Renal Histology in Hypertensive Diabetics

Introduction/Aims: Hydrogen sulfide (H2S) is considered to be the third most important endogenous gasotransmitter in organisms. GYY4137 is a long-acting donor for H2S, a gas transmitter that has been shown to prevent multi-organ damage in animal studies. We previously reported the effect of GYY4137 on cardiac ischaemia reperfusion injury (IRI) in diabetic mice. However, the role and mechanism of GYY4137 in renal IRI are poorly understood. The aims of this study were to determine whether GYY4137 can effectively alleviate the injury induced by renal ischaemia reperfusion and to explore its possible mechanism. Methods: Mice received right nephrectomy and clipping of the left renal pedicle for 45 min. GYY4137 was administered by intraperitoneal injection for 2 consecutive days before the operation. The model of hypoxia/reoxygenation injury was established in HK-2 cells, which were pre-treated with or without GYY4137. Renal histology, function, apoptosis, and oxidative stress were measured. Western blot was used to measure the target protein after renal IRI. Results: The results indicated that GYY4137 had a clear protective effect on renal IRI as reflected by the attenuation of renal dysfunction, renal tubule injury, and apoptosis. Moreover, GYY4137 remarkably reduced renal IRI-induced oxidative stress. GYY4137 significantly elevated the nuclear translocation of nuclear factor-erythroid-2-related factor 2 (Nrf2) and the expression of antioxidant enzymes regulated by Nrf2, including SOD, HO-1, and NQO-1. Conclusions: GYY4137 alleviates ischaemia reperfusion-induced renal injury through activating the antioxidant effect mediated by Nrf2 signalling.

Download Full-text

POS-238 The evolving spectrum of renal histology in HIV positive patients in South Africa in the antiretroviral and tuberculosis era

Kidney International Reports ◽

10.1016/j.ekir.2021.03.252 ◽

2021 ◽

Vol 6 (4) ◽

pp. S100-S101

Author(s):

N. Wearne ◽

B. Davidson ◽

E. Jones ◽

A. Omar ◽

C. Cunningham ◽

...

Keyword(s):

South Africa ◽

Hiv Positive ◽

Renal Histology

Download Full-text

Antihypertensive Effect of Thymectomy in Lyon Hypertensive Rats Vascular Reactivity, Renal Histology, and Sodium Excretion*

American Journal of Hypertension ◽

10.1016/0895-7061(95)00255-n ◽

1996 ◽

Keyword(s):

Sodium Excretion ◽

Vascular Reactivity ◽

Antihypertensive Effect ◽

Hypertensive Rats ◽

Renal Histology

Download Full-text

Association of coexisting anti-ribosomal P and anti-dsDNA antibodies with histology and renal prognosis in lupus nephritis patients

Lupus ◽

10.1177/0961203320983906 ◽

2021 ◽

pp. 096120332098390

Author(s):

Ayako Wakamatsu ◽

Hiroe Sato ◽

Yoshikatsu Kaneko ◽

Takamasa Cho ◽

Yumi Ito ◽

...

Keyword(s):

Lupus Nephritis ◽

Lupus Erythematosus ◽

Renal Outcome ◽

Class V ◽

Double Stranded Dna ◽

Number Of Patients ◽

Renal Histology ◽

Renal Prognosis ◽

Incidence Of Ckd ◽

Ribosomal P

Objectives Anti-ribosomal P protein autoantibodies (anti-P) specifically develop in patients with systemic lupus erythematosus. Associations of anti-P with lupus nephritis (LN) histological subclass and renal outcome remain inconclusive. We sought to determine the association of anti-P and anti-double-stranded DNA antibody (anti-dsDNA) with renal histology and prognosis in LN patients. Methods Thirty-four patients with LN, having undergone kidney biopsy, were included. The 2018 revised ISN/RPS classification system was used for pathophysiological evaluation. Chronic kidney disease (CKD) was defined as an estimated glomerular filtration rate < 60 mL/min/1.73 m2 for > 3 months. Results Six patients (17.6%) were positive for anti-P and 26 (76.5%) for anti-dsDNA. Among the six patients with anti-P, one did not have anti-dsDNA, but did have anti-Sm antibody, and showed a histological subtype of class V. This patient maintained good renal function for over 14 years. The remaining five patients, who had both anti-P and anti-dsDNA, exhibited proliferative nephritis and were associated with prolonged hypocomplementemia, and the incidence of CKD did not differ from patients without anti-P. Conclusion Although this study included a small number of patients, the results indicated that histology class and renal prognosis associated with anti-P depend on the coexistence of anti-dsDNA. Further studies with a large number of patients are required to confirm this conclusion.

