Cardioprotective Effect of Whole Body Periodic Acceleration in Dystrophic Phenotype mdx Rodent

Duchenne muscular dystrophy (DMD) is characterized by progressive muscle wasting and the development of a dilated cardiomyopathy (DCM), which is the leading cause of death in DMD patients. Despite knowing the cause of DMD, there are currently no therapies which can prevent or reverse its inevitable progression. We have used whole body periodic acceleration (WBPA) as a novel tool to enhance intracellular constitutive nitric oxide (NO) production. WBPA adds small pulses to the circulation to increase pulsatile shear stress, thereby upregulating endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) and subsequently elevating the production of NO. Myocardial cells from dystrophin-deficient 15-month old mdx mice have contractile deficiency, which is associated with elevated concentrations of diastolic Ca2+ ([Ca2+]d), Na+ ([Na+]d), and reactive oxygen species (ROS), increased cell injury, and decreased cell viability. Treating 12-month old mdx mice with WBPA for 3 months reduced cardiomyocyte [Ca2+]d and [Na+]d overload, decreased ROS production, and upregulated expression of the protein utrophin resulting in increased cell viability, reduced cardiomyocyte damage, and improved contractile function compared to untreated mdx mice.

The Zoo of Modes of Convection in Liquids Vibrated along the Direction of the Temperature Gradient

Thermovibrational flow can be seen as a variant of standard thermogravitational convection where steady gravity is replaced by a time-periodic acceleration. As in the parent phenomena, this type of thermal flow is extremely sensitive to the relative directions of the acceleration and the prevailing temperature gradient. Starting from the realization that the overwhelming majority of research has focused on circumstances where the directions of vibrations and of the imposed temperature difference are perpendicular, we concentrate on the companion case in which they are parallel. The increased complexity of this situation essentially stems from the properties that are inherited from the corresponding case with steady gravity, i.e., the standard Rayleigh–Bénard convection. The need to overcome a threshold to induce convection from an initial quiescent state, together with the opposite tendency of acceleration to damp fluid motion when its sign is reversed, causes a variety of possible solutions that can display synchronous, non-synchronous, time-periodic, and multi-frequency responses. Assuming a square cavity as a reference case and a fluid with Pr = 15, we tackle the problem in a numerical framework based on the solution of the governing time-dependent and non-linear equations considering different amplitudes and frequencies of the applied vibrations. The corresponding vibrational Rayleigh number spans the interval from Raω = 104 to Raω = 106. It is shown that a kaleidoscope of possible variants exist whose nature and variety calls for the simultaneous analysis of their temporal and spatial behavior, thermofluid-dynamic (TFD) distortions, and the Nusselt number, in synergy with existing theories on the effect of periodic accelerations on fluid systems.

Engineered spin-orbit interactions in LaAlO3/SrTiO3-based 1D serpentine electron waveguides

The quest to understand, design, and synthesize new forms of quantum matter guides much of contemporary research in condensed matter physics. One-dimensional (1D) electronic systems form the basis for some of the most interesting and exotic phases of quantum matter. Here, we describe a family of quasi-1D nanostructures, based on LaAlO3/SrTiO3 electron waveguides, in which a sinusoidal transverse spatial modulation is imposed. These devices display unique dispersive features in the subband spectra, namely, a sizeable shift (∼7 T) in the spin-dependent subband minima, and fractional conductance plateaus. The first property can be understood as an engineered spin-orbit interaction associated with the periodic acceleration of electrons as they undulate through the nanowire (ballistically), while the second property signifies the presence of enhanced electron-electron scattering in this system. The ability to engineer these interactions in quantum wires contributes to the tool set of a 1D solid-state quantum simulation platform.

