hindered by a lack of methods for early non-invasive monitoring of treatment response. Annexin A2, an inflammation-associated protein whose presence and phosphorylation levels are upregulated in RA, represents a potential molecular target for tracking RA treatment response. Methods LS301, a near-infrared dye-peptide conjugate that selectively targets tyrosine 23-phosphorylated annexin A2 (pANXA2), was evaluated for its utility in monitoring disease progression, remission, and early response to drug treatment in mouse models of RA by fluorescence imaging. The intraarticular distribution and localization of LS301 relative to pANXA2 was determined by histological and immunohistochemical methods. Results In mouse models of spontaneous and serum transfer-induced inflammatory arthritis, intravenously administered LS301 showed selective accumulation in regions of joint pathology including paws, ankles, and knees with positive correlation between fluorescent signal and disease severity by clinical scoring. Whole-body near-infrared imaging with LS301 allowed tracking of spontaneous disease remission and the therapeutic response after dexamethasone treatment. Histological analysis showed preferential accumulation of LS301 within the chondrocytes and articular cartilage in arthritic mice, and colocalization was observed between LS301 and pANXA2 in the joint tissue. Conclusions We demonstrate that fluorescence imaging with LS301 can be used to monitor the progression, remission, and early response to drug treatment in mouse models of RA. Given the ease of detecting LS301 with portable optical imaging devices, the agent may become a useful early treatment response reporter for arthritis diagnosis and drug evaluation.

scholarly journals 2329. Preliminary Safety and Effectiveness of Whole-Body MRI in Pediatric Patients With Persistent Bacteremia or Febrile Illness

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S692-S692
Author(s):  
Edwin Hayes ◽  
Lindsay Miranda ◽  
Anna-Kathryn Burch ◽  
Matthew Marcus ◽  
Helmut Albrecht ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Febrile Illness ◽  
Whole Body ◽  
Whole Body Mri ◽  
Persistent Bacteremia

scholarly journals Diagnostic Value of Whole-Body MRI Short Protocols in Bone Lesion Detection in Multiple Myeloma Patients

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1053
Author(s):  
Davide Ippolito ◽  
Teresa Giandola ◽  
Cesare Maino ◽  
Davide Gandola ◽  
Maria Ragusi ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow Involvement ◽  
Bone Lesion ◽  
Diagnostic Value ◽  
Lesion Detection ◽  
Lower Limbs ◽  
Whole Body ◽  
Bone Lesions ◽  
Whole Body Mri ◽  
Mri Protocol

The aim of the study is to evaluate the effectiveness of short whole-body magnetic resonance imaging (WBMRI) protocols for the overall assessment of bone marrow involvement in patients with multiple myeloma (MM), in comparison with standard whole-body MRI protocol. Patients with biopsy-proven MM, who underwent a WBMRI with full-body coverage (from vertex to feet) were retrospectively enrolled. WBMRI images were independently evaluated by two expert radiologists, in terms of infiltration patterns (normal, focal, diffuse, and combined), according to location (the whole skeleton was divided into six anatomic districts: skull, spine, sternum and ribs, upper limbs, pelvis and proximal two-thirds of the femur, remaining parts of lower limbs) and lytic lesions number (<5, 5–20, and >20). The majority of patients showed focal and combined infiltration patterns with bone lesions predominantly distributed in the spine and pelvis. As skull and lower limbs are less frequently involved by focal bone lesions, excluding them from the standard MRI protocol allows to obtain a shorter protocol, maintaining a good diagnostic value.

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