Download Full-text

Correction to: Renal histology across the stages of chronic kidney disease

Journal of Nephrology ◽

10.1007/s40620-021-01059-1 ◽

2021 ◽

Author(s):

Francesco Trevisani ◽

Federico Di Marco ◽

Umberto Capitanio ◽

Giacomo Dell’Antonio ◽

Alessandra Cinque ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Renal Histology

Download Full-text

Protective Effects of Carbon Dots Derived from Phellodendri Chinensis Cortex Carbonisata against Deinagkistrodon acutus Venom-Induced Acute Kidney Injury

Nanoscale Research Letters ◽

10.1186/s11671-019-3198-1 ◽

2019 ◽

Vol 14 (1) ◽

Cited By ~ 2

Author(s):

Meiling Zhang ◽

Jinjun Cheng ◽

Ziwei Sun ◽

Hui Kong ◽

Yue Zhang ◽

...

Keyword(s):

Acute Kidney Injury ◽

Carbon Dots ◽

Biomedical Applications ◽

Abdominal Cavity ◽

Kidney Injury ◽

Protective Effects ◽

Inflammatory Reactions ◽

Chemotactic Protein ◽

Renal Histology ◽

Deinagkistrodon Acutus

Abstract Background As an emerging nanomaterial, carbon dots (CDs) have been the focus of tremendous attention for biomedical applications. However, little information is available on their bioactivity of inhibiting acute kidney injury (AKI) induced by snake venom. Methods This study reports the development of a green, one-step pyrolysis process to synthesize CDs using Phellodendri Chinensis Cortex (PCC) as the sole precursor, and their potential application as a protectant against Deinagkistrodon acutus (D. acutus) venom-induced AKI was investigated for the first time. The AKI model was established by injecting D. acutus venom into the abdominal cavity of mice and the potential protective effects of PCC Carbonisata-CDs (PCCC-CDs) on renal abnormalities including dysfunction, inflammatory reactions, tissue damage, and thrombocytopenia at six time points (1, 3, and 12 h, and 1, 2, and 5 days) were investigated. Results These results demonstrated that PCCC-CDs significantly inhibited the kidney dysfunction (reduced serum creatinine (SCR), blood urea nitrogen (BUN), urinary total protein (UTP), and microalbuminuria (MALB) concentrations) and the production of chemoattractant (monocyte chemotactic protein 1 (MCP-1)), proinflammatory cytokines (interleukin (IL)-1β), and anti-inflammatory cytokine (IL-10) in response to intraperitoneal injection of D. acutus venom. The beneficial effect of PCCC-CDs on the envenomed mice was similar to that on the change in renal histology and thrombocytopenia. Conclusions These results demonstrated the remarkable protective effects of PCCC-CDs against AKI induced by D. acutus venom, which would not only broaden the biomedical applications of CDs but also provide a potential target for the development of new therapeutic drugs for AKI induced by D. acutus snakebite envenomation.

Download Full-text

Offspring’s hydromineral adaptive responses to maternal undernutrition during lactation

Journal of Developmental Origins of Health and Disease ◽

10.1017/s204017441500135x ◽

2015 ◽

Vol 6 (6) ◽

pp. 520-529 ◽

Cited By ~ 3

Author(s):

P. Nuñez ◽

J. Arguelles ◽

C. Perillan

Keyword(s):

Salt Intake ◽

Maternal Diet ◽

Plasma Osmolality ◽

Control Mechanisms ◽

Lactation Period ◽

Adaptive Responses ◽

Long Term Effects ◽

Molecular Alterations ◽

Maternal Undernutrition ◽

Renal Histology

Early development, throughout gestation and lactation, represents a period of extreme vulnerability during which susceptibility to later metabolic and cardiovascular injuries increases. Maternal diet is a major determinant of the foetal and newborn developmental environment; maternal undernutrition may result in adaptive responses leading to structural and molecular alterations in various organs and tissues, such as the brain and kidney. New nephron anlages appear in the renal cortex up to postnatal day 4 and the last anlages to be formed develop into functional nephrons by postnatal day 10 in rodents. We used a model of undernutrition in rat dams that were food-restricted during the first half of the lactation period in order to study the long-term effects of maternal diet on renal development, behaviour and neural hydromineral control mechanisms. The study showed that after 40% food restriction in maternal dietary intake, the dipsogenic responses for both water and salt intake were not altered; Fos expression in brain areas investigated involved in hydromineral homeostasis control was always higher in the offspring in response to isoproterenol. This was accompanied by normal plasma osmolality changes and typical renal histology. These results suggest that the mechanisms for the control of hydromineral balance were unaffected in the offspring of these 40% food-restricted mothers. Undernutrition of the pups may not be as drastic as suggested by dams’ restriction.

Download Full-text