Peritoneal Permeability in Continuous Ambulatory Peritoneal Dialysis After the Correction of Anemia by Erythropoietin

Objective To examine the elimination of iomeprol, its safety in clinical use, and its peritoneal permeability in continuous ambulatory peritoneal dialysis (CAPD) patients with variable degrees of residual renal function (RRF). Design A nonrandomized comparison study. Setting Hospitalized patients in CAPD unit of Chikuho and University Hospitals. Participants Fourteen patients treated by CAPD and 6 by hemodialysis (HD). Interventions Total dialysate, blood, and 24-hour urine collections were obtained for 4 consecutive days after the administration of iomeprol. A peritoneal equilibration test was performed just before and after the administration of iomeprol. Measurements Iomeprol (iodine) concentration was measured. Residual renal function was estimated as the mean of renal creatinine and urea clearances. Dialysate-to-plasma ratios (D/P) of creatinine and iomeprol were also determined. Results In all CAPD patients, plasma iomeprol clearance was markedly slow, with a biological half-life ( T1/2) of over 32 hours. However, no patients suffered from any adverse effects, and over 80% of plasma iomeprol was eliminated during the 4-hour HD. The plasma iomeprol elimination rate was significantly higher from 4 hours after the iomeprol administration in CAPD patients with RRF [mean estimated creatinine clearance (CCr) 3.8 mL/min, n = 7] compared to the remaining patients (mean estimated CCr 0.6 mL/min, n = 7); however, T1/2 in patients with RRF was over 24 hours. D/P creatinine was significantly correlated with D/P iomeprol, and peritoneal iomeprol permeability may depend on an individual's peritoneal solute transport properties. Conclusions A prolonged elimination rate of iomeprol was documented in our CAPD patients both with and without RRF. A HD procedure or intensive peritoneal dialysis just after the use of iomeprol may be advisable to promptly remove circulating iomeprol.

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Increased peritoneal permeability in patients with peritonitis undergoing continuous ambulatory peritoneal dialysis

European Journal of Clinical Pharmacology ◽

10.1007/bf00609690 ◽

1985 ◽

Vol 28 (2) ◽

pp. 187-191 ◽

Cited By ~ 15

Author(s):

M. E. McIntosh ◽

W. G. J. Smith ◽

B. J. R. Junor ◽

G. Forrest ◽

M. J. Brodie

Keyword(s):

Peritoneal Dialysis ◽

Continuous Ambulatory Peritoneal Dialysis ◽

Peritoneal Permeability

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Intraperitoneal Administration of Phospha Tidylcholine Improves Ul Trafil Tration in Continuous Ambulatory Peritoneal Dialysis Patients

Peritoneal Dialysis International ◽

10.1177/089686089201200405 ◽

1992 ◽

Vol 12 (4) ◽

pp. 359-364 ◽

Cited By ~ 28

Author(s):

Genevieve Krack ◽

Giusto Viglino ◽

Pier Luigi Cavalli ◽

Carmen Gandolfo ◽

Giuseppe Magliano ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Continuous Ambulatory Peritoneal Dialysis ◽

Driving Force ◽

Clinical Evidence ◽

Intraperitoneal Administration ◽

Glucose Load ◽

Dialysis Patients ◽

Peritoneal Equilibration Test ◽

Dialysis Solution ◽

Peritoneal Permeability

Reports in the literature have linked a low phosphatidylcholine content in continuous ambulatory peritoneal dialysis {CAPD) effluent to ultrafiltration loss. Clinical evidence suggests that adding phosphatidylcholine to the dialysis solution enhances ultrafiltration. A clinical study has been designed to clarify the effect of phosphatidylcholine on ultrafiltration in CAPD patients with normal ultrafiltration. A weekly measurement of the peritoneal equilibration test was conducted per patient in the hospital. A comparison between the control dialysis solution {three-week period) and the phosphatidylcholine premixed solution {three-week period) was performed on a total of 12 patients. This study shows that a phosphatidylcholine premixed dialysis solution significantly enhances ultrafiltration. Since ultrafiltration per osmotic driving force (mUg glucose) is enhanced, the patient's glucose load per day is reduced to achieve equal ultrafiltration. In the presence of phosphatidylcholine, peritoneal permeability remained unchanged, as indicated by membrane transport characteristics. No side effects were observed.

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Cytokine Patterns in the Effluent of Continuous Ambulatory Peritoneal Dialysis: Relationship to Peritoneal Permeability

Blood Purification ◽

10.1159/000170263 ◽

1996 ◽

Vol 14 (2) ◽

pp. 198-216 ◽

Cited By ~ 34

Author(s):

Désirée Zemel ◽

Raymond T. Krediet

Keyword(s):

Peritoneal Dialysis ◽

Continuous Ambulatory Peritoneal Dialysis ◽

Peritoneal Permeability

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Peritoneal Permeability to Proteins in Diabetic and Non-Diabetic Continuous Ambulatory Peritoneal Dialysis Patients

Nephron ◽

10.1159/000183652 ◽

1986 ◽

Vol 42 (2) ◽

pp. 133-140 ◽

Cited By ~ 79

Author(s):

R.T. Krediet ◽

F.M.J. Zuyderhoudt ◽

E.W. Boeschoten ◽

L. Arisz

Keyword(s):

Peritoneal Dialysis ◽

Continuous Ambulatory Peritoneal Dialysis ◽

Dialysis Patients ◽

Peritoneal Permeability

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Comparison of patient survival and technique survival between continuous ambulatory peritoneal dialysis and automated peritoneal dialysis

