Determining Organization-Specific Process Suitability

2010 ◽  
pp. 26-38 ◽  
Author(s):  
Ove Armbrust
Keyword(s):  
Specific Process

The fate of formaldehyde in sugar manufacture and in products

2015 ◽  
pp. 692-696
Author(s):  
Remi Aubry ◽  
Laurence Gasnot
Keyword(s):  
Sugar Industry ◽  
Common Knowledge ◽  
Microbial Populations ◽  
Optimal Dosage ◽  
Consumer Health ◽  
Microbiological Activity ◽  
Specific Process ◽  
Beet Sugar ◽  
Series Of Experiments

A study was carried out in six beet sugar factories in France during the 2012/13 sugar campaign. The objective was to assess the optimal dosage of formaldehyde solutions at specific process stages and in different existing factory set-ups in order to obtain the desired effect on microbial populations, without interference with the quality of the products. In addition harmlessness regarding consumer health was to be demonstrated. A series of experiments was conducted resulting in new data allowing refreshment of common knowledge and references existing regarding the use of formaldehyde solutions in the sugar industry. The effectiveness and convenience for controlling microbiological activity in beet sugar manufacture was assessed. Formaldehyde reduces sugar losses and protects in-process products without harming their further use, such as for ethanol production.

Improvement of the Thermal Conductivity in 4H-SiC Epitaxial Layer by Introducing Gettering Sites

2008 ◽  
Vol 600-603 ◽  
pp. 525-528
Author(s):  
Laurent Ottaviani ◽  
Michel Kazan ◽  
Pierre M. Masri ◽  
Thierry Sauvage
Keyword(s):  
Thermal Conductivity ◽  
Epitaxial Layer ◽  
Active Area ◽  
Specific Process ◽  
Metal Impurities ◽  
Silicon Based ◽  
Phonon Properties

Metal impurities are known to degrade dramatically the performances of silicon-based devices, even at concentrations as low as 1012 cm-3. A specific process, named proximity gettering, has been optimised by some authors in order to reduce the influence of these impurities [1]. This process consists in the building of a favourable impurity trapping zone in a non-active area of the device, by introducing implantation defects. This paper reports on the application of introducing such gettering sites as an approach to control phonon properties in 4H-SiC epilayer, and increase the thermal conductivity.

scholarly journals V(D)J recombination: signal and coding joint resolution are uncoupled and depend on parallel synapsis of the sites.

1993 ◽  
Vol 13 (3) ◽  
pp. 1363-1370 ◽  
Author(s):  
K M Sheehan ◽  
M R Lieber
Keyword(s):  
Genome Stability ◽  
Lymphoid Cells ◽  
Chromosomal Translocations ◽  
Synaptic Inhibition ◽  
Site Specific ◽  
Coding Sequences ◽  
Specific Process ◽  
A Site ◽  
Joint Resolution

V(D)J recombination in lymphoid cells is a site-specific process in which the activity of the recombinase enzyme is targeted to signal sequences flanking the coding elements of antigen receptor genes. The order of the steps in this reaction and their mechanistic interdependence are important to the understanding of how the reaction fails and thereby contributes to genomic instability in lymphoid cells. The products of the normal reaction are recombinant joints linking the coding sequences of the receptor genes and, reciprocally, the signal ends. Extrachromosomal substrate molecules were modified to inhibit the physical synapsis of the recombination signals. In this way, it has been possible to assess how inhibiting the formation of one joint affects the resolution efficiency of the other. Our results indicate that signal joint and coding joint formation are resolved independently in that they can be uncoupled from each other. We also find that signal synapsis is critical for the generation of recombinant products, which greatly restricts the degree of potential single-site cutting that might otherwise occur in the genome. Finally, inversion substrates manifest synaptic inhibition at much longer distances than do deletion substrates, suggesting that a parallel rather than an antiparallel alignment of the signals is required during synapsis. These observations are important for understanding the interaction of V(D)J signals with the recombinase. Moreover, the role of signal synapsis in regulating recombinase activity has significant implications for genome stability regarding the frequency of recombinase-mediated chromosomal translocations.

Antimalarial activity of the bisquinoline trans-N1,N2-bis (7-chloroquinolin-4-yl)cyclohexane-1,2-diamine: comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737.

