Analysis of Auxiliary Bridge Structural Elements with Advanced Design Method

2013 ◽  
pp. 475-484
Author(s):  
Eszter Noficzer ◽  
Miklós Iványi ◽  
M. Miklós Iványi
Keyword(s):  
Design Method ◽  
Structural Elements

scholarly journals Application of Modal-Displacement Based Design Method to Multi-Story Timber Blockhaus Structures

2020 ◽  
Vol 10 (11) ◽  
pp. 3889
Author(s):  
Martina Sciomenta ◽  
Vincenzo Rinaldi ◽  
Chiara Bedon ◽  
Massimo Fragiacomo
Keyword(s):  
Design Method ◽  
Fe Model ◽  
Structural Elements ◽  
Base Shear ◽  
Shear Loads ◽  
Story Drift ◽  
Displacement Based ◽  
Technical Interest ◽  
Wooden Structures

Structures under seismic excitation undergo different inter-story drift levels that can be associated to damage of both structural and non-structural elements, and thus to the expected losses. The Modal-Displacement Based Design (DBD) procedure, in this regard, has been developed to fix major issues of Force Based Design (FBD) approaches, thus to design multi-story buildings in which the inter-story drift can allow one to control damage mechanisms. In this paper, the conventional Modal-DBD methodology is applied to multi-story timber buildings constructed using the Blockhaus technology. Given their intrinsic geometrical and mechanical features (i.e., stacking of logs, door/window openings, gaps and friction mechanisms, etc.), dedicated methods of analysis are required for them, compared to other wooden structures. A three-story case-study Blockhaus system of technical interest is thus presented for the assessment of Modal-DBD calculation steps. As shown, special care must be spent for the selection of convenient inter-story drift limits that in general should reflect the characteristics of the examined structural typology. The backbone parameters are thus collected for each shear-wall composing the 3D Blockhaus building, based on refined Finite Element (FE) analyses of separate log-walls. The overall results of the Modal-DBD process are thus finally assessed by means of a Push-Over (PO) analysis, carried out on a simplified 3D FE model of the examined multi-story structure. The comparison of FE predictions, as shown, demonstrates that reliable estimates can be obtained when the Modal-DBD procedure is applied to timber Blockhaus systems. In particular, base shear loads can be estimated with good accuracy, while the corresponding top displacements are slightly overestimated (with up to +10%–14% the expected values, for the collapse prevention performance level).

scholarly journals Expanding the space of protein geometries by computational design of de novo fold families

2020 ◽  
Author(s):  
Xingjie Pan ◽  
Michael Thompson ◽  
Yang Zhang ◽  
Lin Liu ◽  
James S. Fraser ◽  
...  
Keyword(s):  
De Novo ◽  
Design Method ◽  
Computational Design ◽  
Computational Method ◽  
Structural Elements ◽  
New Paradigm ◽  
Biophysical Characterization ◽  
Structure Space ◽  
Naturally Occurring ◽  
Designer Proteins

AbstractNaturally occurring proteins use a limited set of fold topologies, but vary the precise geometries of structural elements to create distinct shapes optimal for function. Here we present a computational design method termed LUCS that mimics nature’s ability to create families of proteins with the same overall fold but precisely tunable geometries. Through near-exhaustive sampling of loop-helix-loop elements, LUCS generates highly diverse geometries encompassing those found in nature but also surpassing known structure space. Biophysical characterization shows that 17 (38%) out of 45 tested LUCS designs were well folded, including 16 with designed non-native geometries. Four experimentally solved structures closely match the designs. LUCS greatly expands the designable structure space and provides a new paradigm for designing proteins with tunable geometries customizable for novel functions.One Sentence SummaryA computational method to systematically sample loop-helix-loop geometries expands the structure space of designer proteins.

Topological interlocking in architecture: A new design method and computational tool for designing building floors

2017 ◽  
Vol 15 (2) ◽  
pp. 107-118 ◽  
Author(s):  
Michael Weizmann ◽  
Oded Amir ◽  
Yasha Jacob Grobman
Keyword(s):  
Design Process ◽  
Architectural Design ◽  
Design Method ◽  
Structural Systems ◽  
Two Dimensional ◽  
Structural Elements ◽  
Computational Tool ◽  
Topological Interlocking ◽  
Further Development

This article presents a framework for the design process of structural systems based on the notion of topological interlocking. A new design method and a computational tool for generating valid architectural topological interlocking geometries are discussed. In the heart of the method are an algorithm for automatically generating valid two-dimensional patterns and a set of procedures for creating several types of volumetric blocks based on the two-dimensional patterns. Additionally, the computational tool can convert custom sets of closed planar curves into structural elements based on the topological interlocking principle. The method is examined in a case study of a building floor. The article concludes with discussions on the potential advantages of using the method for architectural design, as well as on challenging aspects of further development of this method toward implementation in practice.

