Tumor Necrosis Factor: Mechanism of Action and its Potential for Anticancer Therapy

1992 ◽  
pp. 119-125
Author(s):  
W. Fiers ◽  
R. Beyaert ◽  
P. Brouckaert ◽  
E. Decoster ◽  
D. De Valck ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Mechanism Of Action ◽  
Tumor Necrosis ◽  
Anticancer Therapy ◽  
Necrosis Factor

Mechanism of action of certolizumab pegol (CDP870): In vitro comparison with other anti-tumor necrosis factor α agents

2007 ◽  
Vol 13 (11) ◽  
pp. 1323-1332 ◽  
Author(s):  
Andrew Nesbitt ◽  
Gianluca Fossati ◽  
Marianne Bergin ◽  
Paul Stephens ◽  
Sue Stephens ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Mechanism Of Action ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Certolizumab Pegol ◽  
Factor Α ◽  
Necrosis Factor ◽  
In Vitro Comparison

Apoptosis as a Mechanism of Action of Tumor Necrosis Factor Antagonists in Rheumatoid Arthritis: Figure 1.

2012 ◽  
Vol 39 (4) ◽  
pp. 679-685 ◽  
Author(s):  
DIMITRIOS MAKRYGIANNAKIS ◽  
ANCA IRINEL CATRINA
Keyword(s):  
Rheumatoid Arthritis ◽  
Tumor Necrosis Factor ◽  
Mechanism Of Action ◽  
Tumor Necrosis ◽  
Unresolved Issue ◽  
Tnf Antagonists ◽  
Tumor Necrosis Factor Antagonists ◽  
Proinflammatory Molecule ◽  
Contradictory Data ◽  
Necrosis Factor

Tumor necrosis factor (TNF) antagonists are drugs developed to block endogenous TNF, an essential proinflammatory molecule with a central role in the pathogenesis of rheumatoid arthritis (RA). Although extensive studies have been performed concerning the mode of action of TNF-blocking agents, there are still many unresolved questions and potential differences between different TNF-blocking drugs. One unresolved issue is to what extent apoptosis is affected by TNF blockade in RA. We provide an overview of studies that have investigated the proapoptotic effect of different anti-TNF drugs in RA, searching for a unified interpretation of somewhat contradictory data.

scholarly journals A human inhibitor of tumor necrosis factor alpha.

1988 ◽  
Vol 167 (4) ◽  
pp. 1511-1516 ◽  
Author(s):  
P Seckinger ◽  
S Isaaz ◽  
J M Dayer
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Mechanism Of Action ◽  
Inhibitory Activity ◽  
Tumor Necrosis ◽  
Tnf Alpha ◽  
Necrosis Factor Alpha ◽  
Competitive Mechanism ◽  
Factor Alpha ◽  
Necrosis Factor

Urine of some febrile patients exhibits a TNF-alpha inhibitory activity (TNF-alpha INH), sensitive to heat and trypsin, with an apparent mol wt of 40-60 X 10(3) and a pI range of 5.5-6.1. As for the Il-1 INH, the TNF INH activity involves a competitive mechanism of action suggesting the existence of a family of negative feedback-regulating molecules interfering with cytokines actions.

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