1997 ◽  
Vol 41 (3) ◽  
pp. 677-686 ◽  
Author(s):  
R G Ridley ◽  
H Matile ◽  
C Jaquet ◽  
A Dorn ◽  
W Hofheinz ◽  
...  
Keyword(s):  
Antimalarial Activity ◽  
Ex Vivo ◽  
The Other ◽  
Parasite Resistance ◽  
Curative Effect ◽  
Specific Process ◽  
Terminal Half Life ◽  
Detailed Evaluation ◽  
Oral Doses

The S,S enantiomer of the bisquinoline trans-N1,N2-bis(7-chloroquinolin-4-yl)cyclohexane-1,2-diamine, Ro 47-7737, is significantly more potent against chloroquine-resistant Plasmodium falciparum than the R,R enantiomer and the previously described racemate. Both the enantiomers and the racemate are more potent inhibitors of heme polymerization than chloroquine, and their activities are probably mediated by inhibition of this parasite-specific process. The S,S enantiomer, Ro 47-7737, was studied in more detail and proved to be a potent antimalarial in the treatment of P. vivax ex vivo and P. berghei in vivo. Its suppression of P. berghei growth in a mouse model (50% effective dose, 2.3 mg/kg of body weight) was equal to that of chloroquine and mefloquine, and Ro 47-7737 was found to be more potent than these two drugs in the Rane test, in which the curative effect of a single dose is monitored. The dose at which 50% of animals were permanently cured (34 mg/kg) was markedly superior to those of chloroquine (285 mg/kg) and mefloquine (> 250 mg/kg). When administered orally at 50 mg/kg, Ro 47-7737 also showed a faster clearance of parasites than either chloroquine or mefloquine, and unlike the other two compounds, Ro 47-7737 showed no recrudescence. In a study to compare prophylactic efficacies of oral doses of 50 mg/kg, Ro 47-7737 provided protection for 14 days compared to 3 days for mefloquine and 1 day for chloroquine. The good curative and prophylactic properties of the compound can be explained in part by its long terminal half-life. The ability to generate parasite resistance to Ro 47-7737 was also assessed. With a rodent model, resistance could be generated over eight passages. This rate of resistance generation is comparable to that of mefloquine, which has proved to be an effective antimalarial for many years. Toxicity liabilities, however, ruled out this compound as a candidate for drug development.

scholarly journals Communicative Competence as a Subjective Determinant: Globalization and Personal Aspects

2017 ◽  
Vol 4 (1) ◽  
pp. 48-52
Author(s):  
Tetyana Pantiuk ◽  
Mykola Pantiuk ◽  
Iryna Voloshanska ◽  
Zoriana Burkovska
Keyword(s):  
Social Determinants ◽  
Communicative Competence ◽  
Specific Process ◽  
Definite Problem ◽  
Educational Psychological

The content and the specific process of communicative competence formation of the individuality are justified in the article; social determinants that determine the need to improve this process and harmonization with the needs of society and individuality are defined. The educational, psychological, philosophical sources are analysed, the main directions of research on definite problem are characterized. The essence of communicative competence as the educational phenomenon is found; the importance of communicative competence in today's conditions is proved. The attention is paid to the main principles and methods of communicative competence of the individuality  

scholarly journals Back-end porting of FT_MX based on LLVM compilation architecture

2021 ◽  
Vol 336 ◽  
pp. 04018
Author(s):  
Ping Deng ◽  
Xiaolong Zhu ◽  
Haiyan Sun ◽  
Yi Ren
Keyword(s):  
Open Source ◽  
High Performance ◽  
Instruction Set ◽  
University Of Illinois ◽  
Specific Process ◽  
Defense Technology ◽  
Migration Mechanism ◽  
National University ◽  
Compiler Framework ◽  
The University

The processor FT_MX is a high-performance chip independently developed by the National University of Defense Technology, with an innovative architecture and instruction set. LLVM architecture is a widely used and efficient open source compiler framework initiated by the University of Illinois. This paper introduces the basic architecture and functions of LLVM, analyzes the back-end migration mechanism of the architecture in detail, and gives the specific process of implementing FT_MX back-end migration, and realizes the support of LLVM architecture to the back-end of FT_MX processor.

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