Peritoneal Dialysis International ◽

10.1177/0896860820942987 ◽

2020 ◽

Vol 40 (6) ◽

pp. 563-572

Author(s):

I-Kuan Wang ◽

Tung-Min Yu ◽

Tzung-Hai Yen ◽

Shih-Yi Lin ◽

Chia-Ling Chang ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Continuous Ambulatory Peritoneal Dialysis ◽

Lower Risk ◽

Patient Survival ◽

Diabetic Patients ◽

Automated Peritoneal Dialysis ◽

Technique Survival ◽

Peritoneal Permeability ◽

Male Patients ◽

Technique Failure

Background: This retrospective cohort study compared patient survival and technique survival between patients on continuous ambulatory peritoneal dialysis (CAPD) and automated peritoneal dialysis (APD) using recent data at a single tertiary medical center in Taiwan. Methods: From medical records, we identified incident 459 CAPD patients and 266 APD patients on dialysis for at least 90 days and aged more than 18 years to estimate mortality and technique failure rates, and related hazard ratio (HR) and 95% confidence interval (CI) from 2007 to 2018. Results: There were more women (52.3%) in the CAPD group, whereas patients in the APD group were younger. Compared to CAPD patients, APD patients had a lower mortality rate (2.83 vs. 5.79 per 100 person-years) with an adjusted HR of 0.69 (95% CI = 0.47–1.02), and a lower technique failure rate (9.70 vs. 17.52 per 100 person-years) with an adjusted HR of 0.65 (95% CI = 0.51–0.83). Further subgroup analyses revealed that, compared to CAPD, APD was associated with a significant lower risk of technique failure in male patients, patients aged 50–65 years, diabetic patients, patients without cardiovascular disease (CVD), patients with higher peritoneal permeability, or patients initiating PD in an earlier era. Conclusions: The mortality risk was not significant between CAPD and APD patients. APD is associated with a lower risk of technique failure than CAPD, particularly for male patients, and patients aged 50–65 years, with diabetes, without CVD, with high or high average peritoneal permeability, or initiating PD in an earlier era.

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Can the Risk of Peritonitis be Predicted for New Continuous Ambulatory Peritoneal Dialysis (CAPD) Patients?

Peritoneal Dialysis International ◽

10.1177/089686088900900114 ◽

1989 ◽

Vol 9 (1) ◽

pp. 69-72 ◽

Cited By ~ 9

Author(s):

Gerald A. Coles ◽

Susan J. Minors ◽

Jeffrey K. Horton ◽

Richard Fifield ◽

Malcolm Davies

Keyword(s):

At Risk ◽

Peritoneal Dialysis ◽

Continuous Ambulatory Peritoneal Dialysis ◽

Significant Fall ◽

Peritoneal Permeability

Serum and overnight dialysate samples were obtained from 36 adult uraemic patients at the end of their continuous ambulatory peritoneal dialysis (CAPD) training. The samples were analysed for albumin, IgG, C3, and antistaphylococcal peptidoglycan antibody. None of the dialysate measurements correlated with the risk of peritonitis during up to one year's CAPD treatment. Nineteen of the 36 patients were retested 6 to 20 months after starting CAPD. There were significant rises in serum C3 ( p < 0.02) and albumin ( p < 0.001) and a significant fall in dialysate IgG ( p < 0.02). Eight further patients were sampled at the end of training and three weeks later. They had a significant fall in dialysate IgG ( p < 0.05). During CAPD training peritoneal permeability appears to be transiently increased. Analysis of overnight dialysate samples during training does not allow prediction of those at risk of subsequent peritonitis.

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Scanning Electron Microscopy of Staphylococcus Epidermidis Adherence to Continuous Ambulatory Peritoneal Dialysis Catheters

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100119429 ◽

1985 ◽

Vol 43 ◽

pp. 520-521

Author(s):

William J. Lamoreaux ◽

David L. Smalley ◽

Larry M. Baddour ◽

Alfred P. Kraus

Keyword(s):

Electron Microscopy ◽

Scanning Electron Microscopy ◽

Peritoneal Dialysis ◽

Continuous Ambulatory Peritoneal Dialysis ◽

Staphylococcus Epidermidis ◽

Sterile Saline ◽

Intravascular Devices ◽

Capd Patient ◽

Scanning Electron

Infections associated with the use of intravascular devices have been documented and have been reported to be related to duration of catheter usage. Recently, Eaton et al. reported that Staphylococcus epidermidis may attach to silastic catheters used in continuous ambulatory peritoneal dialysis (CAPD) treatment. The following study presents findings using scanning electron microscopy (SEM) of S. epidermidis adherence to silastic catheters in an in vitro model. In addition, sections of polyvinyl chloride (PVC) dialysis bags were also evaluated by SEM.The S. epidermidis strain RP62A which had been obtained in a previous outbreak of coagulase-negative staphylococcal sepsis at local hospitals was used in these experiments. The strain produced surface slime on exposure to glucose, whereas a nonadherent variant RP62A-NA, which was also used in these studies, failed to produce slime. Strains were grown overnight on blood agar plates at 37°C, harvested from the surface and resuspended in sterile saline (0.85%), centrifuged (3,000 rpm for 10 minutes) and then washed twice in 0.1 M phosphate-buffered saline at pH 7.0. Organisms were resuspended at a concentration of ca. 106 CFU/ml in: a) sterile unused dianeal at 4.25% dextrose, b) sterile unused dianeal at 1.5% dextrose, c) sterile used dialysate previously containing 4.25% dextrose taken from a CAPD patient, and d) sterile used dialysate previously containing 1.5% dextrose taken from a CAPD patient.

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