103 An Optimum Design Method of Band-Gap Structures Based on Discrete Structural Elements

2006 ◽  
Vol 2006.19 (0) ◽  
pp. 25-26
Author(s):  
Katsuya Mogami ◽  
Shinji Nishiwaki ◽  
Kazuhiro Izui ◽  
Masataka Yoshimura
Keyword(s):  
Band Gap ◽  
Optimum Design ◽  
Design Method ◽  
Structural Elements

scholarly journals Expanding the space of protein geometries by computational design of de novo fold families

Science ◽  
2020 ◽  
Vol 369 (6507) ◽  
pp. 1132-1136
Author(s):  
Xingjie Pan ◽  
Michael C. Thompson ◽  
Yang Zhang ◽  
Lin Liu ◽  
James S. Fraser ◽  
...  
Keyword(s):  
De Novo ◽  
Design Method ◽  
Computational Design ◽  
Structural Elements ◽  
New Paradigm ◽  
Biophysical Characterization ◽  
Structure Space ◽  
Naturally Occurring

Naturally occurring proteins vary the precise geometries of structural elements to create distinct shapes optimal for function. We present a computational design method, loop-helix-loop unit combinatorial sampling (LUCS), that mimics nature’s ability to create families of proteins with the same overall fold but precisely tunable geometries. Through near-exhaustive sampling of loop-helix-loop elements, LUCS generates highly diverse geometries encompassing those found in nature but also surpassing known structure space. Biophysical characterization showed that 17 (38%) of 45 tested LUCS designs encompassing two different structural topologies were well folded, including 16 with designed non-native geometries. Four experimentally solved structures closely matched the designs. LUCS greatly expands the designable structure space and offers a new paradigm for designing proteins with tunable geometries that may be customizable for novel functions.

Structural phenomena in the growth of carbon nanotubes

1993 ◽  
Vol 51 ◽  
pp. 750-751
Author(s):  
Jun Jiao
Keyword(s):  
Carbon Nanotubes ◽  
Growth Mechanism ◽  
Carbonaceous Material ◽  
Cluster Growth ◽  
Structural Elements ◽  
Rich Variety ◽  
Different Shapes ◽  
Point To Point

HREM studies of the carbonaceous material deposited on the cathode of a Huffman-Krätschmer arc reactor have shown a rich variety of multiple-walled nano-clusters of different shapes and forms. The preparation of the samples, as well as the variety of cluster shapes, including triangular, rhombohedral and pentagonal projections, are described elsewhere.The close registry imposed on the nanotubes, focuses attention on the cluster growth mechanism. The strict parallelism in the graphitic separation of the tube walls is maintained through changes of form and size, often leading to 180° turns, and accommodating neighboring clusters and defects. Iijima et. al. have proposed a growth scheme in terms of pentagonal and heptagonal defects and their combinations in a hexagonal graphitic matrix, the first bending the surface inward, and the second outward. We report here HREM observations that support Iijima’s suggestions, and add some new features that refine the interpretation of the growth mechanism. The structural elements of our observations are briefly summarized in the following four micrographs, taken in a Hitachi H-8100 TEM operating at an accelerating voltage of 200 kV and with a point-to-point resolution of 0.20 nm.

Designing TIMP (tissue inhibitor of metalloproteinases) variants that are selective metalloproteinase inhibitors

2003 ◽  
Vol 70 ◽  
pp. 201-212 ◽  
Author(s):  
Hideaki Nagase ◽  
Keith Brew
Keyword(s):  
Three Dimensional ◽  
Therapeutic Interventions ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Structural Basis ◽  
Structural Elements ◽  
Ridge Structure ◽  
Extracellular Matrix Components ◽  
Metalloproteinase Inhibitors ◽  
The Matrix ◽  
A Disintegrin And Metalloproteinase

The tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of the matrix metalloproteinases (MMPs), enzymes that play central roles in the degradation of extracellular matrix components. The balance between MMPs and TIMPs is important in the maintenance of tissues, and its disruption affects tissue homoeostasis. Four related TIMPs (TIMP-1 to TIMP-4) can each form a complex with MMPs in a 1:1 stoichiometry with high affinity, but their inhibitory activities towards different MMPs are not particularly selective. The three-dimensional structures of TIMP-MMP complexes reveal that TIMPs have an extended ridge structure that slots into the active site of MMPs. Mutation of three separate residues in the ridge, at positions 2, 4 and 68 in the amino acid sequence of the N-terminal inhibitory domain of TIMP-1 (N-TIMP-1), separately and in combination has produced N-TIMP-1 variants with higher binding affinity and specificity for individual MMPs. TIMP-3 is unique in that it inhibits not only MMPs, but also several ADAM (a disintegrin and metalloproteinase) and ADAMTS (ADAM with thrombospondin motifs) metalloproteinases. Inhibition of the latter groups of metalloproteinases, as exemplified with ADAMTS-4 (aggrecanase 1), requires additional structural elements in TIMP-3 that have not yet been identified. Knowledge of the structural basis of the inhibitory action of TIMPs will facilitate the design of selective TIMP variants for investigating the biological roles of specific MMPs and for developing therapeutic interventions for MMP-associated diseases.

Application of a work-centered design method to support counterspace operations

2005 ◽  
Author(s):  
Michael Szczepkowski ◽  
Kelly Neville ◽  
Ed Popp
Keyword(s):  
Design Method
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