Cell Biology of Insulin Action on Glucose Transport and Its Perturbation in Diabetes Mellitus

1989 ◽  
pp. 94-106
Author(s):  
B. B. Kahn ◽  
S. W. Cushman
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Transport ◽  
Cell Biology ◽  
Insulin Action

Cell biology of insulin action on glucose transport

1994 ◽  
Vol 1 ◽  
pp. 36
Author(s):  
S.W. Cushman ◽  
S. Satoh ◽  
S.J. Vannucci ◽  
I.A. Simpson ◽  
G.D. Holman
Keyword(s):  
Glucose Transport ◽  
Cell Biology ◽  
Insulin Action

A Critical Review on Madhumeha (Diabetes Mellitus) with its Preventive Approach

2017 ◽  
Vol 2 (05) ◽  
Author(s):  
Anagha Gosavi ◽  
Ram V. Ramekar
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Protein Metabolism ◽  
Insulin Action ◽  
Preventive Measures ◽  
Sweet Taste ◽  
Whole Body ◽  
Appropriate Use ◽  
Chronic Hyperglycemia ◽  
Therapeutic Measures

Prameha is disease of Mutravaha Srotasa having Kapha dominancy which can be correlated with diabetes mellitus. The term diabetes mellitus describes a metabolic disorder of multiple etiologies characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. Madhumeha is considered as a subtype under the Vatika type of Prameha and it is characterized by passage of urine with sweet taste like honey along with sweetness of whole body. With appropriate use of Ayurvedic preventive measures such as Dincharya, Ritucharya, Aharvidhi and therapeutic measures Madhumeha (DM) can be prevented.

scholarly journals Effect of Insulin on Proximal Tubules Handling of Glucose: A Systematic Review

2020 ◽  
Vol 2020 ◽  
pp. 1-17 ◽  
Author(s):  
Ricardo Pereira-Moreira ◽  
Elza Muscelli
Keyword(s):  
Glucose Transport ◽  
Insulin Action ◽  
Current Knowledge ◽  
Sglt2 Inhibitor ◽  
Proximal Tubules ◽  
Human Studies ◽  
Glucose Disposal ◽  
Diabetic Patients ◽  
Insulin Effect ◽  
Renal Gluconeogenesis

Renal proximal tubules reabsorb glucose from the glomerular filtrate and release it back into the circulation. Modulation of glomerular filtration and renal glucose disposal are some of the insulin actions, but little is known about a possible insulin effect on tubular glucose reabsorption. This review is aimed at synthesizing the current knowledge about insulin action on glucose handling by proximal tubules. Method. A systematic article selection from Medline (PubMed) and Embase between 2008 and 2019. 180 selected articles were clustered into topics (renal insulin handling, proximal tubule glucose transport, renal gluconeogenesis, and renal insulin resistance). Summary of Results. Insulin upregulates its renal uptake and degradation, and there is probably a renal site-specific insulin action and resistance; studies in diabetic animal models suggest that insulin increases renal SGLT2 protein content; in vivo human studies on glucose transport are few, and results of glucose transporter protein and mRNA contents are conflicting in human kidney biopsies; maximum renal glucose reabsorptive capacity is higher in diabetic patients than in healthy subjects; glucose stimulates SGLT1, SGLT2, and GLUT2 in renal cell cultures while insulin raises SGLT2 protein availability and activity and seems to directly inhibit the SGLT1 activity despite it activating this transporter indirectly. Besides, insulin regulates SGLT2 inhibitor bioavailability, inhibits renal gluconeogenesis, and interferes with Na+K+ATPase activity impacting on glucose transport. Conclusion. Available data points to an important insulin participation in renal glucose handling, including tubular glucose transport, but human studies with reproducible and comparable method are still needed.

Insulin Action on Glucose Transport in Isolated Skeletal Muscle from Patients with Liver Cirrhosis

1994 ◽  
Vol 29 (1) ◽  
pp. 71-76 ◽  
Author(s):  
U. Johansson ◽  
L. S. Eriksson ◽  
D. Galuska ◽  
J. R. Zierath ◽  
H. Wallberg-henriksson
Keyword(s):  
Skeletal Muscle ◽  
Liver Cirrhosis ◽  
Glucose Transport ◽  
Insulin Action

Adenosine effects upon insulin action on lipolysis and glucose transport in human adipocytes

1995 ◽  
Vol 144 (2) ◽  
pp. 147-151 ◽  
Author(s):  
Lesley Heseltine ◽  
Judith M. Webster ◽  
Roy Taylor
Keyword(s):  
Glucose Transport ◽  
Insulin Action ◽  
Human Adipocytes

Insulin Binding and Glucose Transport in Adipocytes in Neonatal Streptozocin-Injected Rat Model of Diabetes Mellitus

Diabetes ◽  
1987 ◽  
Vol 36 (5) ◽  
pp. 654-660 ◽  
Author(s):  
I. G. Fantus ◽  
R. Chayoth ◽  
L. O'Dea ◽  
E. B. Marliss ◽  
J.-F. Yale ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Transport ◽  
Rat Model ◽  
Insulin Binding
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