Preoperative Chemotherapy in Gastric Cancer

1996 ◽  
pp. 237-248 ◽  
Author(s):  
H. Wilke ◽  
H. J. Meyer ◽  
U. Fink
Keyword(s):  
Gastric Cancer ◽  
Preoperative Chemotherapy

What is the most useful body composition parameter for predicting toxicities of preoperative chemotherapy for gastric cancer?

Surgery Today ◽  
2019 ◽  
Vol 50 (5) ◽  
pp. 509-515 ◽  
Author(s):  
Tadayoshi Hashimoto ◽  
Yukinori Kurokawa ◽  
Tsuyoshi Takahashi ◽  
Takuro Saito ◽  
Kotaro Yamashita ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Body Composition ◽  
Preoperative Chemotherapy ◽  
Composition Parameter ◽  
Body Composition Parameter

scholarly journals Neoadjuvant Chemotherapy Compared With Surgery Alone for Locally Advanced Cancer of the Stomach and Cardia: European Organisation for Research and Treatment of Cancer Randomized Trial 40954

2010 ◽  
Vol 28 (35) ◽  
pp. 5210-5218 ◽  
Author(s):  
Christoph Schuhmacher ◽  
Stephan Gretschel ◽  
Florian Lordick ◽  
Peter Reichardt ◽  
Werner Hohenberger ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Neoadjuvant Chemotherapy ◽  
Preoperative Chemotherapy ◽  
Survival Benefit ◽  
Locally Advanced ◽  
Postoperative Chemotherapy ◽  
Phase Iii ◽  
R0 Resection ◽  
Resection Rate

PurposePatients with locally advanced gastric cancer benefit from combined pre- and postoperative chemotherapy, although fewer than 50% could receive postoperative chemotherapy. We examined the value of purely preoperative chemotherapy in a phase III trial with strict preoperative staging and surgical resection guidelines.Patients and MethodsPatients with locally advanced adenocarcinoma of the stomach or esophagogastric junction (AEG II and III) were randomly assigned to preoperative chemotherapy followed by surgery or to surgery alone. To detect with 80% power an improvement in median survival from 17 months with surgery alone to 24 months with neoadjuvant, 282 events were required.ResultsThis trial was stopped for poor accrual after 144 patients were randomly assigned (72:72); 52.8% patients had tumors located in the proximal third of the stomach, including AEG type II and III. The International Union Against Cancer R0 resection rate was 81.9% after neoadjuvant chemotherapy as compared with 66.7% with surgery alone (P = .036). The surgery-only group had more lymph node metastases than the neoadjuvant group (76.5% v 61.4%; P = .018). Postoperative complications were more frequent in the neoadjuvant arm (27.1% v 16.2%; P = .09). After a median follow-up of 4.4 years and 67 deaths, a survival benefit could not be shown (hazard ratio, 0.84; 95% CI, 0.52 to 1.35; P = .466).ConclusionThis trial showed a significantly increased R0 resection rate but failed to demonstrate a survival benefit. Possible explanations are low statistical power, a high rate of proximal gastric cancer including AEG and/or a better outcome than expected after radical surgery alone due to the high quality of surgery with resections of regional lymph nodes outside the perigastic area (celiac trunc, hepatic ligament, lymph node at a. lienalis; D2).

PO-11 Venous thromboembolism in patients receiving preoperative chemotherapy for gastric cancer

2010 ◽  
Vol 125 ◽  
pp. S169
Author(s):  
A.C. Larsen ◽  
K.G. Sunesen ◽  
T. Dabrowski ◽  
R. Vincents Fisker ◽  
M.K. Yilmaz ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Venous Thromboembolism ◽  
Preoperative Chemotherapy

scholarly journals CALGB 80101 and the Final Call for Preoperative Chemotherapy in Gastric Cancer

2018 ◽  
Vol 36 (11) ◽  
pp. 1178-1179 ◽  
Author(s):  
Lorenzo Fornaro ◽  
Mario Scartozzi ◽  
Giuseppe Aprile
Keyword(s):  
Gastric Cancer ◽  
Preoperative Chemotherapy

scholarly journals Venous thromboembolism during preoperative chemotherapy in the CRITICS gastric cancer trial

2018 ◽  
Vol 29 ◽  
pp. viii233
Author(s):  
A.E. Slagter ◽  
K. Sikorska ◽  
C. Grootscholten ◽  
H.W.M. van Laarhoven ◽  
H. Boot ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Venous Thromboembolism ◽  
Preoperative Chemotherapy ◽  
Cancer Trial

Preoperative chemotherapy does not influence the number of evaluable lymph nodes in resected gastric cancer

2012 ◽  
Vol 38 (4) ◽  
pp. 319-325 ◽  
Author(s):  
J.L. Dikken ◽  
N.C.T. van Grieken ◽  
P. Krijnen ◽  
M. Gönen ◽  
L.H. Tang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Nodes ◽  
Preoperative Chemotherapy ◽  
Resected Gastric Cancer

Histopathological response to preoperative chemotherapy including 5-fluorouracil additionally assessed by immunocytochemical and pharmacologic parameters in patients with advanced gastric cancer

Surgery Today ◽  
1996 ◽  
Vol 26 (7) ◽  
pp. 482-488 ◽  
Author(s):  
Hiroshi Nakano ◽  
Kimio Namatame ◽  
Takao Suzuki ◽  
Hiroyoshi Takahashi ◽  
Hitoshi Sakai ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Advanced Gastric Cancer ◽  
Preoperative Chemotherapy ◽  
Histopathological Response
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