The origin of quasi-periodicities during circular ribbon flares

Context. Solar flares with a fan-spine magnetic topology are able to form circular ribbons. A previous study based on Hα line observations of the solar flares on 5 March 2014 revealed a uniform and continuous rotation of the magnetic fan-spine. A preliminary analysis of the flare time profiles revealed quasi-periodic pulsations (QPPs) with similar properties in hard X-rays, Hα, and microwaves. Aims. In this work, we address the question of whether the observed periodicities are related to periodic acceleration of electrons or plasma heating. Methods. We analysed QPPs in the Hα emission from the centre of the fan (inner ribbon R1), a circular ribbon (R2), a remote source (R3), and an elongated ribbon (R4) located between R2 and R3. We used methods of correlation, Fourier, wavelet, and empirical mode decomposition. We compared the QPPs in Hα emission with those in microwave and X-ray emission. Results. We found multi-wavelength QPPs with periods around 150 s, 125 s, and 190 s. The 150 s period is seen to co-exist in Hα, hard X-rays, and microwave emissions, which allowed us to connect it with flare kernels R1 and R2. These kernels spatially coincide with the site of the primary flare energy release. The 125 s period is found in the Hα emission of the elongated ribbon R4 and the microwave emission at 5.7 GHz during the decay phase. The 190 s period is present in the emission during all flare phases in the Hα emission of both the remote source, R3, and the elongated ribbon, R4, in soft X-rays and in microwaves at 4–8 GHz. Conclusions. We connected the dominant 150 s QPPs with the slipping reconnection mechanism occurring in the fan. We suggested that the period of 125 s in the elongated ribbon can be caused by a kink oscillation of the outer spine, connecting the primary reconnection site with the remote footpoint. The period of 190 s is associated with the three-minute sunspot oscillations.

Abstract 195: Chronic Enhancement of Endogenous Nitric Oxide Production via Whole Body Periodic Acceleration (WBPA) Induces Cardioprotection in 15 Months Diabetic Mice

Background: Diabetes mellitus (DM) is a major risk factor for the development of cardiovascular disease. Over time, diabetic patients develop cardiomyopathy, referred to as diabetic cardiomyopathy (DCM). The etiology of DCM in part relates to the duration of hyperglycemia. We have previously shown that type 1 diabetic mice (T1D) have abnormally elevated cardiomyocyte diastolic [Ca 2+ ] d , sodium ([Na + ] d ) after 3 months of diabetes. Whole body periodic acceleration (WBPA) is the motion of the supine body headward to footward in a sinusoidal fashion to induce pulsatile shear stress, increasing expression and phosphorylation of endothelial-derived nitric oxide synthase (eNOS, p-eNOS). We have previously shown that WBPA decreases [Ca 2+ ] d , sodium ([Na + ] d in various models of cardiomyopathy. We hypothesized that WBPA might reverse ion dyshomeostasis in the long term (15-months) hyperglycemia (glucose>250mg/dl) mice. Methods: 15 C57BL/6J (CONT) and diabetic mice (T1D) were randomized to receive WBPA (480 rpm, 1 hr daily for 20 days). Diastolic [Ca 2+ ] d , ([Na + ] d ) (selective microelectrodes), and ROS production (fluorescent) were determined in isolated cardiomyocytes at day 0 and at upon completion of the treatment (day 20). Results: Hyperglycemia produced an increase in [Ca 2+ ] d , [Na + ] d and ROS production in cardiomyocytes. 20 days of WBPA treatment in established DCM significantly decreased [Ca 2+ ] d , [Na + ] d , and ROS production toward normal values. Conclusions: These findings suggest that WBPA may be a therapeutic strategy to reverse ion dyshomeostasis and oxidative stress in a very established(15mos) DCM

Honeybees use their wings for water surface locomotion

Honeybees display a unique biolocomotion strategy at the air–water interface. When water’s adhesive force traps them on the surface, their wetted wings lose ability to generate aerodynamic thrust. However, they adequately locomote, reaching a speed up to 3 body lengths·s−1. Honeybees use their wetted wings as hydrofoils for their water surface propulsion. Their locomotion imparts hydrodynamic momentum to the surrounding water in the form of asymmetric waves and a deeper water jet stream, generating ∼20-μN average thrust. The wing kinematics show that the wing’s stroke plane is skewed, and the wing supinates and pronates during its power and recovery strokes, respectively. The flow under a mechanical model wing mimicking the motion of a bee’s wing further shows that nonzero net horizontal momentum is imparted to the water, demonstrating net thrust. Moreover, a periodic acceleration and deceleration of water are observed, which provides additional forward movement by “recoil locomotion.” Their water surface locomotion by hydrofoiling is kinematically and dynamically distinct from surface skimming [J. H. Marden, M. G. Kramer, Science 266, 427–430 (1994)], water walking [J. W. M. Bush, D. L. Hu, Annu. Rev. Fluid Mech. 38, 339–369 (2006)], and drag-based propulsion [J. Voise, J. Casas, J. R. Soc. Interface 7, 343–352 (2010)]. It is postulated that the ability to self-propel on a water surface may increase the water-foraging honeybee’s survival chances when they fall on the water.