Genetic Regulation of Sporulation in the Fungus Aspergillus nidulans

Development ◽  
1992 ◽  
pp. 103-120 ◽  
Author(s):  
A. John Clutterbuck ◽  
William E. Timberlake
Keyword(s):  
Aspergillus Nidulans ◽  
Genetic Regulation

Genetic Regulation of Aryl Sulphatases in Aspergillus nidulans

1966 ◽  
Vol 31 (0) ◽  
pp. 381-382 ◽  
Author(s):  
O. Siddiqi ◽  
B. N. Apte ◽  
M. P. Pitale
Keyword(s):  
Aspergillus Nidulans ◽  
Genetic Regulation

scholarly journals UrdA Controls Secondary Metabolite Production and the Balance between Asexual and Sexual Development in Aspergillus nidulans

Genes ◽  
2018 ◽  
Vol 9 (12) ◽  
pp. 570 ◽  
Author(s):  
Sandesh Pandit ◽  
Jessica Lohmar ◽  
Shawana Ahmed ◽  
Oier Etxebeste ◽  
Eduardo Espeso ◽  
...  
Keyword(s):  
Secondary Metabolism ◽  
Aspergillus Nidulans ◽  
Sexual Development ◽  
Plant Pathogens ◽  
Genetic Regulation ◽  
Sequence Divergence ◽  
Toxin Production ◽  
Human Pathogens ◽  
Wild Type ◽  
Morphological Alterations

The genus Aspergillus includes important plant pathogens, opportunistic human pathogens and mycotoxigenic fungi. In these organisms, secondary metabolism and morphogenesis are subject to a complex genetic regulation. Here we functionally characterized urdA, a gene encoding a putative helix-loop-helix (HLH)-type regulator in the model fungus Aspergillus nidulans. urdA governs asexual and sexual development in strains with a wild-type veA background; absence of urdA resulted in severe morphological alterations, with a significant reduction of conidial production and an increase in cleistothecial formation, even in the presence of light, a repressor of sex. The positive effect of urdA on conidiation is mediated by the central developmental pathway (CDP). However, brlA overexpression was not sufficient to restore wild-type conidiation in the ΔurdA strain. Heterologous complementation of ΔurdA with the putative Aspergillus flavus urdA homolog also failed to rescue conidiation wild-type levels, indicating that both genes perform different functions, probably reflected by key sequence divergence. UrdA also represses sterigmatocystin (ST) toxin production in the presence of light by affecting the expression of aflR, the activator of the ST gene cluster. Furthermore, UrdA regulates the production of several unknown secondary metabolites, revealing a broader regulatory scope. Interestingly, UrdA affects the abundance and distribution of the VeA protein in hyphae, and our genetics studies indicated that veA appears epistatic to urdA regarding ST production. However, the distinct fluffy phenotype of the ΔurdAΔveA double mutant suggests that both regulators conduct independent developmental roles. Overall, these results suggest that UrdA plays a pivotal role in the coordination of development and secondary metabolism in A. nidulans.

scholarly journals Genetic Regulation of the Quinic Acid Utilization (QUT) Gene Cluster in Aspergillus nidulans

Microbiology ◽  
1988 ◽  
Vol 134 (2) ◽  
pp. 347-358 ◽  
Author(s):  
S. GRANT ◽  
C. F. ROBERTS ◽  
H. LAMB ◽  
M. STOUT ◽  
A. R. HAWKINS
Keyword(s):  
Aspergillus Nidulans ◽  
Gene Cluster ◽  
Genetic Regulation ◽  
Quinic Acid

scholarly journals Genetic Regulation of Isocitrate Lyase Activity in Aspergillus nidulans

Microbiology ◽  
1980 ◽  
Vol 120 (1) ◽  
pp. 67-84 ◽  
Author(s):  
W. MCCULLOUGH ◽  
C. F. ROBERTS
Keyword(s):  
Aspergillus Nidulans ◽  
Isocitrate Lyase ◽  
Genetic Regulation ◽  
Lyase Activity

Genetic regulation of development in Aspergillus nidulans

1988 ◽  
Vol 4 (6) ◽  
pp. 162-169 ◽  
Author(s):  
W TIMBERLAKE ◽  
M MARSHALL
Keyword(s):  
Aspergillus Nidulans ◽  
Genetic Regulation

Phenotypic dissection of bone mineral density facilitates the identification of skeletal site specificity on the genetic regulation of bone

2013 ◽  
Author(s):  
John P Kemp ◽  
Carolina Medina-Gomez ◽  
Karol Estrada ◽  
Denise Heppe ◽  
Carola Zillikens ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Genetic Regulation ◽  
Site Specificity ◽  
Mineral Density ◽  
Skeletal Site

Phenotypic dissection of bone mineral density facilitates the identification of skeletal site specificity on the genetic regulation of bone

2013 ◽  
Author(s):  
P Kemp John ◽  
Medina-Gomez Carolina ◽  
Estrada Karol ◽  
H M Heppe Denise ◽  
M Zillikens Carola ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Genetic Regulation ◽  
Site Specificity ◽  
Mineral Density ◽  
Skeletal Site

Principal component-derived bone density phenotypes and genetic regulation of the pediatric skeleton

2017 ◽  
Author(s):  
Jonathan Mitchell ◽  
Alessandra Chesi ◽  
Shana McCormack ◽  
Diana Cousminer ◽  
Heidi Kalkwarf ◽  
...  
Keyword(s):  
Bone Density ◽  
Genetic Regulation ◽  
Principal Component
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